PCDG5_HUMAN » Protocadherin gamma-A5

PCDG5_HUMAN » Protocadherin gamma-A5
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDG5_HUMAN » Protocadherin gamma-A5 » PCDH-gamma-A5;
Hydrophobic Thickness 38.8 ± 4.4 Å
Tilt Angle 29 ± 5°
ΔGtransfer -32.5 kcal/mol
ΔGfold -30.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 687-716 (684-717)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 4ZPS, Subunit A, Seq Identity:82%, Cadherin-like

AA: 138-233, PDBID: 4ZPS, Subunit A, Seq Identity:63%, Cadherin domain

AA: 247-338, PDBID: 4ZI9, Subunit B, Seq Identity:57%, Cadherin domain

AA: 352-443, PDBID: 4ZPL, Subunit A, Seq Identity:34%, Cadherin domain

AA: 457-553, PDBID: 2WCP, Subunit A, Seq Identity:34%, Cadherin domain

AA: 578-665, PDBID: 3UBH, Subunit A, Seq Identity:31%, Cadherin domain

AA: 688-772, Cadherin cytoplasmic C-terminal

AA: 809-931, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDG5_HUMAN » Protocadherin gamma-A5
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDG5_HUMAN » Protocadherin gamma-A5
SIGNAL 1 29 Potential.
CHAIN 30 931 Protocadherin gamma-A5.
DOMAIN 30 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 347 Cadherin 3.
DOMAIN 348 452 Cadherin 4.
DOMAIN 453 562 Cadherin 5.
DOMAIN 570 683 Cadherin 6.
Amino Acid Sequence for PCDG5_HUMAN » Protocadherin gamma-A5
MASPPRGWGC GELLLPFMLL GTLCEPGSGQ IRYSMPEELD KGSFVGNIAK DLGLEPQELA ERGVRIVSRG RTQLFALNPR SGSLVTAGRI DREELCAQSP LCVVNFNILV ENKMKIYGVE VEIIDINDNF PRFRDEELKV KVNENAAAGT RLVLPFARDA DVGVNSLRSY QLSSNLHFSL DVVSGTDGQK YPELVLEQPL DREKETVHDL LLTALDGGDP VLSGTTHIRV TVLDANDNAP LFTPSEYSVS VPENIPVGTR LLMLTATDPD EGINGKLTYS FRNEEEKISE TFQLDSNLGE ISTLQSLDYE ESRFYLMEVV AQDGGALVAS AKVVVTVQDV NDNAPEVILT SLTSSISEDC LPGTVIALFS VHDGDSGENG EIACSIPRNL PFKLEKSVDN YYHLLTTRDL DREETSDYNI TLTVMDHGTP PLSTESHIPL KVADVNDNPP NFPQASYSTS VTENNPRGVS IFSVTAHDPD SGDNARVTYS LAEDTFQGAP LSSYVSINSD TGVLYALRSF DYEQLRDLQL WVTASDSGNP PLSSNVSLSL FVLDQNDNTP EILYPALPTD GSTGVELAPR SAEPGYLVTK VVAVDKDSGQ NAWLSYRLLK ASEPGLFAVG LHTGEVRTAR ALLDRDALKQ SLVVAVEDHG QPPLSATFTV TVAVADRIPD ILADLGSIKT PIDPEDLDLT LYLVVAVAAV SCVFLAFVIV LLVLRLRRWH KSRLLQAEGS RLAGVPASHF VGVDGVRAFL QTYSHEVSLT ADSRKSHLIF PQPNYADTLL SEESCEKSEP LLMSDKVDAN KEERRVQQAP PNTDWRFSQA QRPGTSGSQN GDDTGTWPNN QFDTEMLQAM ILASASEAAD GSSTLGGGAG TMGLSARYGP QFTLQHVPDY RQNVYIPGSN ATLTNAAGKR DGKAPAGGNG NKKKSGKKEK K