PCDC2_HUMAN » Protocadherin alpha-C2

PCDC2_HUMAN » Protocadherin alpha-C2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDC2_HUMAN » Protocadherin alpha-C2 » PCDH-alpha-C2;
Hydrophobic Thickness 35.2 ± 3.8 Å
Tilt Angle 44 ± 3°
ΔGtransfer -30.9 kcal/mol
ΔGfold -29.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 703-733 (701-737)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 43-127, PDBID: 4ZPM, Subunit B, Seq Identity:97%, Cadherin-like

AA: 153-248, PDBID: 4ZPM, Subunit A, Seq Identity:97%, Cadherin domain

AA: 262-356, PDBID: 4ZPM, Subunit A, Seq Identity:92%, Cadherin domain

AA: 371-460, PDBID: 4ZPL, Subunit A, Seq Identity:34%, Cadherin domain

AA: 474-570, PDBID: 4ZPL, Subunit A, Seq Identity:32%, Cadherin domain

AA: 593-681, PDBID: 4ZPL, Subunit A, Seq Identity:33%, Cadherin domain

AA: 703-810, Cadherin cytoplasmic C-terminal

AA: 857-990, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDC2_HUMAN » Protocadherin alpha-C2
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDC2_HUMAN » Protocadherin alpha-C2
SIGNAL 1 42 Potential.
CHAIN 43 1007 Protocadherin alpha-C2.
DOMAIN 43 148 Cadherin 1.
DOMAIN 149 257 Cadherin 2.
DOMAIN 258 365 Cadherin 3.
DOMAIN 374 469 Cadherin 4.
DOMAIN 470 579 Cadherin 5.
DOMAIN 594 691 Cadherin 6.
REPEAT 856 859 PXXP 1.
REPEAT 889 892 PXXP 2.
REPEAT 930 933 PXXP 3.
REPEAT 948 951 PXXP 4.
REGION 856 951 4 X 4 AA repeats of P-X-X-P.
Amino Acid Sequence for PCDC2_HUMAN » Protocadherin alpha-C2
MEQAGTRPAA TEHPRLRRPM PWLLLLPLLL LLLLLLPGPA ASQLRYSVPE EQAPGALVGN VARALGLELR RLGPGCLRIN HLGAPSPRYL ELDLTSGALF VNERIDREAL CEQRPRCLLS LEVLAHNPVA VSAVEVEILD INDNSPRFPR PNYQLQVSES VAPGARFHIE SAQDPDVGAN SVQTYELSPS EHFELDLKPL QENSKVLELV LRKGLDREQA ALHHLVLTAV DGGIPARSGT AQISVRVLDT NDNSPAFDQS TYRVQLREDS PPGTLVVKLN ASDPDEGSNG ELRYSLSSYT SDRERQLFSI DASTGEVRVI GGLDYEEASS YQIYVQATDR GPVPMAGHCK VLVDIVDVND NAPEVVLTDL YSPVPENATP NTIVAVLSVN DQDSGPNRKV SLGLEATLPF RLNGFGNSYT LVVSGPLDRE RVAVYNITVT ATDGGIPQLT SLRTLKVEIS DINDNPPSFL EDSYSIYIQE NNLPGVLLCT VQATDPDEKE NAEVTYSLLE REIQGLPVTS YVSINSASGS LYAVNSFDYE KFREFFVTVE AQDKGSPPLS STVTANVYVV DMNDHAPHIL YPTSTNSSAA FEMVPRTAPA GYLVTKVIAM DSDSGQNAWL FYHLAQTSDL DLFKVELHTG EIRTTRKMGD ESGSTFNLTV VVRDNGEPSL SASVAITVAV VDRVSKILPD TQRHVKSPRT YSEITLYLII ALSTVSFIFL LTIIILSIIK CYRYTAYGTA CCGGFCGVRE RSPAELYKQA NNNIDARIPH GLKVQPHFIE VRGNGSLTKT YCYKACLTAG SGSDTFMFYN TGAQTGPGPS GAQAAVTDSR NLTGQSGQNA GNLIILKNEA VSQNEPRQPN PDWRYSASLR AGMHSSVHLE EAGILRAGPG GPDQQWPTVS SATPEPEAGE VSPPVGAGVN SNSWTFKYGP GNPKQSGPGE LPDKFIIPGS PAIISIRQEP TNSQIDKSDF ITFGKKEETK KKKKKKKGNK TQEKKEKGNS TTDNSDQ