PCDB2_HUMAN » Protocadherin beta-2

PCDB2_HUMAN » Protocadherin beta-2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDB2_HUMAN » Protocadherin beta-2 » PCDH-beta-2;
Hydrophobic Thickness 38.0 ± 4.8 Å
Tilt Angle 40 ± 7°
ΔGtransfer -28.0 kcal/mol
ΔGfold -22.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 685-717 (682-719)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 32-114, PDBID: 1WYJ, Subunit A, Seq Identity:60%, Cadherin-like

AA: 140-235, PDBID: 4ZPL, Subunit A, Seq Identity:59%, Cadherin domain

AA: 249-340, PDBID: 4ZPL, Subunit A, Seq Identity:47%, Cadherin domain

AA: 356-444, PDBID: 4ZPL, Subunit A, Seq Identity:35%, Cadherin domain

AA: 458-554, PDBID: 2WCP, Subunit A, Seq Identity:31%, Cadherin domain

AA: 577-665, PDBID: 3UBH, Subunit A, Seq Identity:33%, Cadherin domain

AA: 687-770, Cadherin cytoplasmic C-terminal

UniProt annotation for PCDB2_HUMAN » Protocadherin beta-2
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDB2_HUMAN » Protocadherin beta-2
SIGNAL 1 30 Potential.
CHAIN 31 798 Protocadherin beta-2.
DOMAIN 37 135 Cadherin 1.
DOMAIN 136 244 Cadherin 2.
DOMAIN 249 349 Cadherin 3.
DOMAIN 354 453 Cadherin 4.
DOMAIN 458 563 Cadherin 5.
DOMAIN 570 673 Cadherin 6.
Amino Acid Sequence for PCDB2_HUMAN » Protocadherin beta-2
MEAGEGKERV PKQRQVLIFF VLLGIAQASC QPRHYSVAEE TESGSFVANL LKDLGLEIGE LAVRGARVVS KGKKMHLQFD RQTGDLLLNE KLDREELCGP TEPCVLPFQV LLENPLQFFQ AELRIRDVND HSPVFLDKEI LLKIPESITP GTTFLIERAQ DLDVGTNSLQ NYTISPNFHF HLNLQDSLDG IILPQLVLNR ALDREEQPEI RLTLTALDGG SPPRSGTALV RIEVVDINDN VPEFAKLLYE VQIPEDSPVG SQVAIVSARD LDIGTNGEIS YAFSQASEDI RKTFRLSAKS GELLLRQKLD FESIQTYTVN IQATDGGGLS GTCVVFVQVM DLNDNPPELT MSTLINQIPE NLQDTLIAVF SVSDPDSGDN GRMVCSIQDD LPFFLKPSVE NFYTLVISTA LDRETRSEYN ITITVTDFGT PRLKTEHNIT VLVSDVNDNA PAFTQTSYTL FVRENNSPAL HIGSVSATDR DSGTNAQVTY SLLPPQDPHL PLASLVSINA DNGHLFALQS LDYEALQAFE FRVGAADRGS PALSSEALVR VLVLDANDNS PFVLYPLQNG SAPCTELVPR AAEPGYLVTK VVAVDGDSGQ NAWLSYQLLK ATEPGLFGVW AHNGEVRTAR LLRERDAAKQ RLVVLVKDNG EPPRSATATL HVLLVDGFSQ PYLLLPEAAP AQAQADLLTV YLVVALASVS SLFLFSVLLF VAVRLCRRSR AASVGRCSVP EGPFPGQMVD VSGTGTLSQS YQYEVCLTGG SGTNEFKFLK PIIPNFVAQG AERVSEANPS FRKSFEFT