PCDA9_HUMAN » Protocadherin alpha-9

PCDA9_HUMAN » Protocadherin alpha-9
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDA9_HUMAN » Protocadherin alpha-9 » PCDH-alpha-9;
Hydrophobic Thickness 36.4 ± 1.6 Å
Tilt Angle 3 ± 2°
ΔGtransfer -40.3 kcal/mol
ΔGfold -21.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 699-721 (698-726)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 1WUZ, Subunit A, Seq Identity:90%, Cadherin-like

AA: 138-233, PDBID: 4ZI8, Subunit B, Seq Identity:47%, Cadherin domain

AA: 247-341, PDBID: 4ZPM, Subunit A, Seq Identity:46%, Cadherin domain

AA: 355-446, PDBID: 4ZPL, Subunit A, Seq Identity:34%, Cadherin domain

AA: 460-556, PDBID: 4ZPL, Subunit A, Seq Identity:30%, Cadherin domain

AA: 582-670, PDBID: 3UBH, Subunit A, Seq Identity:30%, Cadherin domain

AA: 695-773, Cadherin cytoplasmic C-terminal

AA: 800-933, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDA9_HUMAN » Protocadherin alpha-9
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDA9_HUMAN » Protocadherin alpha-9
SIGNAL 1 29 Potential.
CHAIN 30 950 Protocadherin alpha-9.
DOMAIN 30 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 350 Cadherin 3.
DOMAIN 351 455 Cadherin 4.
DOMAIN 456 565 Cadherin 5.
DOMAIN 588 678 Cadherin 6.
REPEAT 734 737 PXXP 1.
REPEAT 799 802 PXXP 2.
REPEAT 832 835 PXXP 3.
REPEAT 873 876 PXXP 4.
REPEAT 891 894 PXXP 5.
REGION 734 894 5 X 4 AA repeats of P-X-X-P.
Amino Acid Sequence for PCDA9_HUMAN » Protocadherin alpha-9
MLYSSRGDPE GQPLLLSLLI LAMWVVGSGQ LHYSVPEEAE HGTFVGRIAQ DLGLELAELV PRLFQLDSKG RGDLLEVNLQ NGILFVNSRI DREELCGRSA ECSIHLEVIV DRPLQVFHVD VEVKDINDNP PVFPATQKNL FIAESRPLDS RFPLEGASDA DIGENALLTY RLSPNEYFFL DVPTSNQQVK PLGLVLRKLL DREETPELHL LLTATDGGKP ELTGTVQLLI TVLDNNDNAP VFDRTLYTVK LPENVSIGTL VIHPNASDLD EGLNGDIIYS FSSDVSPDIK SKFHMDPLSG AITVIGHMDF EESRAHKIPV EAVDKGFPPL AGHCTLLVEV VDVNDNAPQL TIKTLSVPVK EDAQLGTVIA LISVIDLDAD ANGQVTCSLT PHVPFKLVST YKNYYSLVLD RALDRESVSA YELVVTARDG GSPSLWATAR VSVEVADVND NAPAFAQSEY TVFVKENNPP GCHIFTVSAR DADAQENALV SYSLVERRLG ERSLSSYVSV HAESGKVYAL QPLDHEELEL LQFQVSARDA GVPPLGSNVT LQVFVLDEND NAPALLTPRM RGTDGAVSEM VLRSVGAGVV VGKVRAVDAD SGYNAWLSYE LQPETASASI PFRVGLYTGE ISTTRALDET DAPRQRLLVL VKDHGEPALT ATATVLVSLV ESGQAPKSSS RASVGATGPE VTLVDVNVYL IIAICAVSSL LVLTLLLYTV LRCSAMPTEG ECAPGKPTLV CSSAVGSWSY SQQRRQRVCS GEGKQKTDLM AFSPGLSPCA GSTERTGEPS ASSDSTGKPR QPNPDWRYSA SLRAGMHSSV HLEEAGILRA GPGGPDQQWP TVSSATPEPE AGEVSPPVGA GVNSNSWTFK YGPGNPKQSG PGELPDKFII PGSPAIISIR QEPTNSQIDK SDFITFGKKE ETKKKKKKKK GNKTQEKKEK GNSTTDNSDQ