PCDGC_HUMAN » Protocadherin gamma-A12

PCDGC_HUMAN » Protocadherin gamma-A12
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDGC_HUMAN » Protocadherin gamma-A12 » PCDH-gamma-A12; Cadherin-21;Fibroblast cadherin-3;
Hydrophobic Thickness 40.4 ± 4.4 Å
Tilt Angle 19 ± 7°
ΔGtransfer -32.6 kcal/mol
ΔGfold -28.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 689-717 (684-717)
Pathways none
PDB none
OPM none
Complexes none
Interactions

A4, Complex: PCDGC:A4, PubMed

Domains

AA: 30-112, PDBID: 4ZPS, Subunit A, Seq Identity:72%, Cadherin-like

AA: 138-233, PDBID: 4ZPS, Subunit A, Seq Identity:65%, Cadherin domain

AA: 247-338, PDBID: 4ZI9, Subunit B, Seq Identity:57%, Cadherin domain

AA: 353-443, PDBID: 4ZPL, Subunit A, Seq Identity:37%, Cadherin domain

AA: 457-553, PDBID: 4ZPL, Subunit A, Seq Identity:35%, Cadherin domain

AA: 578-665, PDBID: 4ZPM, Subunit A, Seq Identity:31%, Cadherin domain

AA: 688-772, Cadherin cytoplasmic C-terminal

AA: 810-932, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDGC_HUMAN » Protocadherin gamma-A12
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDGC_HUMAN » Protocadherin gamma-A12
SIGNAL 1 29 Potential.
CHAIN 30 932 Protocadherin gamma-A12.
DOMAIN 30 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 347 Cadherin 3.
DOMAIN 348 452 Cadherin 4.
DOMAIN 453 562 Cadherin 5.
DOMAIN 570 683 Cadherin 6.
Amino Acid Sequence for PCDGC_HUMAN » Protocadherin gamma-A12
MIPARLHRDY KGLVLLGILL GTLWETGCTQ IRYSVPEELE KGSRVGDISR DLGLEPRELA ERGVRIIPRG RTQLFALNPR SGSLVTAGRI DREELCMGAI KCQLNLDILM EDKVKIYGVE VEVRDINDNA PYFRESELEI KISENAATEM RFPLPHAWDP DIGKNSLQSY ELSPNTHFSL IVQNGADGSK YPELVLKRAL DREEKAAHHL VLTASDGGDP VRTGTARIRV MVLDANDNAP AFAQPEYRAS VPENLALGTQ LLVVNATDPD EGVNAEVRYS FRYVDDKAAQ VFKLDCNSGT ISTIGELDHE ESGFYQMEVQ AMDNAGYSAR AKVLITVLDV NDNAPEVVLT SLASSVPENS PRGTLIALLN VNDQDSEENG QVICFIQGNL PFKLEKSYGN YYSLVTDIVL DREQVPSYNI TVTATDRGTP PLSTETHISL NVADTNDNPP VFPQASYSAY IPENNPRGVS LVSVTAHDPD CEENAQITYS LAENTIQGAS LSSYVSINSD TGVLYALSSF DYEQFRDLQV KVMARDNGHP PLSSNVSLSL FVLDQNDNAP EILYPALPTD GSTGVELAPR SAEPGYLVTK VVAVDRDSGQ NAWLSYRLLK ASEPGLFSVG LHTGEVRTAR ALLDRDALKQ SLVVAVQDHG QPPLSATVTL TVAVADSIPQ VLADLGSLES PANSETSDLT LYLVVAVAAV SCVFLAFVIL LLALRLRRWH KSRLLQASGG GLTGAPASHF VGVDGVQAFL QTYSHEVSLT TDSRKSHLIF PQPNYADMLV SQESFEKSEP LLLSGDSVFS KDSHGLIEQA PPNTDWRFSQ AQRPGTSGSQ NGDDTGTWPN NQFDTEMLQA MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK