PCDG2_HUMAN » Protocadherin gamma-A2

PCDG2_HUMAN » Protocadherin gamma-A2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDG2_HUMAN » Protocadherin gamma-A2 » PCDH-gamma-A2;
Hydrophobic Thickness 38.0 ± 1.4 Å
Tilt Angle 0 ± 3°
ΔGtransfer -52.7 kcal/mol
ΔGfold -26.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 689-716 (686-717)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 4ZPS, Subunit A, Seq Identity:78%, Cadherin-like

AA: 138-233, PDBID: 4ZPS, Subunit A, Seq Identity:60%, Cadherin domain

AA: 247-338, PDBID: 4ZI9, Subunit B, Seq Identity:46%, Cadherin domain

AA: 352-443, PDBID: 4ZPM, Subunit A, Seq Identity:34%, Cadherin domain

AA: 457-553, PDBID: 2WCP, Subunit A, Seq Identity:34%, Cadherin domain

AA: 578-665, PDBID: 4ZPM, Subunit A, Seq Identity:31%, Cadherin domain

AA: 688-772, Cadherin cytoplasmic C-terminal

AA: 810-932, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDG2_HUMAN » Protocadherin gamma-A2
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDG2_HUMAN » Protocadherin gamma-A2
SIGNAL 1 28 Potential.
CHAIN 29 932 Protocadherin gamma-A2.
DOMAIN 29 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 347 Cadherin 3.
DOMAIN 348 452 Cadherin 4.
DOMAIN 453 562 Cadherin 5.
DOMAIN 570 682 Cadherin 6.
Amino Acid Sequence for PCDG2_HUMAN » Protocadherin gamma-A2
MAALQKLPHC RKLVLLCFLL ATLWEARAGQ IRYSVREEID RGSFVGNIAK DLGLEPLALA EQGVRIVSRG RSQLFALNPR SGSLVTANRI DREELCAQSA PCLLNFNILL EDKLTIYSVE VEITDINDNA PRFGVEELEL KISETTTPGF RIPLKNAHDA DVGENALQKY ALNPNDHFSL DVRRGADGNK YPELVLERSL DREEEAVHHL VLVASDGGDP VLSGTSRICV KVLDANDNAP VFTQPEYRIS IPENTLVGTR ILTVTATDAD EGYYAQVVYF LEKSPGETSE VFELKSTSGE LTIIKDLDYE DATFHEIDIE AQDGPGLLTR AKVIVTVLDV NDNAPEFYMT SATSSVSEDS LPGTIIGLFN VHDRDSGQNA FTTCSLPEDL PFKLEKSVDN YYRLVTTRAL DREQFSFYNI TLTAKDGGNP SLSTDAHILL QVADINDNAP AFSRTSYSTY IPENNPRGAS VFSVTAHDPD SNDNAHVTYS FAEDTVQGAP LSSYISINSD TGVLYALRSF DYEQLRDLQV WVIARDSGNP PLSSNVSLSL FVLDQNDNAP EILYPAFPTD GSTGVELAPR SAEPGYLVTK VVAVDRDSGQ NAWLSYHLLK ASEPGLFSVG LHTGEVRTAR ALLDRDALKQ SLVVAIQDHG QPPLSATVTL TVAVADRIPD ILADLGSLEP SAIPNDSDLT LYLVVAVAAV SCVFLAFVIV LLAHRLRRWH KSRLLQASGG SLTGMQSSHF VGVDGVRAFL QTYSHEVSLT ADSRKSHLIF PQPNYADTLI SQESCEKKDF LSAPQSLLEE EREETFSQQA PPNTDWRFSQ AQRPGTSGSQ NGDDTGTWPN NQFDTEMLQA MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK