PCDBC_HUMAN » Protocadherin beta-12

PCDBC_HUMAN » Protocadherin beta-12
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDBC_HUMAN » Protocadherin beta-12 » PCDH-beta-12;
Hydrophobic Thickness 38.4 ± 2.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -52.8 kcal/mol
ΔGfold -22.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 685-714 (683-720)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 1WYJ, Subunit A, Seq Identity:56%, Cadherin-like

AA: 139-233, PDBID: 4ZPL, Subunit A, Seq Identity:49%, Cadherin domain

AA: 247-338, PDBID: 4ZPL, Subunit A, Seq Identity:46%, Cadherin domain

AA: 352-442, PDBID: 4ZPL, Subunit A, Seq Identity:36%, Cadherin domain

AA: 456-552, PDBID: 1EDH, Subunit B, Seq Identity:28%, Cadherin domain

AA: 576-663, PDBID: 3UBH, Subunit A, Seq Identity:34%, Cadherin domain

AA: 685-768, Cadherin cytoplasmic C-terminal

UniProt annotation for PCDBC_HUMAN » Protocadherin beta-12
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDBC_HUMAN » Protocadherin beta-12
SIGNAL 1 26 Potential.
CHAIN 27 795 Protocadherin beta-12.
DOMAIN 35 133 Cadherin 1.
DOMAIN 138 242 Cadherin 2.
DOMAIN 247 347 Cadherin 3.
DOMAIN 352 451 Cadherin 4.
DOMAIN 456 561 Cadherin 5.
DOMAIN 568 671 Cadherin 6.
Amino Acid Sequence for PCDBC_HUMAN » Protocadherin beta-12
MENGGAGTLQ IRQVLLFFVL LGMSQAGSET GNFLVMEELQ SGSFVGNLAK TLGLEVSELS SRGARVVSND NKECLQLDTN TGDLLLREML DREELCGSNE PCVLYFQVLM KNPTQFLQIE LQVRDINDHS PVFLEKEMLL EIPENSPVGA VFLLESAKDL DVGINAVKSY TINPNSHFHV KIRVNPDNRK YPELVLDKAL DYEERPELSF ILTALDGGSP PRSGTALVRV VVVDINDNSP EFEQAFYEVK ILENSILGSL VVTVSAWDLD SGTNSELSYT FSHASEDIRK TFEINQKSGD ITLTAPLDFE AIESYSIIIQ ATDGGGLFGK STVRIQVMDV NDNAPEITVS SITSPIPENT PETVVMVFRI RDRDSGDNGK MVCSIPEDIP FVLKSSVNNY YTLETERPLD RESRAEYNIT ITVTDLGTPR LKTEHNITVL VSDVNDNAPA FTQTSYALFV RENNSPALHI GSISATDRDS GTNAQVNYSL LPSQDPHLPL ASLVSINADN GHLFALRSLD YEALQGFQFR VGATDHGSPA LSSEALVRVL VLDANDNSPF VLYPLQNGSA PCTELVPWAA EPGYLVTKVV AVDGDSGQNA WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP PRSATATLHV LLVDGFSQPY LPLPEAAPAQ AQADSLTVYL VVALASVSSL FLFSVLLFVA VRLCRRSRAA PVGRCSVPEG PFPGHLVDVS GTGTLSQSYH YEVCVTGGSR SNKFKFLKPI IPNFLPQSTG SEVEENPPFQ NNLGF