PCDGH_HUMAN » Protocadherin gamma-B5

PCDGH_HUMAN » Protocadherin gamma-B5
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDGH_HUMAN » Protocadherin gamma-B5 » PCDH-gamma-B5;
Hydrophobic Thickness 37.2 ± 4.4 Å
Tilt Angle 24 ± 10°
ΔGtransfer -33.7 kcal/mol
ΔGfold -31.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 684-712 (681-715)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 32-112, PDBID: 4ZI8, Subunit B, Seq Identity:47%, Cadherin-like

AA: 138-233, PDBID: 4ZI8, Subunit B, Seq Identity:49%, Cadherin domain

AA: 247-334, PDBID: 4ZI9, Subunit B, Seq Identity:45%, Cadherin domain

AA: 351-439, PDBID: 4ZPL, Subunit A, Seq Identity:36%, Cadherin domain

AA: 453-549, PDBID: 4ZI8, Subunit B, Seq Identity:34%, Cadherin domain

AA: 573-659, PDBID: 3UBH, Subunit A, Seq Identity:30%, Cadherin domain

AA: 683-764, Cadherin cytoplasmic C-terminal

AA: 801-923, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDGH_HUMAN » Protocadherin gamma-B5
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDGH_HUMAN » Protocadherin gamma-B5
SIGNAL 1 30 Potential.
CHAIN 31 923 Protocadherin gamma-B5.
DOMAIN 31 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 343 Cadherin 3.
DOMAIN 344 448 Cadherin 4.
DOMAIN 449 558 Cadherin 5.
DOMAIN 566 671 Cadherin 6.
Amino Acid Sequence for PCDGH_HUMAN » Protocadherin gamma-B5
MGSGAGELGR AERLPVLFLF LLSLFCPALC EQIRYRIPEE MPKGSVVGNL ATDLGFSVQE LPTRKLRVSS EKPYFTVSAE SGELLVSSRL DREEICGKKP ACALEFEAVA ENPLNFYHVN VEIEDINDHT PKFTQNSFEL QISESAQPGT RFILEVAEDA DIGLNSLQKY KLSLNPSFSL IIKEKQDGSK YPELALEKTL DREQQSYHRL VLTALDGGHP PLSGTTELRI QVTDANDNPP VFNRDVYRVS LRENVPPGTT VLQVSATDQD EGINSEITYS FYRTGQIFSL NSKSGEITTQ KKLDFEETKE YSMVVEGRDG GGLVAQCTVE INIQDENDNS PEVTFHSLLE MILENAVPGT LIALIKIHDQ DSGENGEVNC QLQGEVPFKI ISSSKNSYKL VTDGTLDREQ TPEYNVTITA TDRGKPPLSS SISVILHIRD VNDNAPVFHQ ASYLVSVPEN NPPGASIAQV CASDLDLGLN GQVSYSIMAS DLEPLALASY VSMSAQSGVV FAQRAFDYEQ LRTFELTLQA RDQGSPALSA NVSLRVLVGD RNDNAPRVLY PALGPDGSAL FDMVPRAAEP GYLVTKVVAV DADSGHNAWL SYHVLQASEP GLFSLGLRTG EVRTARALGD RDAARQRLLV AVRDGGQPPL SATATLHLVF ADSLQEVLPD ITDRPVPSDP QAELQFYLVV ALALISVLFL LAVILAVALR LRRSSSPAAW SCFQPGLCVK SGPVVPPNYS QGTLPYSYNL CVAHTGKTEF NFLKCSEQLS SGQDILCGDS SGALFPLCNS SESTSHPELQ APPNTDWRFS QAQRPGTSGS QNGDDTGTWP NNQFDTEMLQ AMILASASEA ADGSSTLGGG AGTMGLSARY GPQFTLQHVP DYRQNVYIPG SNATLTNAAG KRDGKAPAGG NGNKKKSGKK EKK