PCDG4_HUMAN » Protocadherin gamma-A4

PCDG4_HUMAN » Protocadherin gamma-A4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDG4_HUMAN » Protocadherin gamma-A4 » PCDH-gamma-A4;
Hydrophobic Thickness 40.4 ± 1.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -49.5 kcal/mol
ΔGfold -26.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 689-716 (684-717)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 4ZPS, Subunit A, Seq Identity:72%, Cadherin-like

AA: 138-233, PDBID: 4ZPS, Subunit A, Seq Identity:63%, Cadherin domain

AA: 247-338, PDBID: 4ZI9, Subunit B, Seq Identity:59%, Cadherin domain

AA: 352-443, PDBID: 4ZPL, Subunit A, Seq Identity:36%, Cadherin domain

AA: 457-553, PDBID: 2WCP, Subunit A, Seq Identity:33%, Cadherin domain

AA: 578-665, PDBID: 4ZPL, Subunit A, Seq Identity:32%, Cadherin domain

AA: 688-772, Cadherin cytoplasmic C-terminal

AA: 809-931, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDG4_HUMAN » Protocadherin gamma-A4
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDG4_HUMAN » Protocadherin gamma-A4
SIGNAL 1 28 Potential.
CHAIN 29 931 Protocadherin gamma-A4.
DOMAIN 29 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 347 Cadherin 3.
DOMAIN 348 452 Cadherin 4.
DOMAIN 453 567 Cadherin 5.
DOMAIN 570 682 Cadherin 6.
Amino Acid Sequence for PCDG4_HUMAN » Protocadherin gamma-A4
MAAPPARPDH TRLLQICLLL GVLVEIRAEQ ILYSVFEEQE EGSVVGNIAK DLGLAPRELA ERGVRIVSRG RTQLFALNPR SGTLVTAGRI DREELCDRSP NCVTNLEILL EDTVKILRVE VEIIDVNDNP PSFGTEQREI KVAENENPGA RFPLPEAFDP DVGVNSLQGY QLNSNGYFSL DVQSGADGIK YPELVLERAL DREEEAVHHL VLTAFDGGDP VRSGTARILI ILVDTNDNAP VFTQPEYHVS VRENVPVGTR LLTVKATDPD EGANGDVTYS FRKVRDKISQ LFQLNSLSGD ITILGGLDYE DSGFYDIDVE AHDGPGLRAR SKVLVTVLDE NDNAPEVTVT SLTSSVQESS SPGTVIALFN VHDSDSGGNG LVTCSIPDNL PFTLEKTYGN YYRLLTHRTL DREEVSEYNI TVTATDQGTP PLSTETHISL QVMDINDNPP TFPHASYSAY IPENNPRGAS ILSMTAQDPD SGDNARITYS LAEDTFQGAP LSSYVSINSN TGILYALCSF DYEQFRDLQL LMTASDSGDP PLSSNVSLSL FVLDQNDNVP EILYPTFPTD GSTGVELAPR SADSGYLVTK VVAVDRDSGQ NAWLSYSLLK SSEPGLFAVG LHTGEVRTAR ALLDRDALKQ RLVVVVQDHG QPPLSATVTL TVAVADSIPD VLADLGSLKP SADPDDSGLT LYLVVAVAAV SCVFLAFVTV LLALKLRRWH KSRLLHAEGS RLAGVPASHF VGVDGVRAFL QTYSHEVSLT ADSRKSHLIF SQPSYADTLI SRESCEKSEP LLITQDLLET KGDPNLQQAP PNTDWRFSQA QRPGTSGSQN GDDTGTWPNN QFDTEMLQAM ILASASEAAD GSSTLGGGAG TMGLSARYGP QFTLQHVPDY RQNVYIPGSN ATLTNAAGKR DGKAPAGGNG NKKKSGKKEK K