PCDGI_HUMAN » Protocadherin gamma-B6

PCDGI_HUMAN » Protocadherin gamma-B6
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDGI_HUMAN » Protocadherin gamma-B6 » PCDH-gamma-B6;
Hydrophobic Thickness 36.8 ± 6.4 Å
Tilt Angle 38 ± 6°
ΔGtransfer -34.0 kcal/mol
ΔGfold -31.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 684-716 (683-719)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 32-112, PDBID: 4ZI8, Subunit B, Seq Identity:44%, Cadherin-like

AA: 138-233, PDBID: 4ZPS, Subunit A, Seq Identity:42%, Cadherin domain

AA: 247-338, PDBID: 4ZI9, Subunit B, Seq Identity:43%, Cadherin domain

AA: 353-443, PDBID: 4ZPL, Subunit A, Seq Identity:38%, Cadherin domain

AA: 457-553, PDBID: 4ZI8, Subunit B, Seq Identity:34%, Cadherin domain

AA: 577-663, PDBID: 2EE0, Subunit A, Seq Identity:30%, Cadherin domain

AA: 687-768, Cadherin cytoplasmic C-terminal

AA: 808-930, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDGI_HUMAN » Protocadherin gamma-B6
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDGI_HUMAN » Protocadherin gamma-B6
SIGNAL 1 30 Potential.
CHAIN 31 930 Protocadherin gamma-B6.
DOMAIN 31 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 347 Cadherin 3.
DOMAIN 348 452 Cadherin 4.
DOMAIN 453 562 Cadherin 5.
DOMAIN 570 675 Cadherin 6.
Amino Acid Sequence for PCDGI_HUMAN » Protocadherin gamma-B6
MGGSCAQRRR AGPRQVLFPL LLPLFYPTLS EPIRYSIPEE LAKGSVVGNL AKDLGLSVLD VSARKLRVSA EKLHFSVDAE SGDLLVKNRI DREQICKERR RCELQLEAVV ENPLNIFHVI VVIEDVNDHA PQFDKKEIHL EIFESASAGT RLSLDPATDP DININSIKDY KINSNPYFSL MVRVNSDGGK YPELSLEKLL DREEQRSHSL ILTALDGGDP PRSATAHIEI SVKDTNDNPP VFSRDEYRIS LSENLPPGSP VLQVTATDQD EGVNAEINYY FRSTAQSTKH MFSLDEKTGM IKNNQSFDFE DVERYTMEVE AKDGGGLSTQ CKVIIEILDE NDNSPEIIIT SLSDQILENS PPGMVVALFK TRDLDFGGNG EVRCNIETDI PFKIYSSSNN YYKLVTDGAL DREQTPEYNV TIVATDRGKP PLSSSRSITL YVADINDNAP VFDQTSYVVH VAENNPPGAS IAQVSASDPD LGLNGHISYS IVASDLEPLA VSSYVSVSAQ SGVVFAQRAF DHEQLRAFAL TLQARDHGSP TLSANVSLRV LVGDRNDNAP RVLYPALGPD GSAFFDMVPR SAEPGYLVTK VVAVDADSGH NAWLSYHVLQ ASEPGLFSLG LRTGEVRTAR ALGDRDAARQ RLLVAVRDGG QPPLSATATL HLVFADNLQE ILPDLSDRPV LSDPQAELQF YLVVALALIS VLFLLAVILA IALRLRRSLS PATWDCFHPG LCVKSGPVVP PNYSEGTLPY SYNLCIAHTG TKEFNFLKCS VPLHSNEDMV CSVSPGALIP PHGGEDLTSH PETLTSQAPP NTDWRFSQAQ RPGTSGSQNG DDTGTWPNNQ FDTEMLQAMI LASASEAADG SSTLGGGAGT MGLSARYGPQ FTLQHVPDYR QNVYIPGSNA TLTNAAGKRD GKAPAGGNGN KKKSGKKEKK