PCDA4_HUMAN » Protocadherin alpha-4

PCDA4_HUMAN » Protocadherin alpha-4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDA4_HUMAN » Protocadherin alpha-4 » PCDH-alpha-4;
Hydrophobic Thickness 32.8 ± 1.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -39.4 kcal/mol
ΔGfold -20.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 699-721 (698-724)
Pathways none
PDB none
OPM none
Complexes none
Interactions

APLP1, Complex: APLP1:PCDA4, PubMed

CC90B, Complex: PCDA4:CC90B, PubMed

Domains

AA: 30-112, PDBID: 1WUZ, Subunit A, Seq Identity:91%, Cadherin-like

AA: 138-233, PDBID: 4ZPM, Subunit A, Seq Identity:49%, Cadherin domain

AA: 247-341, PDBID: 4ZPM, Subunit A, Seq Identity:50%, Cadherin domain

AA: 355-446, PDBID: 4ZPL, Subunit A, Seq Identity:39%, Cadherin domain

AA: 460-556, PDBID: 4ZPL, Subunit A, Seq Identity:30%, Cadherin domain

AA: 577-670, PDBID: 3UBH, Subunit A, Seq Identity:29%, Cadherin domain

AA: 797-930, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDA4_HUMAN » Protocadherin alpha-4
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

SUBUNIT: Interacts with FYN.

UniProt features for PCDA4_HUMAN » Protocadherin alpha-4
SIGNAL 1 29 Potential.
CHAIN 30 947 Protocadherin alpha-4.
DOMAIN 30 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 350 Cadherin 3.
DOMAIN 351 455 Cadherin 4.
DOMAIN 456 565 Cadherin 5.
DOMAIN 588 678 Cadherin 6.
REPEAT 734 737 PXXP 1.
REPEAT 774 777 PXXP 2.
REPEAT 796 799 PXXP 3.
REPEAT 829 832 PXXP 4.
REPEAT 870 873 PXXP 5.
REPEAT 888 891 PXXP 6.
REGION 734 891 6 X 4 AA repeats of P-X-X-P.
Amino Acid Sequence for PCDA4_HUMAN » Protocadherin alpha-4
MEFSWGSGQE SRRLLLLLLL LAAWEAGNGQ LHYSVSEEAK HGTFVGRIAQ DLGLELAELV PRLFRVASKG RGGLLEVNLQ NGILFVNSRI DREELCRRSA ECSIHLEVIV DRPLQVFHVD VEVRDINDNP PVFPATQKNL SIAESRPLDS RFPLEGASDA DIGENALLTY RLSPNEYFSL EKPPDDELVK GLGLILRKSL DREEAPEIFL VLTATDGGKP ELTGTVQLLI TVLDANDNAP AFDRTIYKVR LLENVPNGTL VIKLNASDLD EGLNGDIVYS FSNDISPNVK SKFHIDPITG QIIVKGYIDF EESKSYEIIV EGIDKGQLPL SGHCRVIVEV EDNNDNVPDL EFKSLSLPIR EDAPLGTVIA LISVSDKDMG VNGLVTCSLT SHVPFKLVST FKNYYSLVLD SALDRESVSA YELVVTARDG GSPSLWATAS VSVEVADVND NAPAFAQPEY TVFVKENNPP GCHIFTVSAW DADAQENALV SYSLVERRVG ERALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVTARDA GVPPLGSNVT LQVFVLDEND NAPALLAPRA GGTGGAVSEL VPWSVGVGHV VAKVRAVDAD SGYNAWLSYE LQPGTGGARI PFRVGLYTGE ISTTRALDET DAPRHRLLVL VKDHGEPALT ATATVLVSLV ESGQAPKASS RALVGAVGPD AALVDVNVYL IIAICAVSSL LVLTLLLYTA LRCSALPTEG ACAPGKPTLV CSSAVGSWSY SQQRRPRVCS GEGPPKTDLM AFSPSLPDSR DREDQLQTTE ESFAKPRQPN PDWRYSASLR AGMHSSVHLE EAGILRAGPG GPDQQWPTVS SATPEPEAGE VSPPVGAGVN SNSWTFKYGP GNPKQSGPGE LPDKFIIPGS PAIISIRQEP TNSQIDKSDF ITFGKKEETK KKKKKKKGNK TQEKKEKGNS TTDNSDQ