PCDA5_HUMAN » Protocadherin alpha-5

PCDA5_HUMAN » Protocadherin alpha-5
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDA5_HUMAN » Protocadherin alpha-5 » PCDH-alpha-5;
Hydrophobic Thickness 34.0 ± 1.6 Å
Tilt Angle 2 ± 2°
ΔGtransfer -42.0 kcal/mol
ΔGfold -21.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 697-720 (697-725)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 29-111, PDBID: 1WUZ, Subunit A, Seq Identity:94%, Cadherin-like

AA: 137-232, PDBID: 4ZPM, Subunit A, Seq Identity:38%, Cadherin domain

AA: 246-340, PDBID: 4ZPM, Subunit A, Seq Identity:51%, Cadherin domain

AA: 356-445, PDBID: 4ZPL, Subunit A, Seq Identity:36%, Cadherin domain

AA: 459-555, PDBID: 2YST, Subunit A, Seq Identity:30%, Cadherin domain

AA: 577-669, PDBID: 3UBH, Subunit A, Seq Identity:30%, Cadherin domain

AA: 786-919, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDA5_HUMAN » Protocadherin alpha-5
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDA5_HUMAN » Protocadherin alpha-5
SIGNAL 1 28 Potential.
CHAIN 29 936 Protocadherin alpha-5.
DOMAIN 33 132 Cadherin 1.
DOMAIN 156 241 Cadherin 2.
DOMAIN 242 349 Cadherin 3.
DOMAIN 350 454 Cadherin 4.
DOMAIN 455 564 Cadherin 5.
DOMAIN 580 677 Cadherin 6.
REPEAT 773 776 PXXP 1.
REPEAT 785 788 PXXP 2.
REPEAT 818 821 PXXP 3.
REPEAT 873 876 PXXP 4.
REPEAT 877 890 PXXP 5.
REGION 773 890 5 X 4 AA repeats of P-X-X-P.
Amino Acid Sequence for PCDA5_HUMAN » Protocadherin alpha-5
MVYSRRGSLG SRLLLLWLLL AYWKAGSGQL HYSIPEEAKH GTFVGRIAQD LGLELAELVP RLFRVASKGR GDLLEVNLQN GILFVNSRID REELCRRRAE CSIHLEVIVD RPLQVFHVEV AVKDINDNPP RFSRQEQRLF ILESRMPDSR FPLEGASDLD IGANAQLRYR LNPNEYFDLD VKTNEEETNF LELVLRKSLD REETQEHRLL VIATDGGKPE LTGTVQLLIN VLDANDNAPE FDKSIYNVRL LENAPSGTLV IKLNASDADE GINKEIVYFF SNLVLDDVKS KFIINSNTGE IKVNGELDYE DYNSYEINID AMDKSTFPLS GHCKVVVKLL DVNDNTPEMA ITTLFLPVKE DAPLSTVIAL ISVSDRDSGA NGQVTCSLMP HVPFKLVSTF KNYYSLVLDS ALDRESVSVY ELVVTARDGG SPSLWATASV SVEVADVNDN APAFAQPQYT VFVKENNPPG CHIFTVSARD ADAQENALVS YSLVERRVGE RPLSSYVSVH AESGKVYALQ PLDHEEVELL QFQVSARDAG VPPLGSNVTL QVFVLDENDN APALLVPRVG GTGGAVSELV PRSVGAGHVV AKVRAVDPDS GYNAWLSYEL QPAPGSARIP FRVGLYTGEI STTRSLDETE APRHRLLVLV KDHGEPPLTA TATVLVSLVE SGQAPKASSR ASAGAVGPEA ALVDVNVYLI IAICAVSSLL VLTLLLYTAL RCSAQPTEAV CTRGKPTLLC SSAVGSWSYS QQRRQRVCSG EAPPKTDLMA FSPSLPQGPT STDNPRQPNP DWRYSASLRA GMHSSVHLEE AGILRAGPGG PDQQWPTVSS ATPEPEAGEV SPPVGAGVNS NSWTFKYGPG NPKQSGPGEL PDKFIIPGSP AIISIRQEPT NSQIDKSDFI TFGKKEETKK KKKKKKGNKT QEKKEKGNST TDNSDQ