PCDGK_HUMAN » Protocadherin gamma-C3

PCDGK_HUMAN » Protocadherin gamma-C3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDGK_HUMAN » Protocadherin gamma-C3 » PCDH-gamma-C3; Protocadherin-2;Protocadherin-43;PC-43;
Hydrophobic Thickness 35.6 ± 3.6 Å
Tilt Angle 29 ± 0°
ΔGtransfer -33.2 kcal/mol
ΔGfold -22.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 690-718 (684-718)
Pathways none
PDB none
OPM none
Complexes none
Interactions

A4, Complex: A4:PCDGK, PubMed

Domains

AA: 32-114, PDBID: 4ZI8, Subunit B, Seq Identity:90%, Cadherin-like

AA: 140-235, PDBID: 4ZI8, Subunit B, Seq Identity:84%, Cadherin domain

AA: 249-343, PDBID: 4ZI8, Subunit B, Seq Identity:92%, Cadherin domain

AA: 358-448, PDBID: 4ZPL, Subunit A, Seq Identity:40%, Cadherin domain

AA: 462-558, PDBID: 2O72, Subunit A, Seq Identity:28%, Cadherin domain

AA: 580-667, PDBID: 2O72, Subunit A, Seq Identity:29%, Cadherin domain

AA: 689-775, Cadherin cytoplasmic C-terminal

AA: 812-934, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDGK_HUMAN » Protocadherin gamma-C3
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDGK_HUMAN » Protocadherin gamma-C3
SIGNAL 1 31 Potential.
CHAIN 32 934 Protocadherin gamma-C3.
DOMAIN 32 135 Cadherin 1.
DOMAIN 136 244 Cadherin 2.
DOMAIN 245 352 Cadherin 3.
DOMAIN 353 457 Cadherin 4.
DOMAIN 458 567 Cadherin 5.
DOMAIN 572 685 Cadherin 6.
Amino Acid Sequence for PCDGK_HUMAN » Protocadherin gamma-C3
MVPEAWRSGL VSTGRVVGVL LLLGALNKAS TVIHYEIPEE REKGFAVGNV VANLGLDLGS LSARRFRVVS GASRRFFEVN RETGEMFVND RLDREELCGT LPSCTVTLEL VVENPLELFS VEVVIQDIND NNPAFPTQEM KLEISEAVAP GTRFPLESAH DPDVGSNSLQ TYELSRNEYF ALRVQTREDS TKYAELVLER ALDREREPSL QLVLTALDGG TPALSASLPI HIKVLDANDN APVFNQSLYR ARVLEDAPSG TRVVQVLATD LDEGPNGEII YSFGSHNRAG VRQLFALDLV TGMLTIKGRL DFEDTKLHEI YIQAKDKGAN PEGAHCKVLV EVVDVNDNAP EITVTSVYSP VPEDAPLGTV IALLSVTDLD AGENGLVTCE VPPGLPFSLT SSLKNYFTLK TSADLDRETV PEYNLSITAR DAGTPSLSAL TIVRVQVSDI NDNPPQSSQS SYDVYIEENN LPGAPILNLS VWDPDAPQNA RLSFFLLEQG AETGLVGRYF TINRDNGIVS SLVPLDYEDR REFELTAHIS DGGTPVLATN ISVNIFVTDR NDNAPQVLYP RPGGSSVEML PRGTSAGHLV SRVVGWDADA GHNAWLSYSL LGSPNQSLFA IGLHTGQIST ARPVQDTDSP RQTLTVLIKD NGEPSLSTTA TLTVSVTEDS PEARAEFPSG SAPREQKKNL TFYLLLSLIL VSVGFVVTVF GVIIFKVYKW KQSRDLYRAP VSSLYRTPGP SLHADAVRGG LMSPHLYHQV YLTTDSRRSD PLLKKPGAAS PLASRQNTLR SCDPVFYRQV LGAESAPPGQ QAPPNTDWRF SQAQRPGTSG SQNGDDTGTW PNNQFDTEML QAMILASASE AADGSSTLGG GAGTMGLSAR YGPQFTLQHV PDYRQNVYIP GSNATLTNAA GKRDGKAPAG GNGNKKKSGK KEKK