PCDBG_HUMAN » Protocadherin beta-16

PCDBG_HUMAN » Protocadherin beta-16
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDBG_HUMAN » Protocadherin beta-16 » PCDH-beta-16; Protocadherin-3X;
Hydrophobic Thickness 37.6 ± 5.2 Å
Tilt Angle 34 ± 3°
ΔGtransfer -27.2 kcal/mol
ΔGfold -22.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 686-715 (680-717)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 1WYJ, Subunit A, Seq Identity:64%, Cadherin-like

AA: 139-233, PDBID: 4ZPL, Subunit A, Seq Identity:48%, Cadherin domain

AA: 247-338, PDBID: 4ZPL, Subunit A, Seq Identity:50%, Cadherin domain

AA: 353-442, PDBID: 4ZPL, Subunit A, Seq Identity:35%, Cadherin domain

AA: 456-552, PDBID: 4ZPL, Subunit A, Seq Identity:32%, Cadherin domain

AA: 575-663, PDBID: 3UBH, Subunit A, Seq Identity:33%, Cadherin domain

AA: 685-768, Cadherin cytoplasmic C-terminal

UniProt annotation for PCDBG_HUMAN » Protocadherin beta-16
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDBG_HUMAN » Protocadherin beta-16
SIGNAL 1 28 Potential.
CHAIN 29 776 Protocadherin beta-16.
DOMAIN 35 133 Cadherin 1.
DOMAIN 138 242 Cadherin 2.
DOMAIN 247 347 Cadherin 3.
DOMAIN 352 451 Cadherin 4.
DOMAIN 456 561 Cadherin 5.
DOMAIN 568 671 Cadherin 6.
Amino Acid Sequence for PCDBG_HUMAN » Protocadherin beta-16
MEIGWMHNRR QRQVLVFFVL LSLSGAGAEL GSYSVVEETE RGSFVANLGK DLGLGLTEMS TRKARIISQG NKQHLQLKAQ TGDLLINEKL DREELCGPTE PCILHFQVLM ENPLEIFQAE LRVIDINDHS PMFTEKEMIL KIPENSPLGT EFPLNHALDL DVGSNNVQNY KISPSSHFRV LIHEFRDGRK YPELVLDKEL DREEEPQLRL TLTALDGGSP PRSGTAQVRI EVVDINDNAP EFEQPIYKVQ IPENSPLGSL VATVSARDLD GGANGKISYT LFQPSEDISK TLEVNPMTGE VRLRKQVDFE MVTSYEVRIK ATDGGGLSGK CTLLLQVVDV NDNPPQVTMS ALTSPIPENS PEIVVAVFSV SDPDSGNNGK TISSIQEDLP FLLKPSVKNF YTLVTERALD REARAEYNIT LTVTDMGTPR LKTEHNITVQ ISDVNDNAPT FTQTSYTLFV RENNSPALHI GSVSATDRDS GTNAQVTYSL LPPQDPHLPL ASLVSINADN GHLFALRSLD YEALREFEFR VGATDRGSPA LSSEALVRVL VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKQRL VVLVKDNGEP PRSATATLHV LLVDGFSQPF LPLPEAAPGQ TQANSLTVYL VVALASVSSL FLFSVLLFVA VRLCRRSRAA SVGRCSMPEG PFPGRLVDVS GTGTLSQSYQ YEVCLTGGSE TSEFKFLKPI IPNFSP