PCDAC_HUMAN » Protocadherin alpha-12

PCDAC_HUMAN » Protocadherin alpha-12
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDAC_HUMAN » Protocadherin alpha-12 » PCDH-alpha-12;
Hydrophobic Thickness 34.8 ± 2.0 Å
Tilt Angle 0 ± 1°
ΔGtransfer -41.2 kcal/mol
ΔGfold -21.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 699-721 (698-725)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 1WUZ, Subunit A, Seq Identity:91%, Cadherin-like

AA: 138-233, PDBID: 4ZI8, Subunit B, Seq Identity:44%, Cadherin domain

AA: 247-341, PDBID: 4ZPM, Subunit A, Seq Identity:47%, Cadherin domain

AA: 355-446, PDBID: 4ZPL, Subunit A, Seq Identity:35%, Cadherin domain

AA: 460-556, PDBID: 4ZPL, Subunit A, Seq Identity:30%, Cadherin domain

AA: 578-670, PDBID: 3UBH, Subunit A, Seq Identity:29%, Cadherin domain

AA: 791-924, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDAC_HUMAN » Protocadherin alpha-12
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDAC_HUMAN » Protocadherin alpha-12
SIGNAL 1 29 Potential.
CHAIN 30 941 Protocadherin alpha-12.
DOMAIN 30 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 350 Cadherin 3.
DOMAIN 351 455 Cadherin 4.
DOMAIN 456 565 Cadherin 5.
DOMAIN 581 678 Cadherin 6.
REPEAT 734 737 PXXP 1.
REPEAT 790 793 PXXP 2.
REPEAT 823 826 PXXP 3.
REPEAT 863 866 PXXP 4.
REPEAT 882 885 PXXP 5.
REGION 734 885 5 X 4 AA repeats of P-X-X-P.
Amino Acid Sequence for PCDAC_HUMAN » Protocadherin alpha-12
MVIIGPRGPG SQRLLLSLLL LAAWEVGSGQ LHYSVYEEAK HGTFVGRIAQ DLGLELAELV PRLFRVASKR HGDLLEVNLQ NGILFVNSRI DREKLCGRSA ECSIHLEVIV DRPLQVFHVD VEVKDINDNP PVFREREQKV PVSESAPLDS HFPLEGASDA DIGVNSLLTY ALSLNENFEL KIKTKKDKSI LPELVLRKLL DREQTPKLNL LLMVIDGGKP ELTGSVQIQI TVLDVNDNGP AFDKPSYKVV LSENVQNDTR VIQLNASDPD EGLNGEISYG IKMILPVSEK CMFSINPDTG EIRIYGELDF EENNAYEIQV NAIDKGIPSM AGHSMVLVEV LDVNDNVPEV MVTSLSLPVQ EDAQVGTVIA LISVSDRDSG ANGQVICSLT PHVPFKLVST YKNYYSLVLD SALDRESVSA YELVVTARDG GSPSLWATAR VSVEVADVND NAPAFAQPEY TVFVKENNPP GCHIFTVSAW DADAQKNALV SYSLVERRVG EHALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVSARDA GVPPLGSNVT LQVFVLDEND NAPALLATPA GSAGGAVSEL VPRSVGAGHV VAKVRAVDAD SGYNAWLSYE LQPAAVGAHI PFHVGLYTGE ISTTRILDEA DAPRHRLLVL VKDHGEPALT STATVLVSLV ENGQAPKTSS RASVGAVDPE AALVDINVYL IIAICAVSSL LVLTLLLYTA LRCSAPPTVS RCAPGKPTLV CSSAVGSWSY SQQRRQRVCS AESPPKTDLM AFSPSLQLSR EDCLNPPSEP RQPNPDWRYS ASLRAGMHSS VHLEEAGILR AGPGGPDQQW PTVSSATPEP EAGEVSPPVG AGVNSNSWTF KYGPGNPKQS GPGELPDKFI IPGSPAIISI RQEPTNSQID KSDFITFGKK EETKKKKKKK KGNKTQEKKE KGNSTTDNSD Q