PCDG1_HUMAN » Protocadherin gamma-A1

PCDG1_HUMAN » Protocadherin gamma-A1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDG1_HUMAN » Protocadherin gamma-A1 » PCDH-gamma-A1;
Hydrophobic Thickness 39.2 ± 4.4 Å
Tilt Angle 12 ± 5°
ΔGtransfer -29.6 kcal/mol
ΔGfold -25.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 689-714 (686-717)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 4ZI9, Subunit A, Seq Identity:80%, Cadherin-like

AA: 138-233, PDBID: 4ZPS, Subunit A, Seq Identity:65%, Cadherin domain

AA: 247-338, PDBID: 4ZI9, Subunit B, Seq Identity:79%, Cadherin domain

AA: 352-443, PDBID: 4ZPL, Subunit A, Seq Identity:36%, Cadherin domain

AA: 457-553, PDBID: 2WCP, Subunit A, Seq Identity:32%, Cadherin domain

AA: 579-665, PDBID: 4ZPS, Subunit A, Seq Identity:32%, Cadherin domain

AA: 688-772, Cadherin cytoplasmic C-terminal

AA: 809-931, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDG1_HUMAN » Protocadherin gamma-A1
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDG1_HUMAN » Protocadherin gamma-A1
SIGNAL 1 28 Potential.
CHAIN 29 931 Protocadherin gamma-A1.
DOMAIN 29 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 347 Cadherin 3.
DOMAIN 348 452 Cadherin 4.
DOMAIN 453 562 Cadherin 5.
DOMAIN 570 682 Cadherin 6.
Amino Acid Sequence for PCDG1_HUMAN » Protocadherin gamma-A1
MKIQKKLTGC SRLMLLCLSL ELLLEAGAGN IHYSVPEETD KGSFVGNIAK DLGLQPQELA DGGVRIVSRG RMPLFALNPR SGSLITARRI DREELCAQSM PCLVSFNILV EDKMKLFPVE VEIIDINDNT PQFQLEELEF KMNEITTPGT RVSLPFGQDL DVGMNSLQSY QLSSNPHFSL DVQQGADGPQ HPEMVLQSPL DREEEAVHHL ILTASDGGEP VRSGTLRIYI QVVDANDNPP AFTQAQYHIN VPENVPLGTQ LLMVNATDPD EGANGEVTYS FHNVDHRVAQ IFRLDSYTGE ISNKEPLDFE EYKMYSMEVQ AQDGAGLMAK VKVLIKVLDV NDNAPEVTIT SVTTAVPENF PPGTIIALIS VHDQDSGDNG YTTCFIPGNL PFKLEKLVDN YYRLVTERTL DRELISGYNI TITAIDQGTP ALSTETHISL LVTDINDNSP VFHQDSYSAY IPENNPRGAS IFSVRAHDLD SNENAQITYS LIEDTIQGAP LSAYLSINSD TGVLYALRSF DYEQFRDMQL KVMARDSGDP PLSSNVSLSL FLLDQNDNAP EILYPALPTD GSTGVELAPL SAEPGYLVTK VVAVDRDSGQ NAWLSYRLLK ASEPGLFSVG LHTGEVRTAR ALLDRDALKQ SLVVAVQDHG QPPLSATVTL TVAVADRISD ILADLGSLEP SAKPNDSDLT LYLVVAAAAV SCVFLAFVIV LLAHRLRRWH KSRLLQASGG GLASMPGSHF VGVDGVRAFL QTYSHEVSLT ADSRKSHLIF PQPNYADTLI SQESCEKKGF LSAPQSLLED KKEPFSQQAP PNTDWRFSQA QRPGTSGSQN GDDTGTWPNN QFDTEMLQAM ILASASEAAD GSSTLGGGAG TMGLSARYGP QFTLQHVPDY RQNVYIPGSN ATLTNAAGKR DGKAPAGGNG NKKKSGKKEK K