PCDGE_HUMAN » Protocadherin gamma-B2

PCDGE_HUMAN » Protocadherin gamma-B2
Magnify PCDGE_HUMAN » Protocadherin gamma-B2Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDGE_HUMAN » Protocadherin gamma-B2 » PCDH-gamma-B2;
Hydrophobic Thickness 34.4 ± 5.2 Å
Tilt Angle 31 ± 6°
ΔGtransfer -32.2 kcal/mol
ΔGfold -30.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 689-714 (684-720)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 32-112, PDBID: 4ZI9, Subunit A, Seq Identity:44%, Cadherin-like

AA: 138-233, PDBID: 4ZPL, Subunit A, Seq Identity:52%, Cadherin domain

AA: 247-338, PDBID: 4ZI8, Subunit B, Seq Identity:43%, Cadherin domain

AA: 352-443, PDBID: 4ZPL, Subunit A, Seq Identity:40%, Cadherin domain

AA: 457-553, PDBID: 2WCP, Subunit A, Seq Identity:32%, Cadherin domain

AA: 577-663, PDBID: 3UBH, Subunit A, Seq Identity:30%, Cadherin domain

AA: 687-769, Cadherin cytoplasmic C-terminal

AA: 809-931, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDGE_HUMAN » Protocadherin gamma-B2
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDGE_HUMAN » Protocadherin gamma-B2
SIGNAL 1 30 Potential.
CHAIN 31 931 Protocadherin gamma-B2.
DOMAIN 31 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 347 Cadherin 3.
DOMAIN 348 452 Cadherin 4.
DOMAIN 453 562 Cadherin 5.
DOMAIN 570 675 Cadherin 6.
Amino Acid Sequence for PCDGE_HUMAN » Protocadherin gamma-B2
MKASSGRCGL VRWLQVLLPF LLSLFPGALP VQIRYSIPEE LAKNSVVGNL AKDLGLSVRD LPARKLRVSA EKEYFTVNPE SGDLLVSDRI DREQICGKQP LCVLDFDTVA ENPLNIFYIA VIVQDINDNT PLFKQTKINL KIGESTKPGT TFPLDPALDS DVGPNSLQRY HLNDNEYFDL AEKQTPDGRK YPELILKHSL DREEHSLHQL VLTAVDGGDP PQSGTTQIRI KVTDANDNPP VFSQDVYRVT LREDVPPGFF VLQVTATDRD EGINAEITYS FHNVDEQVKH FFNLNEKTGE ITTKDDLDFE IASSYTLSIE AKDPGDLAAH CSIQVEILDD NDCAPEVIVT SVSTPLPEDS PPGTVIALIK TRDRDSGENG EVYCQVLGNA KFILKSSSKN YYKLVTDGAL DREEIPEYNL TITATDGGKP PLSSSIIVTL HISDVNDNAP VFQQTSYMVH VAENNPPGAS IAQISASDPD LGPSGQVSYS IVASDLKPRE ILSYVSVSAQ SGVVFAQRAF DHEQLRAFEL TLQARDQGSP ALSANVSLRV LVGDLNDNAP RVLYPALGPD GSALFDMVPR AAEPGYLVTK VVAVDADSGH NAWLSYHVLQ ASEPGLFSLG LRTGEVRTAR ALGDRDAARQ RLLVAVRDGG QPPLSATATL HLIFADSLQE VLPDLSDRRE PSDPQAKLQF YLVVALALIS VLFFLAVILA ISLRLRLSSR SDAWDCFQPG LSSKPGPGVL PNYSEGTLPY SYNLCVASQS AKTEFNFLNI TPELVPAQDL VCDNASWEQN TNHGAAGVPF ASDTILKQAP PNTDWRFSQA QRPGTSGSQN GDDTGTWPNN QFDTEMLQAM ILASASEAAD GSSTLGGGAG TMGLSARYGP QFTLQHVPDY RQNVYIPGSN ATLTNAAGKR DGKAPAGGNG NKKKSGKKEK K