PCDGG_HUMAN » Protocadherin gamma-B4

PCDGG_HUMAN » Protocadherin gamma-B4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDGG_HUMAN » Protocadherin gamma-B4 » PCDH-gamma-B4; Cadherin-20;Fibroblast cadherin-2;
Hydrophobic Thickness 35.2 ± 5.6 Å
Tilt Angle 44 ± 11°
ΔGtransfer -33.7 kcal/mol
ΔGfold -31.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 681-710 (681-717)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 32-112, PDBID: 4ZI8, Subunit B, Seq Identity:47%, Cadherin-like

AA: 138-233, PDBID: 4ZPN, Subunit B, Seq Identity:51%, Cadherin domain

AA: 247-336, PDBID: 2EE0, Subunit A, Seq Identity:40%, Cadherin domain

AA: 353-441, PDBID: 4ZPL, Subunit A, Seq Identity:33%, Cadherin domain

AA: 455-551, PDBID: 2WCP, Subunit A, Seq Identity:33%, Cadherin domain

AA: 575-661, PDBID: 3UBH, Subunit A, Seq Identity:30%, Cadherin domain

AA: 685-766, Cadherin cytoplasmic C-terminal

AA: 801-923, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDGG_HUMAN » Protocadherin gamma-B4
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDGG_HUMAN » Protocadherin gamma-B4
SIGNAL 1 30 Potential.
CHAIN 31 923 Protocadherin gamma-B4.
DOMAIN 31 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 345 Cadherin 3.
DOMAIN 346 450 Cadherin 4.
DOMAIN 451 560 Cadherin 5.
DOMAIN 568 673 Cadherin 6.
Amino Acid Sequence for PCDGG_HUMAN » Protocadherin gamma-B4
MGSGAGELGR AERLPVLFLF LLSLFCPALC EQIRYRIPEE MPKGSVVGNL ATDLGFSVQE LPTRKLRVSS EKPYFTVSAE SGELLVSSRL DREEICGKKP ACALEFEAVA ENPLNFYHVN VEIEDINDHT PKFTQNSFEL QISESAQPGT RFILGSAHDA DIGSNTLQNY QLSPSDHFSL INKEKSDGSK YPEMVLKTPL DREKQKSYHL TLTALDFGAP PLSSTAQIHV LVTDANDNAP VFSQDVYRVS LSENVYPGTT VLQVTATDQD EGVNAEITFS FSEASQITQF DLNSNTGEIT VLNTLDFEEV KEYSIVLEAR DGGGMIAQCT VEVEVIDEND NAPEVIFQSL PNLIMEDAEL GTHIALLKVR DKDSRHNGEV TCKLEGDVPF KILTSSRNTY KLVTDAVLDR EQNPEYNITV TATDRGKPPL SSSSSITLHI GDVNDNAPVF SQSSYIVHVA ENNPPGASIS QVRASDPDLG PNGQVSYCIM ASDLEQRELS SYVSISAESG VVFAQRAFDH EQLRAFELTL QARDQGSPAL SANVSLRVLV DDRNDNAPRV LYPALGPDGS ALFDMVPHAA EPGYLVTKVV AVDADSGHNA WLSYHVLQAS EPGLFSLGLR TGEVRTARAL GDRDAVRQRL LVAVRDGGQP PLSATATLHL VFADSLQEVL PDITDRPDPS DLQAELQFYL VVALALISVL FLVAMILAIA LRLRRSSSPA SWSCFQPGLC VKSESVVPPN YSEGTLPYSY NLCVAHTGKT EFNFLKCSEQ LSSGQDILCG DSSGALFPLC NSSELTSHQQ APPNTDWRFS QAQRPGTSGS QNGDDTGTWP NNQFDTEMLQ AMILASASEA ADGSSTLGGG AGTMGLSARY GPQFTLQHVP DYRQNVYIPG SNATLTNAAG KRDGKAPAGG NGNKKKSGKK EKK