PCDG3_HUMAN » Protocadherin gamma-A3

PCDG3_HUMAN » Protocadherin gamma-A3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDG3_HUMAN » Protocadherin gamma-A3 » PCDH-gamma-A3;
Hydrophobic Thickness 35.6 ± 1.4 Å
Tilt Angle 1 ± 1°
ΔGtransfer -46.9 kcal/mol
ΔGfold -28.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 689-716 (686-717)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 4ZPS, Subunit A, Seq Identity:81%, Cadherin-like

AA: 247-338, PDBID: 4ZI9, Subunit B, Seq Identity:55%, Cadherin domain

AA: 352-443, PDBID: 4ZPL, Subunit A, Seq Identity:36%, Cadherin domain

AA: 457-553, PDBID: 2WCP, Subunit A, Seq Identity:33%, Cadherin domain

AA: 578-665, PDBID: 4ZPM, Subunit A, Seq Identity:31%, Cadherin domain

AA: 688-772, Cadherin cytoplasmic C-terminal

AA: 810-932, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDG3_HUMAN » Protocadherin gamma-A3
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDG3_HUMAN » Protocadherin gamma-A3
SIGNAL 1 29 Potential.
CHAIN 30 932 Protocadherin gamma-A3.
DOMAIN 30 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 347 Cadherin 3.
DOMAIN 348 452 Cadherin 4.
DOMAIN 453 562 Cadherin 5.
DOMAIN 570 682 Cadherin 6.
Amino Acid Sequence for PCDG3_HUMAN » Protocadherin gamma-A3
MTNCLSFRNG RGLALLCALL GTLCETGSSQ IRYSVSEELD KGSFVGNIAN DLGLEPRELA ERGVRIVSRG RTQLFSLNPQ SGSLVTAERI DREELCAQIP LCLVKINILV EDKLKIFEVE IEIKDINDNA PNFPTEELEI KIGELTVPGT RFPIKTAFDP DVGINSLQNY KLSPNDYFSL AVNSVSEGAK YPELVLERAL DREKKEIHQL VLVASDGGDP VHSGNLHIQV IVLDANDNPP MFTQPEYRVS VWENVPVGTR LLTVNATDPD EGFNAQVSYI LDKMPGKIAE IFHLNSVSGE VSILKSLDYE DAMFYEIKIE AQDGPGLLSR AKILVTVLDV NDNAPEITIT SLTSSVPEEG TVGREIALID VHDRDSGQNG QVEVFVLGNL PFKLEKSIDQ YYRLVTATSL DREQISEYNI SLRASDGGSP PLSTETHITL HVIDINDNPP TFPHLSYSAY IPENNPRGAS IFSVTAQDPD SNNNARITYA LTEDTLQGAP LSSFVSINSN TGVLYALRSF DYEQFRDLKL LVTASDSGNP PLSSNVSLNL FVLDQNDNAP EILYPALPTD GSTGVELAPR SAEPGYLVTK VVAVDRDSGQ NAWLSYRLLK ASEPGLFSVG LHTGEVRTAR ALLDRDALKQ SLVVAIQDHG QPPLSATVTL IVAVADRIPD ILADLGSLEP SAKPNDSDLT LYLVVAVAAV SCVFLAFVIV LLALRLRRWH KSRLLQASGG GLASTPGSHF VGADGVRAFL QTYSHEVSLT ADSRKSHLIF PQPNYADTLI SQESCEKSEP LLITQDLLEM KGDSNLLQQA PPNTDWRFSQ AQRPGTSGSQ NGDDTGTWPN NQFDTEMLQA MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK