PCDBE_HUMAN » Protocadherin beta-14

PCDBE_HUMAN » Protocadherin beta-14
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDBE_HUMAN » Protocadherin beta-14 » PCDH-beta-14;
Hydrophobic Thickness 38.4 ± 2.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -52.8 kcal/mol
ΔGfold -22.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 685-714 (683-720)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 1WYJ, Subunit A, Seq Identity:59%, Cadherin-like

AA: 138-233, PDBID: 4ZPL, Subunit A, Seq Identity:56%, Cadherin domain

AA: 247-338, PDBID: 4ZPL, Subunit A, Seq Identity:46%, Cadherin domain

AA: 352-442, PDBID: 4ZPL, Subunit A, Seq Identity:37%, Cadherin domain

AA: 456-552, PDBID: 4ZPL, Subunit A, Seq Identity:31%, Cadherin domain

AA: 575-663, PDBID: 3UBH, Subunit A, Seq Identity:33%, Cadherin domain

AA: 685-768, Cadherin cytoplasmic C-terminal

UniProt annotation for PCDBE_HUMAN » Protocadherin beta-14
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDBE_HUMAN » Protocadherin beta-14
SIGNAL 1 26 Potential.
CHAIN 27 798 Protocadherin beta-14.
DOMAIN 35 133 Cadherin 1.
DOMAIN 138 242 Cadherin 2.
DOMAIN 247 347 Cadherin 3.
DOMAIN 352 451 Cadherin 4.
DOMAIN 456 561 Cadherin 5.
DOMAIN 568 671 Cadherin 6.
DISULFID 96 102 By similarity.
Amino Acid Sequence for PCDBE_HUMAN » Protocadherin beta-14
MEIRGALDLR KRQVLIFLVL LGLSRAGTES AHYSVAEETE IGSFVANLAR DLGLGVEELS SREARVVSDD NKKYLHLDLL TGNLLLNEKL DRDELCGSTE PCVLHFQVVL ENPLQFFRFE LCVKDINDHS PTFLDKEILI KISEGTTVGA TFLMESAQDL DVGSNSLQNY TISPNSHFYI KIPDSSDRKI YPELVLDRAL DYEQEAELRL TLTAVDGGSP PKSGTTLVLI KVLDINDNAP EFPQSLYEVQ VPEDRPLGSW IATISAKDLD AGNYGKISYT FFHASEDIRK TFEINPISGE VNLRSPLDFE VIQSYTINIQ ATDGGGLSGK CTLLVKVMDI NDNPPEVTIS SITKRIPENA SETLVALFSI LDQDSGDNGR MICSIQDNLP FFLKPTFKNF FTLVSEKALD RESQAEYNIT ITVTDLGTPR LKTEYNITVL LSDVNDNAPT FTQTSYTLFV RENNSPALHI GSVSATDRDS GTNAQVNYSL LPPQDRHLPL ASLVSINADN GHLFALRSLD YEALQEFEFR VGATDRGSPA LSSEALVRVL VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP PRSATATLHV LLVDGFSQPY LPLPEAAPAQ AQADSLTVYL VVALASVSSL FLFSVLLFVA VRLCRRSRAA SVGRCSVPEG PFPGHLVDVS GTGTLSQSYQ YEVCLTGGSG TNEFKFLKPI IPNFQVHDTG RNMGEIENFR NSFGLNIQ