PCDA7_HUMAN » Protocadherin alpha-7

PCDA7_HUMAN » Protocadherin alpha-7
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDA7_HUMAN » Protocadherin alpha-7 » PCDH-alpha-7;
Hydrophobic Thickness 34.8 ± 2.0 Å
Tilt Angle 0 ± 1°
ΔGtransfer -41.2 kcal/mol
ΔGfold -21.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 699-721 (698-725)
Pathways none
PDB none
OPM none
Complexes none
Interactions

A4, Complex: PCDA7:A4, PubMed

Domains

AA: 30-112, PDBID: 1WUZ, Subunit A, Seq Identity:89%, Cadherin-like

AA: 138-233, PDBID: 4ZI8, Subunit B, Seq Identity:47%, Cadherin domain

AA: 247-341, PDBID: 4ZPM, Subunit A, Seq Identity:47%, Cadherin domain

AA: 355-446, PDBID: 4ZPL, Subunit A, Seq Identity:37%, Cadherin domain

AA: 460-556, PDBID: 4ZPL, Subunit A, Seq Identity:30%, Cadherin domain

AA: 579-670, PDBID: 3UBH, Subunit A, Seq Identity:29%, Cadherin domain

AA: 695-773, Cadherin cytoplasmic C-terminal

AA: 787-920, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDA7_HUMAN » Protocadherin alpha-7
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDA7_HUMAN » Protocadherin alpha-7
SIGNAL 1 29 Potential.
CHAIN 30 937 Protocadherin alpha-7.
DOMAIN 30 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 350 Cadherin 3.
DOMAIN 351 455 Cadherin 4.
DOMAIN 456 565 Cadherin 5.
DOMAIN 581 678 Cadherin 6.
REPEAT 774 777 PXXP 1.
REPEAT 786 789 PXXP 2.
REPEAT 819 822 PXXP 3.
REPEAT 860 863 PXXP 4.
REPEAT 878 881 PXXP 5.
REGION 774 881 5 X 4 AA repeats of P-X-X-P.
Amino Acid Sequence for PCDA7_HUMAN » Protocadherin alpha-7
MVCPNGYDPG GRHLLLFIII LAAWEAGRGQ LHYSVPEEAK HGNFVGRIAQ DLGLELAELV PRLFRAVCKF RGDLLEVNLQ NGILFVNSRI DREELCGRSA ECSIHLEVIV ERPLQVFHVD VEVKDINDNP PVFPATQRNL FIAESRPLDS RFPLEGASDA DIGENALLTY RLSPNEYFFL DVPTSNQQVK PLGLVLRKLL DREETPELHL LLTATDGGKP ELTGTVQLLI TVLDNNDNAP VFDRTLYTVK LPENVSIGTL VIHPNASDLD EGLNGDIIYS FSSDVSPDIK SKFHMDPLSG AITVIGHMDF EESRAHKIPV EAVDKGFPPL AGHCTVLVEV VDVNDNAPQL TLTSLSLPIP EDAQPGTVIT LISVFDRDFG VNGQVTCSLT PRVPFKLVST FKNYYSLVLD SALDRESVSA YELVVTARDG GSPSLWATAS VSVEVADVND NAPAFAQPEY TVFVKENNPP GCHIFTVSAG DADAQKNALV SYSLVELRVG ERALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVSARDA GVPPLGSNVT LQVFVLDEND NAPALLAPRV GGTGGAVREL VPRSVGAGHV VAKVRAVDAD SGYNAWLSYE LQPVAAGASI PFRVGLYTGE ISTTRALDET DAPRHRLLVL VKDHGEPSLT ATATVLVSLV ESGQAPKASS RASLGIAGPE TELVDVNVYL IIAICAVSSL LVLTLLLYTA LRCSAPSSEG ACSLVKPTLV CSSAVGSWSF SQQRRQRVCS GEGPPKTDLM AFSPSLPQGP SSTDNPRQPN PDWRYSASLR AGMHSSVHLE EAGILRAGPG GPDQQWPTVS SATPEPEAGE VSPPVGAGVN SNSWTFKYGP GNPKQSGPGE LPDKFIIPGS PAIISIRQEP TNSQIDKSDF ITFGKKEETK KKKKKKKGNK TQEKKEKGNS TTDNSDQ