PCDAD_HUMAN » Protocadherin alpha-13

PCDAD_HUMAN » Protocadherin alpha-13
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDAD_HUMAN » Protocadherin alpha-13 » PCDH-alpha-13;
Hydrophobic Thickness 34.8 ± 2.0 Å
Tilt Angle 0 ± 1°
ΔGtransfer -41.2 kcal/mol
ΔGfold -21.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 699-721 (698-725)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 1WUZ, Subunit A, Seq Identity:94%, Cadherin-like

AA: 138-233, PDBID: 4ZPS, Subunit A, Seq Identity:47%, Cadherin domain

AA: 247-341, PDBID: 4ZPM, Subunit A, Seq Identity:46%, Cadherin domain

AA: 355-446, PDBID: 4ZPL, Subunit A, Seq Identity:37%, Cadherin domain

AA: 460-556, PDBID: 4ZPL, Subunit A, Seq Identity:30%, Cadherin domain

AA: 579-670, PDBID: 3UBH, Subunit A, Seq Identity:30%, Cadherin domain

AA: 800-933, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDAD_HUMAN » Protocadherin alpha-13
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDAD_HUMAN » Protocadherin alpha-13
SIGNAL 1 29 Potential.
CHAIN 30 950 Protocadherin alpha-13.
DOMAIN 34 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 350 Cadherin 3.
DOMAIN 351 455 Cadherin 4.
DOMAIN 456 565 Cadherin 5.
DOMAIN 581 678 Cadherin 6.
REPEAT 734 737 PXXP 1.
REPEAT 774 777 PXXP 2.
REPEAT 799 802 PXXP 3.
REPEAT 832 835 PXXP 4.
REPEAT 873 876 PXXP 5.
REPEAT 891 894 PXXP 6.
REGION 734 894 6 X 4 AA repeats of P-X-X-P.
Amino Acid Sequence for PCDAD_HUMAN » Protocadherin alpha-13
MLSSWQGGPR PRQLLLWLLI LAAWETGSGQ LHYSVPEEAK HGTFVGRIAQ DLGLELAELV PRLFRVASKR HGDLLEVNLQ NGILFVNSRI DREELCGRSA ECSIHLEVIV DRPLQVFHVE VKVRDINDNP PIFPESKKRI IIAESRPPET RFPLDGASDA DIGVNSALTY RLDPNDYFTL DAQNSLEQMS SLSLVLRKTL DREEIQEHSL LLTASDGGKP ELTGTVQLLI TILDVNDNAP EFYQSVYKVT VLENAFNGTL VIKLNATDPD DGTNGDIVYS FRRPVWPAVV YAFTINPNNG EIRTKGKLDF EEKKLYEISV EAVDKGNIPM AGHCTLLVEV LDVNDNAPEV TITSLSLPIR EDTQPSAIIA LISVSDRDSG SNGQVTCTLT PHVPFKLVST YKNYYSLVLD SALDRESVSA YELVVTARDG GSPSLWATAS VSVGVADVND NAPAFAQPEY TVFVKENNPP GCHIFTVSAQ DADAQENALV SYSLVERRVG ERALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVSARDS GVPPLGSNVT LQVFVLDEND NAPALLTPGA GSAGGTVSEL MPRSVGAGHV VAKVRAVDAD SGYNAWLSYE LQLAAVGARI PFRVGLYTGE ISTTRPLDEV DAPHHRLLVL VKDHGEPALT ATATVLLSLV ESGQAPQASS RASAGAVGPE AALVDVNVYL IIAICAVSSL LVLTLLLYTA LRCSAPPTEG ACAPGKPTLV CSSAAGSWSY SQQRRPRVCS GEGPHKTDLM AFSPSLPPCL GSAEGTGQRE EDSECLKEPR QPNPDWRYSA SLRAGMHSSV HLEEAGILRA GPGGPDQQWP TVSSATPEPE AGEVSPPVGA GVNSNSWTFK YGPGNPKQSG PGELPDKFII PGSPAIISIR QEPTNSQIDK SDFITFGKKE ETKKKKKKKK GNKTQEKKEK GNSTTDNSDQ