PCDGB_HUMAN » Protocadherin gamma-A11

PCDGB_HUMAN » Protocadherin gamma-A11
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDGB_HUMAN » Protocadherin gamma-A11 » PCDH-gamma-A11;
Hydrophobic Thickness 38.4 ± 2.6 Å
Tilt Angle 4 ± 0°
ΔGtransfer -53.7 kcal/mol
ΔGfold -29.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 693-718 (688-724)
Pathways none
PDB none
OPM none
Complexes none
Interactions

RYK, Complex: PCDGB:RYK, PubMed

Domains

AA: 31-113, PDBID: 4ZPS, Subunit A, Seq Identity:74%, Cadherin-like

AA: 248-339, PDBID: 4ZI9, Subunit B, Seq Identity:56%, Cadherin domain

AA: 355-444, PDBID: 4ZPL, Subunit A, Seq Identity:35%, Cadherin domain

AA: 458-554, PDBID: 2WCP, Subunit A, Seq Identity:35%, Cadherin domain

AA: 579-666, PDBID: 2EE0, Subunit A, Seq Identity:30%, Cadherin domain

AA: 689-773, Cadherin cytoplasmic C-terminal

AA: 813-935, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDGB_HUMAN » Protocadherin gamma-A11
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDGB_HUMAN » Protocadherin gamma-A11
SIGNAL 1 29 Potential.
CHAIN 30 935 Protocadherin gamma-A11.
DOMAIN 30 134 Cadherin 1.
DOMAIN 135 243 Cadherin 2.
DOMAIN 244 348 Cadherin 3.
DOMAIN 349 453 Cadherin 4.
DOMAIN 454 563 Cadherin 5.
DOMAIN 571 677 Cadherin 6.
Amino Acid Sequence for PCDGB_HUMAN » Protocadherin gamma-A11
MANRLQRGDR SRLLLLLCIF LGTLRGFRAR QIRYSVPEET EKGSFVGNIS KDLGLEPREL AKRGVRIVSR GKTQLFAVNP RSGSLITAGR IDREELCETV SSCFLNMELL VEDTLKIYGV EVEIIDINDN APSFQEDEVE IKVSEHAIPG ARFALPNARD PDVGVNSLQS YQLSPNNYFS LQLRGRTDGA KNPELVLEGS LDREKEAAHL LLLTALDGGD PIRKGAVPIR VVVLDVNDHI PMFTQSVYRV SVPENISSGT RVLMVNATDP DEGINGEVMY SFRNMESKAS EIFQLDSQTG EVQVRGSLDF EKYRFYEMEI QGQDGGGLFT TTTMLITVVD VNDNAPEITI TSSINSILEN SPPGTVIALL NVQDQDSGEN GQVSCFIPNH LPFKLEKTYG NYYKLITSRV LDRELVQSYN ITLTATDQGS PPLSAETHVW LNVADDNDNP PVFPHSSYSA YIPENNPRGA SIFSVTALDP DSKQNALVTY SLTDDTVQGV PLSSYVSINS NTGVLYALQS FDYEQFRDLE LRVIARDSGD PPLSSNVSLS LFVLDQNDNA PEILYPALPT DGSTGVELAP RSAEPGYLVT KVVAVDKDSG QNAWLSYRLL KASEPGLFAV GEHTGEVRTA RALLDRDALK QSLVVAVQDH GQPPLSATVT LTVAVADSIP EVLADLGSLE SLANSETSDL SLYLVVAVAA VSCIFLVFVI VLLALRLWRW HKSRLLQASE GGLAGMPTSH FVGVDGVQAF LQTYSHEVSL IADSQKSHLI FPQPNYGDTL ISQESCEKSE PLLIAEDSAI ILGKCDPTSN QQAPPNTDWR FSQAQRPGTS GSQNGDDTGT WPNNQFDTEM LQAMILASAS EAADGSSTLG GGAGTMGLSA RYGPQFTLQH VPDYRQNVYI PGSNATLTNA AGKRDGKAPA GGNGNKKKSG KKEKK