PCDG7_HUMAN » Protocadherin gamma-A7

PCDG7_HUMAN » Protocadherin gamma-A7
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDG7_HUMAN » Protocadherin gamma-A7 » PCDH-gamma-A7;
Hydrophobic Thickness 40.8 ± 2.2 Å
Tilt Angle 1 ± 1°
ΔGtransfer -50.8 kcal/mol
ΔGfold -27.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 689-716 (687-717)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 4ZI9, Subunit A, Seq Identity:81%, Cadherin-like

AA: 138-233, PDBID: 4ZPS, Subunit A, Seq Identity:75%, Cadherin domain

AA: 247-338, PDBID: 4ZI9, Subunit B, Seq Identity:59%, Cadherin domain

AA: 352-443, PDBID: 4ZPL, Subunit A, Seq Identity:40%, Cadherin domain

AA: 457-553, PDBID: 2WCP, Subunit A, Seq Identity:34%, Cadherin domain

AA: 578-665, PDBID: 3UBH, Subunit A, Seq Identity:31%, Cadherin domain

AA: 688-772, Cadherin cytoplasmic C-terminal

AA: 810-932, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDG7_HUMAN » Protocadherin gamma-A7
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDG7_HUMAN » Protocadherin gamma-A7
SIGNAL 1 28 Potential.
CHAIN 29 932 Protocadherin gamma-A7.
DOMAIN 29 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 347 Cadherin 3.
DOMAIN 348 452 Cadherin 4.
DOMAIN 453 562 Cadherin 5.
DOMAIN 570 682 Cadherin 6.
Amino Acid Sequence for PCDG7_HUMAN » Protocadherin gamma-A7
MAAQPRGGDY RGFFLLSILL GTPWEAWAGR ILYSVSEETD KGSFVGDIAK DLGLEPRELA ERGVRIISRG RTQLFALNQR SGSLVTAGRI DREEICAQSA RCLVNFNILM EDKMNLYPID VEIIDINDNV PRFLTEEINV KIMENTAPGV RFPLSEAGDP DVGTNSLQSY QLSPNRHFSL AVQSGDDETK YPELVLERVL DREEERVHHL VLTASDGGDP PRSSTAHIQV TVVDVNDHTP VFSLPQYQVT VPENVPVGTR LLTVHAIDLD EGVNGEVTYS FRKITPKLPK MFHLNSLTGE ISTLEGLDYE ETAFYEMEVQ AQDGPGSLTK AKVLITVLDV NDNAPEVTMT SLSSSIPEDT PLGTVIALFY LQDRDSGKNG EVTCTIPENL PFKLEKSIDN YYRLVTTKNL DRETLSLYNI TLKATDGGTP PLSRETHIFM QVADTNDNPP TFPHSSYSVY IAENNPRGAS IFLVTAQDHD SEDNAQITYS LAEDTIQGAP VSSYVSINSD TGVLYALQSF DYEQLRELQL RVTAHDSGDP PLSSNMSLSL FVLDQNDNPP EILYPALPTD GSTGMELAPR SAEPGYLVTK VVAVDKDSGQ NAWLSYLLLK ASEPGLFAVG LYTGEVRTAR ALLDRDALKQ SLVVAVQDHG QPPLSATVTL TVAVADSIPE VLADLGSLEP SDGPYNYDLT LYLVVAVATV SCVFLAFVLV LLALRLRRWH KSRLLQASEG GLANVPTSHF VGMDGVQAFL QTYSHEVSLT ADSRKSHLIF PQPNYVDMLI SQESCEKNDS LLTSVDFQEC KENLPSIQQA PPNTDWRFSQ AQRPGTSGSQ NGDDTGTWPN NQFDTEMLQA MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK