PCDAA_HUMAN » Protocadherin alpha-10

PCDAA_HUMAN » Protocadherin alpha-10
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDAA_HUMAN » Protocadherin alpha-10 » PCDH-alpha-10;
Hydrophobic Thickness 34.0 ± 1.6 Å
Tilt Angle 2 ± 2°
ΔGtransfer -42.0 kcal/mol
ΔGfold -21.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 696-719 (696-724)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 29-111, PDBID: 1WUZ, Subunit A, Seq Identity:89%, Cadherin-like

AA: 246-340, PDBID: 4ZPM, Subunit A, Seq Identity:47%, Cadherin domain

AA: 354-445, PDBID: 4ZPL, Subunit A, Seq Identity:36%, Cadherin domain

AA: 459-555, PDBID: 4ZPL, Subunit A, Seq Identity:31%, Cadherin domain

AA: 581-669, PDBID: 3UBH, Subunit A, Seq Identity:30%, Cadherin domain

AA: 798-931, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDAA_HUMAN » Protocadherin alpha-10
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDAA_HUMAN » Protocadherin alpha-10
SIGNAL 1 28 Potential.
CHAIN 29 948 Protocadherin alpha-10.
DOMAIN 29 132 Cadherin 1.
DOMAIN 133 241 Cadherin 2.
DOMAIN 242 349 Cadherin 3.
DOMAIN 350 454 Cadherin 4.
DOMAIN 455 564 Cadherin 5.
DOMAIN 587 689 Cadherin 6.
REPEAT 732 735 PXXP 1.
REPEAT 772 775 PXXP 2.
REPEAT 797 800 PXXP 3.
REPEAT 830 833 PXXP 4.
REPEAT 871 874 PXXP 5.
REPEAT 889 892 PXXP 6.
REGION 732 892 6 X 4 AA repeats of P-X-X-P.
Amino Acid Sequence for PCDAA_HUMAN » Protocadherin alpha-10
MVSRCSCLGV QCLLLSLLLL AAWEVGSGQL HYSVYEEARH GTFVGRIAQD LGLELAELVQ RLFRVASKRH GDLLEVNLQN GILFVNSRID REELCGRSVE CSIHLEVIVD RPLQVFHVDV EVKDINDNPP RFSVTEQKLS IPESRLLDSR FPLEGASDAD VGENALLTYK LSPNEYFVLD IINKKDKDKF PVLVLRKLLD REENPQLKLL LTATDGGKPE FTGSVSLLIL VLDANDNAPI FDRPVYEVKM YENQVNQTLV IRLNASDSDE GINKEMMYSF SSLVPPTIRR KFWINERTGE IKVNDAIDFE DSNTYEIHVD VTDKGNPPMV GHCTVLVELL DENDNSPEVI VTSLSLPVKE DAQVGTVIAL ISVSDHDSGA NGQVTCSLTP HVPFKLVSTY KNYYSLVLDS ALDRERVSAY ELVVTARDGG SPPLWATASV SVEVADVNDN APAFAQSEYT VFVKENNPPG CHIFTVSAWD ADAQENALVS YSLVERRLGE RSLSSYVSVH AESGKVYALQ PLDHEELELL QFQVSARDGG VPPLGSNLTL QVFVLDENDN APALLASPAG SAGGAVSELV LRSVVAGHVV AKVRAVDADS GYNAWLSYEL QSAAVGARIP FRVGLYTGEI STTRALDETD SPRQRLLVLV KDHGEPSLTA TATVLVSLVE GSQAPKASSR ASVGVAPEVA LVDVNVYLII AICAVSSLLV LTLLLYTALR CSAAPTEGAC GPVKPTLVCS SAVGSWSYSQ QRRQRVCSGE GLPKADLMAF SPSLPPCPMV DVDGEDQSIG GDHSRKPRQP NPDWRYSASL RAGMHSSVHL EEAGILRAGP GGPDQQWPTV SSATPEPEAG EVSPPVGAGV NSNSWTFKYG PGNPKQSGPG ELPDKFIIPG SPAIISIRQE PTNSQIDKSD FITFGKKEET KKKKKKKKGN KTQEKKEKGN STTDNSDQ