PCDA2_HUMAN » Protocadherin alpha-2

PCDA2_HUMAN » Protocadherin alpha-2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDA2_HUMAN » Protocadherin alpha-2 » PCDH-alpha-2;
Hydrophobic Thickness 33.2 ± 2.0 Å
Tilt Angle 2 ± 1°
ΔGtransfer -35.0 kcal/mol
ΔGfold -20.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 699-721 (698-724)
Pathways none
PDB none
OPM none
Complexes none
Interactions

NICA, Complex: NICA:PCDA2, PubMed

Domains

AA: 30-112, PDBID: 1WUZ, Subunit A, Seq Identity:91%, Cadherin-like

AA: 138-233, PDBID: 4ZPM, Subunit A, Seq Identity:48%, Cadherin domain

AA: 247-341, PDBID: 4ZPM, Subunit A, Seq Identity:53%, Cadherin domain

AA: 355-446, PDBID: 4ZI8, Subunit B, Seq Identity:35%, Cadherin domain

AA: 460-556, PDBID: 2YST, Subunit A, Seq Identity:30%, Cadherin domain

AA: 577-670, PDBID: 3UBH, Subunit A, Seq Identity:29%, Cadherin domain

AA: 798-931, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDA2_HUMAN » Protocadherin alpha-2
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDA2_HUMAN » Protocadherin alpha-2
SIGNAL 1 22
CHAIN 23 948 Protocadherin alpha-2.
DOMAIN 30 133 Cadherin 1.
DOMAIN 157 242 Cadherin 2.
DOMAIN 243 350 Cadherin 3.
DOMAIN 351 455 Cadherin 4.
DOMAIN 456 565 Cadherin 5.
DOMAIN 588 678 Cadherin 6.
REPEAT 734 737 PXXP 1.
REPEAT 797 800 PXXP 2.
REPEAT 830 833 PXXP 3.
REPEAT 871 874 PXXP 4.
REPEAT 889 892 PXXP 5.
REGION 734 892 5 X 4 AA repeats of P-X-X-P.
Amino Acid Sequence for PCDA2_HUMAN » Protocadherin alpha-2
MASSIRRGRG AWTRLLSLLL LAAWEVGSGQ LRYSVPEEAK HGTFVGRIAQ DLGLELEELV PRLFRVASKR HGDLLEVNLQ NGILFVNSRI DREELCGRSA ECSIHVEVIV DRPLQVFHVE VEVKDINDNP PIFPMTVKTI RFPESRLLDS RFPLEGASDA DIGVNALLSY KLSSSEFFFL DIQANDELSE SLSLVLGKSL DREETAEVNL LLVATDGGKP ELTGTVQILI KVLDVNDNEP TFAQSVYKVK LLENTANGTL VVKLNASDAD EGPNSEIVYS LGSDVSSTIQ TKFTIDPISG EIRTKGKLDY EEAKSYEIQV TATDKGTPSM SGHCKISLKL VDINDNTPEV SITSLSLPIS ENASLGTVIA LITVSDRDSG TNGHVTCSLT PHVPFKLVST FKNYYSLVLD SALDRESVSA YELVVTARDG GSPSLWATTS VSIEVADVND NAPAFAQPEY TVFVKENNPP GCHIFTVSAW DADAQENALV SYSLVERRVG ERALSSYVSV HAESGKVYAL QPLDHEEVEL LQFQVSARDA GVPPLGSNVT LQVFVLDEND NAPALLAPRA GTAAGAVSEL VPWSVGAGHV VAKVRAVDAD SGYNAWLSYE LQLGTGSARI PFRVGLYTGE ISTTRALDEA DSPRHRLLVL VKDHGEPALT ATATVLVSLV ESGQAPKASS RAWVGAAGSE ATLVDVNVYL IIAICAVSSL LVLTVLLYTA LRCSVPPTEG ARAPGKPTLV CSSAVGSWSY SQQRRQRVCS GEDPPKTDLM AFSPSLSQGP DSAEEKQLSE SEYVGKPRQP NPDWRYSASL RAGMHSSVHL EEAGILRAGP GGPDQQWPTV SSATPEPEAG EVSPPVGAGV NSNSWTFKYG PGNPKQSGPG ELPDKFIIPG SPAIISIRQE PTNSQIDKSD FITFGKKEET KKKKKKKKGN KTQEKKEKGN STTDNSDQ