PCDB6_HUMAN » Protocadherin beta-6

PCDB6_HUMAN » Protocadherin beta-6
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDB6_HUMAN » Protocadherin beta-6 » PCDH-beta-6;
Hydrophobic Thickness 38.4 ± 2.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -52.8 kcal/mol
ΔGfold -22.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 683-712 (681-718)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 29-111, PDBID: 1WYJ, Subunit A, Seq Identity:61%, Cadherin-like

AA: 139-232, PDBID: 4ZPL, Subunit A, Seq Identity:55%, Cadherin domain

AA: 246-336, PDBID: 4ZPL, Subunit A, Seq Identity:46%, Cadherin domain

AA: 351-440, PDBID: 4ZPL, Subunit A, Seq Identity:36%, Cadherin domain

AA: 454-550, PDBID: 2WCP, Subunit A, Seq Identity:31%, Cadherin domain

AA: 573-661, PDBID: 3UBH, Subunit A, Seq Identity:33%, Cadherin domain

AA: 683-766, Cadherin cytoplasmic C-terminal

UniProt annotation for PCDB6_HUMAN » Protocadherin beta-6
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDB6_HUMAN » Protocadherin beta-6
SIGNAL 1 27 Potential.
CHAIN 28 794 Protocadherin beta-6.
DOMAIN 34 132 Cadherin 1.
DOMAIN 137 241 Cadherin 2.
DOMAIN 246 345 Cadherin 3.
DOMAIN 350 449 Cadherin 4.
DOMAIN 454 559 Cadherin 5.
DOMAIN 566 669 Cadherin 6.
Amino Acid Sequence for PCDB6_HUMAN » Protocadherin beta-6
MMQTKVQNKK RQVAFFILLM LWGEVGSESI QYSVLEETES GTFVANLTKD LGLRVGELAS RGARVVFKGN RQHLQFDPQT HDLLLNEKLD REELCGSTEP CVLPFQVLLE NPLQFFQASL RVRDINDHAP EFPAREMLLK ISEITMPGKI FPLKMAHDLD TGSNGLQRYT ISSNPHFHVL TRNRSEGRKF PELVLDKPLD REEQPQLRLT LIALDGGSPP RSGTSEIQIQ VLDINDNVPE FAQELYEAQV PENNPLGSLV ITVSARDLDA GSFGKVSYAL FQVDDVNQPF EINAITGEIR LRKALDFEEI QSYDVDVEAT DGGGLSGKCS LVVRVLDVND NAPELTMSFF ISLIPENLPE ITVAVFSVSD ADSGHNQQVI CSIENNLPFL LRPSVENFYT LVTEGALDRE SRAEYNITIT VTDLGTPRLK TQQSITVQVS DVNDNVPAFT QTSYTLFVRE NNSPALHIGS VSATDRDSGI NAQVTYSLLP PQDPHLPLSS LVSINADNGH LFALRSLDYE ALQSFEFRVG ATDRGSPALS SEALVRLLVL DANDNSPFVL YPLQNGSAPC TELVPRAAEP GYLVTKVVAV DGDSGQNAWL SYQLLKATEL GLFGVWAHNG EVRTARLLSE RDAAKHRLVV LVKDNGEPPR SATATLHVLL VDGFSQPYLP LPEAAPAQAQ ADSLTVYLVV ALASVSSLFL FSVLLFVAVR LCRRSRAASV GRYSVPEGPF PGHLVDVSGT GTLSQSYQYK VCLTGGSETN EFKFLKPIMP NFPPQGTERE MEETPTSRNS FPFS