PCDB4_HUMAN » Protocadherin beta-4

PCDB4_HUMAN » Protocadherin beta-4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDB4_HUMAN » Protocadherin beta-4 » PCDH-beta-4;
Hydrophobic Thickness 38.4 ± 2.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -52.8 kcal/mol
ΔGfold -22.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 684-713 (682-719)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 29-111, PDBID: 1WYJ, Subunit A, Seq Identity:62%, Cadherin-like

AA: 138-232, PDBID: 4ZPL, Subunit A, Seq Identity:58%, Cadherin domain

AA: 246-337, PDBID: 4ZPL, Subunit A, Seq Identity:40%, Cadherin domain

AA: 351-441, PDBID: 4ZPL, Subunit A, Seq Identity:36%, Cadherin domain

AA: 455-551, PDBID: 4ZPL, Subunit A, Seq Identity:31%, Cadherin domain

AA: 574-662, PDBID: 3UBH, Subunit A, Seq Identity:33%, Cadherin domain

AA: 684-767, Cadherin cytoplasmic C-terminal

UniProt annotation for PCDB4_HUMAN » Protocadherin beta-4
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDB4_HUMAN » Protocadherin beta-4
SIGNAL 1 27 Potential.
CHAIN 28 795 Protocadherin beta-4.
DOMAIN 34 132 Cadherin 1.
DOMAIN 137 241 Cadherin 2.
DOMAIN 246 346 Cadherin 3.
DOMAIN 351 450 Cadherin 4.
DOMAIN 455 560 Cadherin 5.
DOMAIN 567 670 Cadherin 6.
Amino Acid Sequence for PCDB4_HUMAN » Protocadherin beta-4
MKKLGRIHPN RQVLAFILMV FLSQVRLEPI RYSVLEETES GSFVAHLAKD LGLGIGELAS RSARVLSDDD KQRLQLDRQT GDLLLREKLD REELCGPIEP CVLHFQVFLE MPVQFFQGEL LIQDINDHSP IFPEREVLLK ILENSQPGTL FPLLIAEDLD VGSNGLQKYT ISPNSHFHIL TRNHSEGKKY PDLVQDKPLD REEQPEFSLT LVALDGGSPP RSGTVMVRIL IMDINDNAPE FVHTPYGVQV LENSPLDSPI VRVLARDIDA GNFGSVSYGL FQASDEIKQT FSINEVTGEI LLKKKLDFEK IKSYHVEIEA TDGGGLSGKG TVVIEVVDVN DNPPELIISS LTSSIPENAP ETVVSIFRIR DRDSGENGKM ICSIPDNLPF ILKPTLKNFY TLVTERPLDR ETSAEYNITI AVTDLGTPRL KTQQNITVQV SDVNDNAPAF TQTSYTLFVR ENNSPALHIG SVSATDRDSG TNAQVTYSLL PPQDPHLPLA SLVSINADNG HLFALRSLDY EALQAFEFRV GASDRGSPAL SSEALVRVLV LDTNDNSPFV LYPLQNGSAP CTELVPRAAE PGYLVTKVVA VDGDSGQNAW LSYQLLKATE PGLFGVWAHN GEVRTARLLS ERDAAKHRLV VLVKDNGEPP RSATATLHVL LVDGFSQPYL PLPEAAPAQA QADSLTVYLV VALASVSSLF LFSVLLFVAV RLCRRSRAAS VGRCSVPEGP FPGHLVDVSG TGTLSQSYQY EVCLTGDSGT GEFKFLKPIF PNLLVQDTGR EVKENPKFRN SLVFS