PCDG8_HUMAN » Protocadherin gamma-A8

PCDG8_HUMAN » Protocadherin gamma-A8
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDG8_HUMAN » Protocadherin gamma-A8 » PCDH-gamma-A8;
Hydrophobic Thickness 37.2 ± 2.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -48.5 kcal/mol
ΔGfold -25.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 689-714 (686-717)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 4ZPS, Subunit A, Seq Identity:81%, Cadherin-like

AA: 138-233, PDBID: 4ZPS, Subunit A, Seq Identity:84%, Cadherin domain

AA: 247-338, PDBID: 4ZPS, Subunit A, Seq Identity:69%, Cadherin domain

AA: 354-443, PDBID: 3UBH, Subunit A, Seq Identity:33%, Cadherin domain

AA: 457-553, PDBID: 2WCP, Subunit A, Seq Identity:33%, Cadherin domain

AA: 578-665, PDBID: 4ZPL, Subunit A, Seq Identity:30%, Cadherin domain

AA: 688-772, Cadherin cytoplasmic C-terminal

AA: 810-932, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDG8_HUMAN » Protocadherin gamma-A8
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDG8_HUMAN » Protocadherin gamma-A8
SIGNAL 1 29 Potential.
CHAIN 30 932 Protocadherin gamma-A8.
DOMAIN 30 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 347 Cadherin 3.
DOMAIN 348 452 Cadherin 4.
DOMAIN 453 562 Cadherin 5.
DOMAIN 570 682 Cadherin 6.
Amino Acid Sequence for PCDG8_HUMAN » Protocadherin gamma-A8
MAAPQSRPRR GELILLCALL GTLWEIGRGQ IRYSVPEETD KGSFVGNISK DLGLDPRKLA KHGVRIVSRG RTQLFALNPR SGSLITAGRI DREELCAQSP RCLININTLV EDKGKLFGVE IEIIDINDNN PKFQVEDLEV KINEIAVPGA RYPLPEAVDP DVGVNSLQSY QLSPNHHFSL DVQTGDNGAI NPELVLERAL DREEEAAHHL VLTASDGGKP PRSSTVRIHV TVLDTNDNAP VFPHPIYRVK VLENMPPGTR LLTVTASDPD EGINGKVAYK FRKINEKQTP LFQLNENTGE ISIAKSLDYE ECSFYEMEIQ AEDVGALLGR TKLLISVEDV NDNRPEVIIT SLFSPVLENS LPGTVIAFLS VHDQDSGKNG QVVCYTRDNL PFKLEKSIGN YYRLVTRKYL DRENVSIYNI TVMASDLGTP PLSTETQIAL HVADINDNPP TFPHASYSAY ILENNLRGAS IFSLTAHDPD SQENAQVTYS VTEDTLQGAP LSSYISINSD TGVLYALQSF DYEQIRDLQL LVTASDSGDP PLSSNMSLSL FVLDQNDNAP EILYPALPTD GSTGVELAPR SAERGYLVTK VVAVDRDSGQ NAWLSYRLLK ASEPGLFSVG LHTGEVRTAR ALLDRDALKQ SLVVAVQDHG QPPLSATVTL TVAVADSIPE VLTELGSLKP SVDPNDSSLT LYLVVAVAAI SCVFLAFVAV LLGLRLRRWH KSRLLQDSGG RLVGVPASHF VGVEEVQAFL QTYSQEVSLT ADSRKSHLIF PQPNYADMLI SQEGCEKNDS LLTSVDFHEY KNEADHGQQA PPNTDWRFSQ AQRPGTSGSQ NGDDTGTWPN NQFDTEMLQA MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK