PCDB1_HUMAN » Protocadherin beta-1

PCDB1_HUMAN » Protocadherin beta-1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDB1_HUMAN » Protocadherin beta-1 » PCDH-beta-1;
Hydrophobic Thickness 38.0 ± 4.4 Å
Tilt Angle 18 ± 5°
ΔGtransfer -34.5 kcal/mol
ΔGfold -32.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 688-715 (686-722)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 4ZPL, Subunit A, Seq Identity:87%, Cadherin-like

AA: 138-233, PDBID: 4ZPL, Subunit A, Seq Identity:93%, Cadherin domain

AA: 247-338, PDBID: 4ZPL, Subunit A, Seq Identity:86%, Cadherin domain

AA: 353-443, PDBID: 4ZPL, Subunit A, Seq Identity:33%, Cadherin domain

AA: 457-553, PDBID: 4ZPL, Subunit A, Seq Identity:32%, Cadherin domain

AA: 577-664, PDBID: 4ZPN, Subunit B, Seq Identity:27%, Cadherin domain

AA: 686-772, Cadherin cytoplasmic C-terminal
UniProt annotation for PCDB1_HUMAN » Protocadherin beta-1
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDB1_HUMAN » Protocadherin beta-1
SIGNAL 1 28 Potential.
CHAIN 29 818 Protocadherin beta-1.
DOMAIN 35 133 Cadherin 1.
DOMAIN 138 242 Cadherin 2.
DOMAIN 243 347 Cadherin 3.
DOMAIN 348 452 Cadherin 4.
DOMAIN 457 562 Cadherin 5.
DOMAIN 577 672 Cadherin 6.
Amino Acid Sequence for PCDB1_HUMAN » Protocadherin beta-1
MAGTRRKSLQ NRQVGSLLIF LCISVGDATT IRYSVAEEME SGSFVANVAK DLGLEVGKLA ARGARLVSEG NKMHFRLHRK TGDLFVKEKL DRESLCGKAD PCVLHFEVVL VEPLQSFRAE VRVFDINDNA PVFLNKEPLL KIPESTPLGS RFPLQSAQDL DVGLNGLQNY TLSANGYFHL HTRFCSHGPK YAELVLNKPL DREEQPEVNL TITAVDGGSP PKSGTAHIHV VVLDVNDHVP QFSRLVYRAQ VSENSPNGSL VATVTAVDLD EGTNKAITYS LAQNPEAILK TFQIDPQNGE VRLRGPLDFE AIETYDIDIQ ATDGGGLSAH SKVLVEVVDV NDNPPEVMVS SVSSPLPEDS PPQTVVALFT IRDRDIRVGG KVTCFLREDL PFVIKPTFGN SYSLVTDRSL DREEVSGYNI TIVAMDTGPP SLSAETMIEV LISDVNDNPP IFREDSYILT VRENNSPAVF IGKVHAEDLD LGENAQITYS LLPPKNGDLS VFAYISINSG NGKLYALRTM DYEAIQDFQF VVKATDGGFL SLSSQVTVRV VVLDDNDNRP MILYPLQNGT LPCNDLVPRS AEAGYLVTKV VAVDGDSGQN SWLSYHLLKA TDLGLFSVQR QNGEIHTLRQ ISERDPMMQK LIILVQDHGQ PALSTTVSLN ILLVDGFSEP YLQFQDPTKH SRKVNPSTKY LVISLVILSF LFLLSVIVIF IIHVYQKIKY REKFTIQEHF YDDCNFSNNL VQGQGNGSLS RPCPYEMCSA TGTGNSEFRF LKRFMPNFPF PHATGEIKME AGSSLPPNSD RNKSQRLEGH DQVSDDYM