PCDBA_HUMAN » Protocadherin beta-10

PCDBA_HUMAN » Protocadherin beta-10
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDBA_HUMAN » Protocadherin beta-10 » PCDH-beta-10;
Hydrophobic Thickness 42.8 ± 1.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -56.8 kcal/mol
ΔGfold -22.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 684-715 (684-719)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 1WYJ, Subunit A, Seq Identity:55%, Cadherin-like

AA: 138-233, PDBID: 4ZPL, Subunit A, Seq Identity:58%, Cadherin domain

AA: 247-338, PDBID: 4ZPL, Subunit A, Seq Identity:47%, Cadherin domain

AA: 352-442, PDBID: 4ZPL, Subunit A, Seq Identity:32%, Cadherin domain

AA: 456-552, PDBID: 4ZPL, Subunit A, Seq Identity:32%, Cadherin domain

AA: 575-663, PDBID: 3UBH, Subunit A, Seq Identity:33%, Cadherin domain

AA: 687-770, Cadherin cytoplasmic C-terminal

UniProt annotation for PCDBA_HUMAN » Protocadherin beta-10
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDBA_HUMAN » Protocadherin beta-10
SIGNAL 1 26
CHAIN 27 800 Protocadherin beta-10.
DOMAIN 35 133 Cadherin 1.
DOMAIN 138 242 Cadherin 2.
DOMAIN 247 347 Cadherin 3.
DOMAIN 352 451 Cadherin 4.
DOMAIN 456 561 Cadherin 5.
DOMAIN 568 671 Cadherin 6.
Amino Acid Sequence for PCDBA_HUMAN » Protocadherin beta-10
MAVRELCFPR QRQVLFLFLF WGVSLAGSGF GRYSVTEETE KGSFVVNLAK DLGLAEGELA ARGTRVVSDD NKQYLLLDSH TGNLLTNEKL DREKLCGPKE PCMLYFQILM DDPFQIYRAE LRVRDINDHA PVFQDKETVL KISENTAEGT AFRLERAQDP DGGLNGIQNY TISPNSFFHI NISGGDEGMI YPELVLDKAL DREEQGELSL TLTALDGGSP SRSGTSTVRI VVLDVNDNAP QFAQALYETQ APENSPIGFL IVKVWAEDVD SGVNAEVSYS FFDASENIRT TFQINPFSGE IFLRELLDYE LVNSYKINIQ AMDGGGLSAR CRVLVEVLDT NDNPPELIVS SFSNSVAENS PETPLAVFKI NDRDSGENGK MVCYIQENLP FLLKPSVENF YILITEGALD REIRAEYNIT ITVTDLGTPR LKTEHNITVL VSDVNDNAPA FTQTSYTLFV RENNSPALHI GSVSATDRDS GTNAQVTYSL LPPQDPHLPL ASLVSINADN GHLFALRSLD YEALQAFEFR VGATDRGSPA LSREALVRVL VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP PRSATATLHL LLVDGFSQPY LPLPEAAPAQ AQAEADLLTV YLVVALASVS SLFLLSVLLF VAVRLCRRSR AASVGRCSVP EGPFPGHLVD VRGAETLSQS YQYEVCLTGG PGTSEFKFLK PVISDIQAQG PGRKGEENST FRNSFGFNIQ