PCDC1_HUMAN » Protocadherin alpha-C1

PCDC1_HUMAN » Protocadherin alpha-C1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDC1_HUMAN » Protocadherin alpha-C1 » PCDH-alpha-C1;
Hydrophobic Thickness 37.2 ± 1.6 Å
Tilt Angle 0 ± 1°
ΔGtransfer -41.6 kcal/mol
ΔGfold -22.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 682-707 (679-710)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 21-103, PDBID: 4ZPN, Subunit A, Seq Identity:43%, Cadherin-like

AA: 129-224, PDBID: 4ZPM, Subunit A, Seq Identity:53%, Cadherin domain

AA: 238-331, PDBID: 4ZPM, Subunit A, Seq Identity:39%, Cadherin domain

AA: 346-436, PDBID: 4ZPL, Subunit A, Seq Identity:39%, Cadherin domain

AA: 450-546, PDBID: 4ZPN, Subunit B, Seq Identity:36%, Cadherin domain

AA: 568-657, PDBID: 2EE0, Subunit A, Seq Identity:29%, Cadherin domain

AA: 680-771, Cadherin cytoplasmic C-terminal

AA: 813-946, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDC1_HUMAN » Protocadherin alpha-C1
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDC1_HUMAN » Protocadherin alpha-C1
SIGNAL 1 18 Potential.
CHAIN 19 963 Protocadherin alpha-C1.
DOMAIN 19 124 Cadherin 1.
DOMAIN 125 233 Cadherin 2.
DOMAIN 234 340 Cadherin 3.
DOMAIN 349 445 Cadherin 4.
DOMAIN 446 555 Cadherin 5.
DOMAIN 570 667 Cadherin 6.
REPEAT 812 815 PXXP 1.
REPEAT 845 848 PXXP 2.
REPEAT 886 889 PXXP 3.
REPEAT 904 907 PXXP 4.
REGION 812 907 4 X 4 AA repeats of P-X-X-P.
Amino Acid Sequence for PCDC1_HUMAN » Protocadherin alpha-C1
MVGCGVAVLC LWVSCGAAAG QLEYSVPEET ERGVAVGNLS ADLRLPAAAM SSRNFRFLSS HRELYFGVDL PSGNLVVREP ADREQLCRAK AACVLTYDLV LEDPLELHKI RIHVLDTNDN SPLFPAGDVQ LHIPEFLTPG ARFTLPNAQD DDEGSNGILS YSLSPSQHFR LDMGSRVDGS EYPELVLEKA LDREQRATHL LVLTARDGGL PARSGDAQVT IIVVDTNDNA PVFERSVYRT KVPETAPNGT VLFRVQALDP DEGSNGEVQY SLSNSTQAEL RHRFHVHPKS GEVQVAASLG PPETLLEAYI EARDEGVFGL ASTAKLLVEV TDVNDHAPEL DFLTLSNPVP EDAAPGTVIA LFSVKDEDLD SNGRVICGMS SAGPFQLTAS FDNYYSLLID GPLDREQISE YQVLITASDS GSPPLSTRRT ITVSVADVND NTPNFPQPQQ ELFVAENNGP GASLGRVFAQ DPDLGKNGLV SYELLDVISE GPSASSLLAV ESSSGAITAK TSFDFEQLRG FHFQVEGRDG GIPPRSATVT INLFVVDRND NYPVILFPLP RNGSVPVEIV PRSARTGHLV TKVVAEDADS GSNAWLSYHI SRASDSSLFR ISANIGELRT ARLVLPTDAV KQRVVVVVRD HGDPPLSSSV TLGVLLSNSV PQLLPDFEDV WEPGGQLSAQ NLYLVIALAC ISFLFLGCLL FFVCTKLHQS PGCCAQSCCR STEDLRYGSK MVSNPCMTSA TIDVTTVERL SQTYLYRASL GLGSDNNSLL LRGEYNAADL RNLATGVGLN LPISCIQIRN RKGDHANVNA MPRQPNPDWR YSASLRAGMH SSVHLEEAGI LRAGPGGPDQ QWPTVSSATP EPEAGEVSPP VGAGVNSNSW TFKYGPGNPK QSGPGELPDK FIIPGSPAII SIRQEPTNSQ IDKSDFITFG KKEETKKKKK KKKGNKTQEK KEKGNSTTDN SDQ