PCDB3_HUMAN » Protocadherin beta-3

PCDB3_HUMAN » Protocadherin beta-3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDB3_HUMAN » Protocadherin beta-3 » PCDH-beta-3;
Hydrophobic Thickness 37.6 ± 2.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -55.2 kcal/mol
ΔGfold -22.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 683-715 (680-717)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 1WYJ, Subunit A, Seq Identity:63%, Cadherin-like

AA: 138-233, PDBID: 4ZPL, Subunit A, Seq Identity:62%, Cadherin domain

AA: 247-338, PDBID: 4ZPL, Subunit A, Seq Identity:42%, Cadherin domain

AA: 353-442, PDBID: 4ZPL, Subunit A, Seq Identity:37%, Cadherin domain

AA: 456-552, PDBID: 4ZPL, Subunit A, Seq Identity:32%, Cadherin domain

AA: 575-663, PDBID: 3UBH, Subunit A, Seq Identity:33%, Cadherin domain

AA: 685-768, Cadherin cytoplasmic C-terminal

UniProt annotation for PCDB3_HUMAN » Protocadherin beta-3
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDB3_HUMAN » Protocadherin beta-3
SIGNAL 1 26 Potential.
CHAIN 27 796 Protocadherin beta-3.
DOMAIN 35 133 Cadherin 1.
DOMAIN 138 242 Cadherin 2.
DOMAIN 247 347 Cadherin 3.
DOMAIN 352 451 Cadherin 4.
DOMAIN 456 561 Cadherin 5.
DOMAIN 568 671 Cadherin 6.
Amino Acid Sequence for PCDB3_HUMAN » Protocadherin beta-3
MEAGGERFLR QRQVLLLFVF LGGSLAGSES RRYSVAEEKE KGFLIANLAK DLGLRVEELA ARGAQVVSKG NKQHFQLSHQ TGDLLLNEKL DREELCGPTE PCILHFQILL QNPLQFVTNE LRIIDVNDHS PVFFENEMHL KILESTLPGT VIPLGNAEDL DVGRNSLQNY TITPNSHFHV LTRSRRDGRK YPELVLDKAL DREEQPELSL TLTALDGGSP PRSGTAQINI QVLDINDNAP EFAQPLYEVA VLENTPVNSV IVTVSASDLD TGSFGTISYA FFHASEEIRK TFQLNPITGD MQLVKYLNFE AINSYEVDIE AKDGGGLSGK STVIVQVVDV NDNPPELTLS SVNSPIPENS GETVLAVFSV SDLDSGDNGR VMCSIENNLP FFLKPSVENF YTLVSEGALD RETRSEYNIT ITITDLGTPR LKTKYNITVL VSDVNDNAPA FTQISYTLFV RENNSPALHI GSVSATDRDS GTNAQVTYSL LPPQDPHLPL SSLVSINADN GHLFALRSLD YEALQAFEFR VGATDRGSPA LSSEALVRVL VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP PRSATATLHV LLVDGFSQPY LPLPEAAPAQ AQADLLTVYL VVALASVSSL FLFSVLLFVA VRLCRRSRAA SVGRCSVPEG PFPGQMVDVS GTGTLSQSYQ YEVCLTGGSG TNEFKFLKPI IPNFVAQGAE RVSEANPSFR KSFEFS