PCDG6_HUMAN » Protocadherin gamma-A6

PCDG6_HUMAN » Protocadherin gamma-A6
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDG6_HUMAN » Protocadherin gamma-A6 » PCDH-gamma-A6;
Hydrophobic Thickness 35.6 ± 1.4 Å
Tilt Angle 1 ± 1°
ΔGtransfer -46.9 kcal/mol
ΔGfold -27.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 689-716 (686-717)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 4ZPS, Subunit A, Seq Identity:81%, Cadherin-like

AA: 138-233, PDBID: 4ZPS, Subunit A, Seq Identity:64%, Cadherin domain

AA: 247-338, PDBID: 4ZI9, Subunit B, Seq Identity:52%, Cadherin domain

AA: 353-443, PDBID: 4ZPL, Subunit A, Seq Identity:38%, Cadherin domain

AA: 457-553, PDBID: 2WCP, Subunit A, Seq Identity:36%, Cadherin domain

AA: 578-665, PDBID: 4ZPM, Subunit A, Seq Identity:31%, Cadherin domain

AA: 688-772, Cadherin cytoplasmic C-terminal

AA: 810-932, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDG6_HUMAN » Protocadherin gamma-A6
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDG6_HUMAN » Protocadherin gamma-A6
SIGNAL 1 29 Potential.
CHAIN 30 932 Protocadherin gamma-A6.
DOMAIN 30 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 347 Cadherin 3.
DOMAIN 348 452 Cadherin 4.
DOMAIN 453 562 Cadherin 5.
DOMAIN 570 682 Cadherin 6.
Amino Acid Sequence for PCDG6_HUMAN » Protocadherin gamma-A6
MAPPQRHPQR SEQVLLLTLL GTLWGAAAAQ IRYSIPEELE KGSFVGNIVK DLGLEPQELA EHGVRIVSRG RMQLFSLNPR NGSLVTAGRI DREELCAQSP RCLVSFNILV EDKLNLYPVE VEIVDINDNT PRFLKEELEV KILENAAPSS RFPLMEVYDP DVGMNSLQGF KLSGNSHFSV DVQSEAHGPK YPELVLEGTL DREGEAVYRL VLTAMDGGDP VRSSVAQILV TVLDVNDNTP MFTQPVYRVS VPENLPVGTP VLAVTATDQD EGVHGEVTYS FVKITEKISQ IFCLNVLTGE ISTSANLDYE DSSFYELGVE ARDGPGLRDR AKVLITILDV NDNVPEVVVT SGSRTIAESA PPGTVIALFQ VFDRDSGLNG LVTCSIPRSL PFELEKSVGN YYRLVTNAAL DREEVFLYNI TVTATDKGTP PLSTETIISL NVADTNDNPP TFPHSSYSVY VLENNPRGAS IFSVNALDPD VDQNAQVSYS LAEDTLQGAP LSSYVSINSD TGILYALRSF DYEQLRDLQL WVTASDSGDP PLSSNVSLSL FVLDQNDNAP EILYPALPTD GSTGVELAPR SAEPGYLVTK VVAVDRDSGQ NAWLSYRLLK ASEPGLFSVG LHTGEVRTAR ALLDRDALKQ SLVVAVQDHG QPPLSATVTL TVAVADRIPD ILADLGSLEP SAKPNDSDLT LYLVVAVAAV SCVFLAFVIV LLALRLQRWH KSRLLQASGG GLASMPGSHF VGVEGVRAFL QTYSHEVSLT ADSRKSHLIF PQPNYADTLI NQESYEKSEP LLITQDLLET KGEPRQLQQA PPNTDWRFSQ AQRPGTSGSQ NGDDTGTWPN NQFDTEMLQA MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK