PCDAB_HUMAN » Protocadherin alpha-11

PCDAB_HUMAN » Protocadherin alpha-11
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDAB_HUMAN » Protocadherin alpha-11 » PCDH-alpha-11;
Hydrophobic Thickness 38.4 ± 0.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -44.3 kcal/mol
ΔGfold -21.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 698-723 (697-725)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 1WUZ, Subunit A, Seq Identity:90%, Cadherin-like

AA: 139-233, PDBID: 4ZPL, Subunit A, Seq Identity:50%, Cadherin domain

AA: 247-340, PDBID: 4ZPM, Subunit A, Seq Identity:59%, Cadherin domain

AA: 354-445, PDBID: 4ZPL, Subunit A, Seq Identity:34%, Cadherin domain

AA: 459-555, PDBID: 4ZPL, Subunit A, Seq Identity:31%, Cadherin domain

AA: 580-669, PDBID: 3UBH, Subunit A, Seq Identity:30%, Cadherin domain

AA: 799-932, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDAB_HUMAN » Protocadherin alpha-11
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDAB_HUMAN » Protocadherin alpha-11
SIGNAL 1 29 Potential.
CHAIN 30 949 Protocadherin alpha-11.
DOMAIN 30 133 Cadherin 1.
DOMAIN 157 242 Cadherin 2.
DOMAIN 243 349 Cadherin 3.
DOMAIN 350 454 Cadherin 4.
DOMAIN 455 564 Cadherin 5.
DOMAIN 580 677 Cadherin 6.
REPEAT 733 736 PXXP 1.
REPEAT 773 776 PXXP 2.
REPEAT 795 798 PXXP 3.
REPEAT 831 834 PXXP 4.
REPEAT 872 875 PXXP 5.
REPEAT 890 893 PXXP 6.
REGION 733 893 6 X 4 AA repeats of P-X-X-P.
Amino Acid Sequence for PCDAB_HUMAN » Protocadherin alpha-11
MFGFQRRGLG TPRLQLWLLL LEFWEVGSGQ LHYSVSEEAK HGTFVGRIAQ DLGLELAELV QRLFRVASKT HGDLLEVNLQ NGILFVNSRI DREELCGQSA ECSIHLEVIV DRPLQVFHVN VEVKDINDNP PVFSLREQKL LIAESKQSDS RFPLEGASDA DIEENALLTY RLSKNEYFSL DSPTNGKQIK RLSLILKKSL DREKTPELNL LLTATDGGKP ELTGTVRLLV QVLDVNDNDP EFDKSEYKVS LMENAAKETL VLKLNATDRD EGVNGEVTYS LMSIKPNGRH LFTLDQNNGE VRVNGTLDYE ENKFYKIEVQ ATDKGTPPMA GHCTVWVEIL DTNDNSPEVA VTSLSLPVRE DAQPSTVIAL ISVSDRDSGV NGQVTCSLTP HVPFKLVSTF KNYYSLVLDS ALDRENVWAY ELVVTARDGG SPSLWATARV SVEVADVNDN APAFAQPEYT VFVKENNPPG CHIFTVSARD ADAQENALVS YSLVERRLGD RALSSYVSVH AESGKVYALQ PLDHEELELL QFQVSARDAG VPPLSSNVTL QVFVLDENDN APALLATQAG SAGGAVNKLV PRSVGAGHVV AKVRAVDADS GYNAWLSYEL QPAAGGSRIP FRVGLYTGEI STTRALDEAD SPRHRLLVLV KDHGEPALTA TATVLVSLVE SGQAPKASSR TLAGAASPEA ALVDVNVYLI IAICVVSSLL VLTLLLYTAL WWSATPTEGA CAPGKPTLVC SRAVGSWSYS QQRRQRVCSE EGPPKTDLMA FSPSLPLGLN KEEEGERQEP GSNHPGQPRQ PNPDWRYSAS LRAGMHSSVH LEEAGILRAG PGGPDQQWPT VSSATPEPEA GEVSPPVGAG VNSNSWTFKY GPGNPKQSGP GELPDKFIIP GSPAIISIRQ EPTNSQIDKS DFITFGKKEE TKKKKKKKKG NKTQEKKEKG NSTTDNSDQ