PCDGL_HUMAN » Protocadherin gamma-C4

PCDGL_HUMAN » Protocadherin gamma-C4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDGL_HUMAN » Protocadherin gamma-C4 » PCDH-gamma-C4;
Hydrophobic Thickness 38.8 ± 0.8 Å
Tilt Angle 2 ± 0°
ΔGtransfer -39.0 kcal/mol
ΔGfold -16.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 685-713 (684-719)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 4ZPN, Subunit A, Seq Identity:54%, Cadherin-like

AA: 138-233, PDBID: 4ZPN, Subunit B, Seq Identity:59%, Cadherin domain

AA: 247-341, PDBID: 4ZPN, Subunit B, Seq Identity:46%, Cadherin domain

AA: 356-446, PDBID: 4ZPL, Subunit A, Seq Identity:37%, Cadherin domain

AA: 460-556, PDBID: 4ZPL, Subunit A, Seq Identity:34%, Cadherin domain

AA: 581-666, PDBID: 3UBH, Subunit A, Seq Identity:30%, Cadherin domain

AA: 816-938, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDGL_HUMAN » Protocadherin gamma-C4
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDGL_HUMAN » Protocadherin gamma-C4
SIGNAL 1 29 Potential.
CHAIN 30 938 Protocadherin gamma-C4.
DOMAIN 30 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 350 Cadherin 3.
DOMAIN 351 455 Cadherin 4.
DOMAIN 456 565 Cadherin 5.
DOMAIN 572 676 Cadherin 6.
Amino Acid Sequence for PCDGL_HUMAN » Protocadherin gamma-C4
MLRKVRSWTE IWRWATLLFL FYHLGYVCGQ IRYPVPEESQ EGTFVGNVAQ DFLLDTDSLS ARRLQVAGEV NQRHFRVDLD SGALLIKNPI DREALCGLSA SCIVPLEFVT EGPLEMYRAE VEIVDVNDHA PRFPRQQLDL EIGEAAPPGQ RFPLEKAQDA DVGSNSISSY RLSSNEHFAL DVKKRSDGSL VPELLLEKPL DREKQSDYRL VLTAVDGGNP PRSGTAELRV SVLDVNDNAP AFQQSSYRIS VLESAPAGMV LIQLNASDPD LGPSGNVTFY FSGHTPDRVR NLFSLHPTTG KLTLLGPLDF ESENYYEFDV RARDGGSPAM EQHCSLRVDL LDVNDNAPYI TVTSELGTLP ESAEPGTVVA LISVQDPDSG SNGDVSLRIP DHLPFALKSA FRNQFSLVTA GPLDREAKSS YDIMVTASDA GNPPLSTHRT IFLNISDVND NPPSFFQRSH EVFVPENNRP GDLLCSLAAS DPDSGLNALI SYSLLEPRNR DVSASSFISL NPQTGAVHAT RSFDYEQTQT LQFEVQARDR GNPPLSSTVT VRLFVLDLND NAPAVLRPRA RPGSLCPQAL PPSVGAGHLI TKVTAVDLDS GYNAWVSYQL LEAPDPSLFA VSRYAGEVRT AVPIPADLPP QKLVIVVKDS GSPPLSTSVT LLVSLEEDTH PVVPDLRESS APREGESRLT LYLAVSLVAI CFVSFGSFVA LLSKCLRGAA CGVTCFPAGT CACLTRSRRR EGLPPSNGIL RIQLGSDDPI KFVDVGGHSH GCTPLASAPT RSDSFMMVKS PSAPMAGEPV RPSCPPSDLL YGLEQAPPNT DWRFSQAQRP GTSGSQNGDD TGTWPNNQFD TEMLQAMILA SASEAADGSS TLGGGAGTMG LSARYGPQFT LQHVPDYRQN VYIPGSNATL TNAAGKRDGK APAGGNGNKK KSGKKEKK