PCDA8_HUMAN » Protocadherin alpha-8

PCDA8_HUMAN » Protocadherin alpha-8
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDA8_HUMAN » Protocadherin alpha-8 » PCDH-alpha-8;
Hydrophobic Thickness 32.8 ± 1.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -39.4 kcal/mol
ΔGfold -20.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 699-721 (698-724)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 1WUZ, Subunit A, Seq Identity:91%, Cadherin-like

AA: 138-233, PDBID: 4ZI8, Subunit B, Seq Identity:47%, Cadherin domain

AA: 247-341, PDBID: 4ZPM, Subunit A, Seq Identity:52%, Cadherin domain

AA: 355-446, PDBID: 4ZPL, Subunit A, Seq Identity:36%, Cadherin domain

AA: 460-556, PDBID: 4ZPL, Subunit A, Seq Identity:30%, Cadherin domain

AA: 581-670, PDBID: 3UBH, Subunit A, Seq Identity:30%, Cadherin domain

AA: 800-933, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDA8_HUMAN » Protocadherin alpha-8
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDA8_HUMAN » Protocadherin alpha-8
SIGNAL 1 29 Potential.
CHAIN 30 950 Protocadherin alpha-8.
DOMAIN 30 133 Cadherin 1.
DOMAIN 157 242 Cadherin 2.
DOMAIN 243 350 Cadherin 3.
DOMAIN 351 455 Cadherin 4.
DOMAIN 456 565 Cadherin 5.
DOMAIN 581 678 Cadherin 6.
REPEAT 774 777 PXXP 1.
REPEAT 799 802 PXXP 2.
REPEAT 832 835 PXXP 3.
REPEAT 873 876 PXXP 4.
REPEAT 891 894 PXXP 5.
REGION 774 894 5 X 4 AA repeats of P-X-X-P.
Amino Acid Sequence for PCDA8_HUMAN » Protocadherin alpha-8
MDYHWRGELG SWRLLLLLLL LAAWKVGSGQ LHYSVPEEAK HGTFVGRIAQ DLGLELAELV PRLFRVASKR HRDLLEVSLQ NGILFVNSRI DREELCGRSA ECSIHLEVIV DRPLQVFHVD VEVKDVNDNP PVFRVKDQKL FVSESRMPDS RFPLEGASDA DVGANSVLTY RLSSHDYFML DVNSKNDENK LVELVLRKSL DREDAPAHHL FLTATDGGKP ELTGTVQLLV TVLDVNDNAP TFEQSEYEVR IFENADNGTT VIKLNASDPD EGANGAISYS FNSLVETMVI DHFSIDRNTG EIVIRGNLDF EQENLYKILI DATDKGHPPM AGHCTVLVRI LDKNDNVPEI ALTSLSLPVR EDAQFGTVIA LISVNDLDSG ANGQVTCSLM PHVPFKLVST FKNYYSLVLD SALDRERVSA YELVVTARDG GSPSLWATAS LSVEVADVND NAPAFAQPEY TVFVKENNPP GCHIFTVSAR DADAQENALV SYSLVERRVG ERSLSSYISV HTESGKVYAL QPLDHEELEL LQFQVSARDA GVPPLGSNVT LQVFVLDEND NAPALLEPRV GGTGGAASKL VPRSVGAGHV VAKVRAVDAD SGYNAWLSYE LQPAASSPRI PFRVGLYTGE ISTTRVLDEA DSPRHRLLVL VKDHGEPALT ATATVLVSLV ESGQAPKASS RQSAGVLGPE AALVDVNVYL IIAICAVSSL LVLTLLLYTA LRCSALPTEG GCRAGKPTLV CSSAVGSWSY SQQQPQRVCS GEGPPKTDLM AFSPCLPPDL GSVDVGEEQD LNVDHGLKPR QPNPDWRYSA SLRAGMHSSV HLEEAGILRA GPGGPDQQWP TVSSATPEPE AGEVSPPVGA GVNSNSWTFK YGPGNPKQSG PGELPDKFII PGSPAIISIR QEPTNSQIDK SDFITFGKKE ETKKKKKKKK GNKTQEKKEK GNSTTDNSDQ