PCDA6_HUMAN » Protocadherin alpha-6

PCDA6_HUMAN » Protocadherin alpha-6
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDA6_HUMAN » Protocadherin alpha-6 » PCDH-alpha-6;
Hydrophobic Thickness 34.8 ± 2.0 Å
Tilt Angle 0 ± 1°
ΔGtransfer -41.2 kcal/mol
ΔGfold -21.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 699-721 (698-725)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 1WUZ, Subunit A, Seq Identity:94%, Cadherin-like

AA: 138-233, PDBID: 4ZI8, Subunit B, Seq Identity:38%, Cadherin domain

AA: 247-341, PDBID: 4ZPM, Subunit A, Seq Identity:50%, Cadherin domain

AA: 355-446, PDBID: 4ZPL, Subunit A, Seq Identity:37%, Cadherin domain

AA: 460-556, PDBID: 4ZPL, Subunit A, Seq Identity:30%, Cadherin domain

AA: 578-670, PDBID: 3UBH, Subunit A, Seq Identity:29%, Cadherin domain

AA: 800-933, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDA6_HUMAN » Protocadherin alpha-6
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDA6_HUMAN » Protocadherin alpha-6
SIGNAL 1 29 Potential.
CHAIN 30 950 Protocadherin alpha-6.
DOMAIN 34 133 Cadherin 1.
DOMAIN 157 242 Cadherin 2.
DOMAIN 243 350 Cadherin 3.
DOMAIN 351 455 Cadherin 4.
DOMAIN 456 565 Cadherin 5.
DOMAIN 581 678 Cadherin 6.
REPEAT 799 802 PXXP 1.
REPEAT 832 835 PXXP 2.
REPEAT 873 876 PXXP 3.
REPEAT 891 894 PXXP 4.
REGION 799 894 4 X 4 AA repeats of P-X-X-P.
Amino Acid Sequence for PCDA6_HUMAN » Protocadherin alpha-6
MVFTPEDRLG KQCLLLPLLL LAAWKVGSGQ LHYSVPEEAK HGTFVGRIAQ DLGLELAELV PRLFRMASKD REDLLEVNLQ NGILFVNSRI DREELCGRSA ECSIHLEVIV DRPLQVFHVD VEVRDINDNP PLFPVEEQRV LIYESRLPDS VFPLEGASDA DVGSNSILTY KLSSSEYFGL DVKINSDDNK QIGLLLKKSL DREEAPAHNL FLTATDGGKP ELTGTVQLLV TVLDVNDNAP TFEQSEYEVR IFENADNGTT VIRLNASDRD EGANGAISYS FNSLVAAMVI DHFSIDRNTG EIVIRGNLDF EQENLYKILI DATDKGHPPM AGHCTVLVRI LDKNDNVPEI ALTSLSLPVR EDAQFGTVIA LISVNDLDSG ANGQVNCSLT PHVPFKLVST FKNYYSLVLD SALDRESVSA YELVVTARDG GSPSLWATAS LSVEVADMND NAPAFAQPEY TVFVKENNPP GCHIFTVSAR DADAQENALV SYSLVERRVG ERALSSYISV HAESGKVYAL QPLDHEELEL LQFQVSARDA GVPPLGSNVT LQVFVLDEND NAPALLAPRV GGTGGAVSEL VPRSLGAGQV VAKVRAVDAD SGYNAWLSYE LQPPASSARF PFRVGLYTGE ISTTRVLDEA DSPRHRLLVL VKDHGEPALT ATATVLVSLV ESGQAPKASS RASVGAAGPE AALVDVNVYL IIAICAVSSL LVLTLLLYTA LRCSAPPTEG ACTADKPTLV CSSAVGSWSY SQQRRQRVCS GEGPPKMDLM AFSPSLSPCP IMMGKAENQD LNEDHDAKPR QPNPDWRYSA SLRAGMHSSV HLEEAGILRA GPGGPDQQWP TVSSATPEPE AGEVSPPVGA GVNSNSWTFK YGPGNPKQSG PGELPDKFII PGSPAIISIR QEPTNSQIDK SDFITFGKKE ETKKKKKKKK GNKTQEKKEK GNSTTDNSDQ