PCD23_HUMAN » Protocadherin-23

PCD23_HUMAN » Protocadherin-23
Magnify PCD23_HUMAN » Protocadherin-23Enlarged view of image
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCD23_HUMAN » Protocadherin-23 » Cadherin-27;Cadherin-like protein CDHJ;Cadherin-like protein VR8;Protein dachsous homolog 2;Protocadherin PCDHJ;
Hydrophobic Thickness 34.8 ± 4.0 Å
Tilt Angle 21 ± 4°
ΔGtransfer -32.6 kcal/mol
ΔGfold -27.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 2539-2564 (2536-2567)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 63-154, PDBID: 3UBH, Subunit A, Seq Identity:28%, Cadherin domain

AA: 382-471, PDBID: 2A62, Subunit A, Seq Identity:33%, Cadherin domain

AA: 485-575, PDBID: 2WCP, Subunit A, Seq Identity:34%, Cadherin domain

AA: 590-683, PDBID: 2WBX, Subunit A, Seq Identity:27%, Cadherin domain

AA: 848-939, PDBID: 4ZPM, Subunit A, Seq Identity:40%, Cadherin domain

AA: 953-1046, PDBID: 2WCP, Subunit A, Seq Identity:29%, Cadherin domain

AA: 1060-1156, PDBID: 3UBF, Subunit A, Seq Identity:33%, Cadherin domain

AA: 1169-1260, PDBID: 4ZPL, Subunit A, Seq Identity:36%, Cadherin domain

AA: 1274-1365, PDBID: 2O72, Subunit A, Seq Identity:33%, Cadherin domain

AA: 1379-1469, PDBID: 3PPE, Subunit A, Seq Identity:33%, Cadherin domain

AA: 1483-1574, PDBID: 4ZPM, Subunit A, Seq Identity:32%, Cadherin domain

AA: 1589-1676, PDBID: 2WCP, Subunit A, Seq Identity:30%, Cadherin domain

AA: 1689-1778, PDBID: 4ZPS, Subunit A, Seq Identity:28%, Cadherin domain

AA: 1792-1883, PDBID: 4ZI8, Subunit B, Seq Identity:41%, Cadherin domain

AA: 1896-1983, PDBID: 2WBX, Subunit A, Seq Identity:31%, Cadherin domain

AA: 1997-2085, PDBID: 2WCP, Subunit A, Seq Identity:31%, Cadherin domain

AA: 2099-2201, PDBID: 4ZPM, Subunit A, Seq Identity:34%, Cadherin domain

AA: 2215-2305, PDBID: 2A62, Subunit A, Seq Identity:32%, Cadherin domain

AA: 2319-2416, PDBID: 4ZI9, Subunit B, Seq Identity:31%, Cadherin domain

UniProt annotation for PCD23_HUMAN » Protocadherin-23
FUNCTION: Calcium-dependent cell-adhesion protein.

TISSUE SPECIFICITY: Cerebral cortex and testis.

UniProt features for PCD23_HUMAN » Protocadherin-23
CHAIN 1 2916 Protocadherin-23.
DOMAIN 56 177 Cadherin 1.
DOMAIN 178 382 Cadherin 2.
DOMAIN 378 480 Cadherin 3.
DOMAIN 481 583 Cadherin 4.
DOMAIN 586 692 Cadherin 5.
DOMAIN 693 839 Cadherin 6.
DOMAIN 844 960 Cadherin 7.
DOMAIN 949 1055 Cadherin 8.
DOMAIN 1056 1165 Cadherin 9.
DOMAIN 1165 1269 Cadherin 10.
DOMAIN 1270 1374 Cadherin 11.
DOMAIN 1375 1478 Cadherin 12.
DOMAIN 1479 1583 Cadherin 13.
DOMAIN 1584 1685 Cadherin 14.
DOMAIN 1685 1787 Cadherin 15.
DOMAIN 1788 1892 Cadherin 16.
DOMAIN 1892 1992 Cadherin 17.
DOMAIN 1993 2094 Cadherin 18.
DOMAIN 2095 2210 Cadherin 19.
DOMAIN 2211 2314 Cadherin 20.
DOMAIN 2315 2425 Cadherin 21.
DOMAIN 2426 2533 Cadherin 22.
Amino Acid Sequence for PCD23_HUMAN » Protocadherin-23
MRLDEITKSE NEDGEKKMFT QQFESTDACV YEVYVKINSI VKSQSQCGLK RGSPETELWG AIVFRSQEEN AKPVKETEVT ASDADSGLYG FIEYSLYDGF LSYEAPQAFR IDPHDGQICV SQDIDRERDP ATYDLLVEAK DGDEQRMTHL ALVKGGLSAQ AFVRVDLEDV NDNHPVFNPS TYVTSISDET QPGTEIINVL ATDQDSGIYG TVAYELIPGN VSSLFTIDST TGLYSPEVEI LSAVNFSADK EVMNSLEMFL PLLRHFKKVE RDEEAAEKKF EASRGWFMRF KGRRHLHYLK VQDEAASADG EAAARYVANL AKILGEGIIY LTLPLSHLES TTLSLMVSAQ DGGGLTAVIN ADVTIHIFQT TLAPAEFERP KYTFLVYEDV PEDSPIGTVK AREPLNSSEP IFYRISSGDL GGKFSIHPRL GTIRTRKPLD HETQPVVVLT VQAQLGSAPA CSSTEVNITV MDVNDNHPAF LRTSDEIRIS QTTPPGTALY LARAEDRDSG RNGLIRYSIA SPQPGVFAID RALGVLFLNG SLGAGEQREL TLTLRAEDQG VHPQAALLVL TVVIEKREHS PSWTFEHLVY QVEVSESLSP MTQMLQTQAH PLGPQRAASP LRYSLEPSVD SAMFGIRPYT GWIYLRRQFD YESTQTYNFR VFAWIPEDGF LQNVSTTVIV RVWDENDNSP TFLHDVLFLK VEESPVPQGV IGKITAIDMD SGKNGQLLYF LLSDGKFFKM NPNTGPAGTI YVITWADGAA AFSGTDFAFS SDELQAFVLK SLFCELGEGE LINWVALDRE HRGHHEMTVL VTDRGSPPRN ATMAVYVSVT DINDNRPFFP QCLPGKELHV KVLEGQPVNM LVTTVFAKDP DEGNNAEVTY SVSSEDSSDH FKIDANNGEI RTTTILSYDY RPSYRMSVIA TDQGVPPLQG QAVVNIQVIP LSKGRAIMSQ NIRHLIIPEN LKPTKIMSLI KSSDHLQQHY NGKLHFSIVA DDKDGHFEID SSTGDLFLSK ELDYETTSHY LFRVITTDHS KNLSLSSTVF LSIDVEDQND HSPSFQDELI VISVEENVPI GTLVYVFNAK DDDGSFLNSR IQYYIESHNP GTNPFLIHPS FGTLVTVSRL DRESIPTVIL TVTASDQAVN VTDRRLRSLT AQIVILDVND HNPTFISFPN AHVKEDVTVG SLVHHITAHD PDEGRNGKVT YSILSGNENM TFMLDESSGL LTTTCPLDYE MKTQHILTVL ALDDGTPALS SSQTLTVTVL DVNDEAPVFK QHLYEASVKE NQNPGEFVTR VEALDRDSGV NSKLQFEIMP GASFELFEIN SDTGEVVTTT ILDREIQEVF TLRVLVRDGG FPSLSSTTTI LCTVEDENDH APEFIVSSYD IEVLENQEPE VVYTVLASDM DAGNNRAVEY HIIDGNTDEC FTINEMSGEL STTRALDREQ ISNFTLVILC SDLGDPPRSS VIHLQVRVLD ANDHSPSFPT LYYQSSVRED AEVGTVVLVL SAVDKDEGLN GQTEYFLTDE ASGAFTIDPM SGTLKTSNTL DREARSQHTF SAVARDCSIQ GSRSTTVIIK VYVTDVNDND PVLEQNPFDV FLSPESPTNQ TTVIVRADDL DLGPNGTVVF SFAETQSMFS IDKYTGEIQF QQNPSSEYFP IWLQLKVTDQ GIPARTTTGL LVIHMEGEDV KISFSHHLYK GLVTENCEAG TSIVTVKAFA PDSIQDSMKY SIFSGNEDGV LSLCSKSGQL TVKEPKFLDF EVRNEVQLIV LAESSGHRAY CKVAVLIQDE NDNSPCFEQS IYQASVSESQ LYNAHVIQVF ATDLDSGLNG LIEYSILSGN QEEAFQIDAL SGVITTKAIL DYELTSSYSL IVQATDKGMP RLSNTTVIKV QVTDINDNAP AFLPSEAVEI TEDSLPGVIV THVSVHDVDL NSAFIFSFAK ESNPGTKFAI DQNTGVVVLV KTLDFEEMTE YELLIQISDS VHYTEGALVV RVLDVNDNPP VFSQDFYQVT VPESIPVGYS VLTLSATDLE SNENISYRIL SSSKEFSIDP KNGTIFTISP VLLLDTISTT QFLVEASDGG NPDLRALTLV EIGIEDMNNY APEFTVKSYN LSLSEDALVG STLVTFSNID HDWTRENTYV EYSIISGNSQ NNFHVETKFF HSEYPYKQVG YLVLLHSLDR EASASHELVI LASDSGCPPL SSTAVISIQV LDVNDNPPNF SSLSYHTHVK ESTPLGSHIT VVSANDRDTG SHAEIIYNII SGNEKGHFYL EENTGVLYLI KPLDYEKMTK FTLTVQASDA EKKHFSFAVV FVSVLDDNDH APQFMFSSFS CIVPENLPIS STICSINALD FDAGPYGELT YSIVSPCFLT HGMSYDHDLF LIDPLTGDIH AKQILDYENG NKYCLTVQAK DKGDATASLV VWVDIEGIDE FEPIFTQDQY FFTLPEKNKD RQLIGRVEAS DADAGIDGVI LYSLGTSSPF FSVNKTNGNI YLIRALPLIK SQLNKEDTLE MKIIAHSPKS DSKFASCTVF VNVSFSSEGT PLAVFASSFS ISLVVSFLVF LILICILIVM ILRHKQKDTI NNYEEKKTSS LDADLRVTRD ASVLKAFQKT DDCSNEVVPV DATPEWLSLI SIMEKDIVNL YRHSNSSGHC SVEGETAEDK EIQRINEHPY RKCSDSALSD HESRVPDSGI PRDSDQLSCL SGETDVMVTA ETAEASQTFG EGDQGEGCST TCAQNNVLPQ TVQKREAKES ILADVRKESV FISGDQEVRC AALSTQTTSD HDGKDNYHWN YLLSWEPKFQ PLASVFNDIA KLKDEHLHMP GIPKEKKSFV FPPPLITAVA QPGIKAVPPR MPAVNLGQVP PKHPRSPIPY HLGSLPEGMT PNFSPSLSLL TMQPPALSPL LREGELLGTH ISGTCHELKA EDEVQI