PCDA1_HUMAN » Protocadherin alpha-1

PCDA1_HUMAN » Protocadherin alpha-1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDA1_HUMAN » Protocadherin alpha-1 » PCDH-alpha-1;
Hydrophobic Thickness 32.8 ± 1.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -39.4 kcal/mol
ΔGfold -20.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 699-721 (698-724)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-112, PDBID: 1WUZ, Subunit A, Seq Identity:88%, Cadherin-like

AA: 138-233, PDBID: 4ZPM, Subunit A, Seq Identity:49%, Cadherin domain

AA: 247-341, PDBID: 4ZPM, Subunit A, Seq Identity:51%, Cadherin domain

AA: 356-446, PDBID: 4ZPL, Subunit A, Seq Identity:36%, Cadherin domain

AA: 460-556, PDBID: 4ZPL, Subunit A, Seq Identity:30%, Cadherin domain

AA: 578-670, PDBID: 3UBH, Subunit A, Seq Identity:30%, Cadherin domain

AA: 800-933, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDA1_HUMAN » Protocadherin alpha-1
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDA1_HUMAN » Protocadherin alpha-1
SIGNAL 1 29 Potential.
CHAIN 30 950 Protocadherin alpha-1.
DOMAIN 30 133 Cadherin 1.
DOMAIN 157 242 Cadherin 2.
DOMAIN 243 350 Cadherin 3.
DOMAIN 351 455 Cadherin 4.
DOMAIN 456 565 Cadherin 5.
DOMAIN 588 678 Cadherin 6.
REPEAT 734 737 PXXP 1.
REPEAT 799 802 PXXP 2.
REPEAT 832 835 PXXP 3.
REPEAT 873 876 PXXP 4.
REPEAT 891 894 PXXP 5.
REGION 734 894 5 X 4 AA repeats of P-X-X-P.
Amino Acid Sequence for PCDA1_HUMAN » Protocadherin alpha-1
MVFSRRGGLG ARDLLLWLLL LAAWEVGSGQ LHYSIPEEAK HGTFVGRVAQ DLGLELAELV PRLFRVASKT HRDLLEVNLQ NGILFVNSRI DREELCQWSA ECSIHLELIA DRPLQVFHVE VKVKDINDNP PVFRGREQII FIPESRLLNS RFPIEGAADA DIGANALLTY TLSPSDYFSL DVEASDELSK SLWLELRKYL DREETPELHL LLTATDGGKP ELQGTVELLI TVLDVNDNAP LFDQAVYRVH LLETTANGTL VTTLNASDAD EGVNGEVVFS FDSGISRDIQ EKFKVDSSSG EIRLIDKLDY EETKSYEIQV KAVDKGSPPM SNHCKVLVKV LDVNDNAPEL AVTSLYLPIR EDAPLSTVIA LITVSDRDSG ANGQVTCSLM PHVPFKLVST FKNYYSLVLD SALDRESLSV YELVVTARDG GSPSLWATAR VSVEVADVND NAPAFAQPEY TVFVKENNPP GCHIFTVSAR DADAQENALV SYSLVERRVG ERALSNYVSV HAESGKVYAL QPLDHEELEL LQFQVSARDA GVPPLGSNVT LQVFVLDEND NAPALLAPRV GGTIGAVSEL VPRLVGAGHV VAKVRAVDAD SGYNAWLSYE LQPAAGGARI PFRVGLYTGE ISTTRVLDEA DLSRYRLLVL VKDHGEPALT ATATVLVSLV ESGQAPKASS RASVGVAGPE AALVDVNVYL IIAICAVSSL LVLTLLLYTA LRCSVPPTEG AYVPGKPTLV CSSALGSWSN SQQRRQRVCS SEGPPKTDLM AFSPGLSPSL NTSERNEQPE ANLDLSGNPR QPNPDWRYSA SLRAGMHSSV HLEEAGILRA GPGGPDQQWP TVSSATPEPE AGEVSPPVGA GVNSNSWTFK YGPGNPKQSG PGELPDKFII PGSPAIISIR QEPTNSQIDK SDFITFGKKE ETKKKKKKKK GNKTQEKKEK GNSTTDNSDQ