PCDGF_HUMAN » Protocadherin gamma-B3

PCDGF_HUMAN » Protocadherin gamma-B3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDGF_HUMAN » Protocadherin gamma-B3 » PCDH-gamma-B3;
Hydrophobic Thickness 39.6 ± 4.4 Å
Tilt Angle 13 ± 10°
ΔGtransfer -34.6 kcal/mol
ΔGfold -30.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 688-715 (685-720)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 32-112, PDBID: 4ZI8, Subunit B, Seq Identity:45%, Cadherin-like

AA: 138-233, PDBID: 4ZPS, Subunit A, Seq Identity:57%, Cadherin domain

AA: 247-338, PDBID: 4ZI8, Subunit B, Seq Identity:41%, Cadherin domain

AA: 352-443, PDBID: 4ZPL, Subunit A, Seq Identity:41%, Cadherin domain

AA: 457-553, PDBID: 2WCP, Subunit A, Seq Identity:32%, Cadherin domain

AA: 577-663, PDBID: 2EE0, Subunit A, Seq Identity:32%, Cadherin domain

AA: 687-769, Cadherin cytoplasmic C-terminal

AA: 807-929, Cadherin C-terminal cytoplasmic tail, catenin-binding region
UniProt annotation for PCDGF_HUMAN » Protocadherin gamma-B3
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDGF_HUMAN » Protocadherin gamma-B3
SIGNAL 1 30 Potential.
CHAIN 31 929 Protocadherin gamma-B3.
DOMAIN 31 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 347 Cadherin 3.
DOMAIN 348 452 Cadherin 4.
DOMAIN 453 562 Cadherin 5.
DOMAIN 570 675 Cadherin 6.
Amino Acid Sequence for PCDGF_HUMAN » Protocadherin gamma-B3
MGNSSGWRGP AGQRRMLFLF LLSLLDQVLS EPIRYAIPEE LDRGSLVGNL AKDLGFGVGD LPTRNLRVIA EKKFFTVSPE NGNLLVSDRI DREEICGKKS TCVLEFEMVA EKPLNFFHVT VLIQDINDNP PTFSQNITEL EISELALTGA TFALESAQDP DVGVNSLQQY YLSPDPHFSL IQKENLDGSR YPELVLKAPL DREEQPHHHL VLTAVDGGEP SRSCTTQIRV IVADANDNPP VFTQDMYRVN VAENLPAGSS VLKVMAIDMD EGINAEIIYA FINIGKEVRQ LFKLDSKTGE LTTIGELDFE ERDSYTIGVE AKDGGHHTAY CKVQIDISDE NDNAPEITLA SESQHIQEDA ELGTAVALIK THDLDSGFNG EILCQLKGNF PFKIVQDTKN TYRLVTDGAL DREQIPEYNV TITATDKGNP PLSSSKTITL HILDVNDNVP VFHQASYTVH VAENNPPGAS IAHVRASDPD LGPNGLVSYY IVASDLEPRE LSSYVSVSAR SGVVFAQRAF DHEQLRAFEL TLQARDQGSP TLSANVSLRV LVDDRNDNAP LVLYPALGPE GSALFDMVPR SAEPGYLVTK VVAVDADSGY NAWLSYHIVQ ASEPGLFSLG LRTGEVRTAR TLGDREAARQ RLLVTVRDGG QQPLSATVML HLIFADSLQE IQPDLSDRPT PSDPQAELQF HLVVALALIS VLFLLAVILA ISLRLRCSSR PATEGYFQPG VCFKTVPGVL PTYSERTLPY SYNPCAASHS SNTEFKFLNI KAENAAPQDL LCDEASWFES NDNPEMPSNS GNLQKQAPPN TDWRFSQAQR PGTSGSQNGD DTGTWPNNQF DTEMLQAMIL ASASEAADGS STLGGGAGTM GLSARYGPQF TLQHVPDYRQ NVYIPGSNAT LTNAAGKRDG KAPAGGNGNK KKSGKKEKK