PCDB8_HUMAN » Protocadherin beta-8

PCDB8_HUMAN » Protocadherin beta-8
Magnify PCDB8_HUMAN » Protocadherin beta-8Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDB8_HUMAN » Protocadherin beta-8 » PCDH-beta-8; Protocadherin-3I;
Hydrophobic Thickness 42.8 ± 0.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -57.0 kcal/mol
ΔGfold -24.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 687-715 (683-720)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 31-113, PDBID: 1WYJ, Subunit A, Seq Identity:61%, Cadherin-like

AA: 139-234, PDBID: 4ZPL, Subunit A, Seq Identity:57%, Cadherin domain

AA: 248-339, PDBID: 4ZPL, Subunit A, Seq Identity:44%, Cadherin domain

AA: 353-443, PDBID: 4ZPL, Subunit A, Seq Identity:37%, Cadherin domain

AA: 457-553, PDBID: 4ZPL, Subunit A, Seq Identity:31%, Cadherin domain

AA: 576-664, PDBID: 3UBH, Subunit A, Seq Identity:33%, Cadherin domain

AA: 686-769, Cadherin cytoplasmic C-terminal

UniProt annotation for PCDB8_HUMAN » Protocadherin beta-8
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDB8_HUMAN » Protocadherin beta-8
SIGNAL 1 28 Potential.
CHAIN 29 801 Protocadherin beta-8.
DOMAIN 36 134 Cadherin 1.
DOMAIN 139 243 Cadherin 2.
DOMAIN 248 348 Cadherin 3.
DOMAIN 353 452 Cadherin 4.
DOMAIN 457 562 Cadherin 5.
DOMAIN 569 672 Cadherin 6.
Amino Acid Sequence for PCDB8_HUMAN » Protocadherin beta-8
MEASGKLICR QRQVLFSFLL LGLSLAGAAE PRSYSVVEET EGSSFVTNLA KDLGLEQREF SRRGVRVVSR GNKLHLQLNQ ETADLLLNEK LDREDLCGHT EPCVLRFQVL LESPFEFFQA ELQVIDINDH SPVFLDKQML VKVSESSPPG TAFPLKNAED LDIGQNNIEN YIISPNSYFR VLTRKRSDGR KYPELVLDKA LDREEEAELR LTLTALDGGS PPRSGTAQVY IEVVDVNDNA PEFEQPFYRV QISEDSPISF LVVKVSATDV DTGVNGEISY SLFQASDEIS KTFKVDFLTG EIRLKKQLDF EKFQSYEVNI EARDAGGFSG KCTVLIQVID VNDHAPEVTM SAFTSPIPEN APETVVALFS VSDLDSGENG KISCSIQEDL PFLLKSSVGN FYTLLTETPL DRESRAEYNV TITVTDLGTP RLTTHLNMTV LVSDVNDNAP AFTQTSYTLF VRENNSPALH IGSVSATDRD SGTNAQVTYS LLPPQDPHLP LASLVSINTD NGHLFALRSL DYEALQAFEF RVGASDRGSP ALSSEALVRV LVLDANDNSP FVLYPLQNGS APCTELVPRA AEPGYLVTKV VAVDGDSGQN AWLSYQLLKA TEPGLFGVWA HNGEVRTARL LSERDAAKQR LVVLVKDNGE PPCSATATLH LLLVDGFSQP YLPLPEAAPA QGQADSLTVY LVVALASVSS LFLFSVLLFV AVLLCRRSRA ASVGRCSVPE GPFPGHLVDV RGTGSLSQNY QYEVCLAGGS GTNEFQFLKP VLPNIQGHSF GPEMEQNSNF RNGFGFSLQL K