PCDA3_HUMAN » Protocadherin alpha-3

PCDA3_HUMAN » Protocadherin alpha-3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDA3_HUMAN » Protocadherin alpha-3 » PCDH-alpha-3;
Hydrophobic Thickness 34.4 ± 1.8 Å
Tilt Angle 1 ± 2°
ΔGtransfer -42.4 kcal/mol
ΔGfold -20.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 698-721 (698-725)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 1WUZ, Subunit A, Seq Identity:92%, Cadherin-like

AA: 138-233, PDBID: 4ZPM, Subunit A, Seq Identity:50%, Cadherin domain

AA: 247-341, PDBID: 4ZI8, Subunit B, Seq Identity:50%, Cadherin domain

AA: 356-446, PDBID: 4ZPL, Subunit A, Seq Identity:37%, Cadherin domain

AA: 460-556, PDBID: 4ZPL, Subunit A, Seq Identity:30%, Cadherin domain

AA: 578-670, PDBID: 3PPE, Subunit A, Seq Identity:29%, Cadherin domain

AA: 800-933, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDA3_HUMAN » Protocadherin alpha-3
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDA3_HUMAN » Protocadherin alpha-3
SIGNAL 1 29 Potential.
CHAIN 30 950 Protocadherin alpha-3.
DOMAIN 30 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 350 Cadherin 3.
DOMAIN 351 455 Cadherin 4.
DOMAIN 456 565 Cadherin 5.
DOMAIN 581 678 Cadherin 6.
REPEAT 734 737 PXXP 1.
REPEAT 774 777 PXXP 2.
REPEAT 799 802 PXXP 3.
REPEAT 832 835 PXXP 4.
REPEAT 873 876 PXXP 5.
REPEAT 891 894 PXXP 6.
REGION 734 894 6 X 4 AA repeats of P-X-X-P.
Amino Acid Sequence for PCDA3_HUMAN » Protocadherin alpha-3
MLFSWREDPG AQCLLLSLLL LAASEVGSGQ LHYSVSEEAK HGTFVGRIAQ DLGLELAELV PRLFRVASKR HGDLLEVNLQ NGILFVNSRI DREELCGRSA ECSIHLEVIV DRPLQVFHVE VEVKDINDNA PVFPMAVKNL FISESRQPGS RFSLEGASDA DIGTNSLLTY SLDSTEYFTL DVKRNDEEIK SLGLVLKKNL NREDTPKHYL LITAIDGGKP ELTGTTQLKI TVLDVNDNAP AFERTIYKVR LLENAPNGTL VVTVNATDLD EGVNKDIAYS FNTDMSADIL SKFHLDPVNG QISVKGNIDF EESKSYEIQV EATDKGNPPM SDHCTVLLEI VDINDNVPEL VIQSLSLPVL EDSPLSTVIA LISVSDRDSG VNGQVTCSLT PHVPFKLVST FKNYYSLVLD SPLDRESVSA YELVVTARDG GSPSLWATAS VSVEVADVND NAPAFSQSEY TVFVKENNPP GCHIFTVSAR DADAQENALV SYSLVERRVG ERALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVSARDA GVPPLGSNVT LQVFVLDEND NAPALLMPRV GGIGGAVSEL VPRSVGAGHV VAKVRAVDAD SGYNAWLSYE LQPGTGGARI PFRVGLYTGE ISTTRALDEV DAPRHRLLVL VKDHGEPSLT ATATVLVSLV ESGQAPKASS QASAGATGPE AALVDVNVYL IVAICAVSSL LVLTLLLYTA LRCSAPPTEG DCGPGKPTLV CSSAVGSWSY SQQRQQRVCS GEGLPKTDLM AFSPSLPPCP ISRDREEKQD VDVDLSAKPR QPNPDWRYSA SLRAGMHSSV HLEEAGILRA GPGGPDQQWP TVSSATPEPE AGEVSPPVGA GVNSNSWTFK YGPGNPKQSG PGELPDKFII PGSPAIISIR QEPTNSQIDK SDFITFGKKE ETKKKKKKKK GNKTQEKKEK GNSTTDNSDQ