PCD18_HUMAN » Protocadherin-18

PCD18_HUMAN » Protocadherin-18
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCD18_HUMAN » Protocadherin-18 »
Hydrophobic Thickness 34.2 ± 1.1 Å
Tilt Angle 0 ± 0°
ΔGtransfer -26.4 kcal/mol
ΔGfold -25.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 700-722 (698-728)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 29-113, PDBID: 1WUZ, Subunit A, Seq Identity:33%, Cadherin-like

AA: 142-237, PDBID: 4ZI8, Subunit B, Seq Identity:50%, Cadherin domain

AA: 251-345, PDBID: 4ZI8, Subunit B, Seq Identity:45%, Cadherin domain

AA: 367-456, PDBID: 3UBH, Subunit A, Seq Identity:32%, Cadherin domain

AA: 470-567, PDBID: 2YST, Subunit A, Seq Identity:35%, Cadherin domain

AA: 586-676, PDBID: 3UBH, Subunit A, Seq Identity:28%, Cadherin domain

UniProt annotation for PCD18_HUMAN » Protocadherin-18
FUNCTION: Potential calcium-dependent cell-adhesion protein.

SUBUNIT: Interacts with DAB1.

TISSUE SPECIFICITY: Expressed in all tissues, with highest expression in lung and ovary.

UniProt features for PCD18_HUMAN » Protocadherin-18
SIGNAL 1 27 Potential.
CHAIN 28 1135 Protocadherin-18.
DOMAIN 28 137 Cadherin 1.
DOMAIN 138 246 Cadherin 2.
DOMAIN 247 354 Cadherin 3.
DOMAIN 361 465 Cadherin 4.
DOMAIN 466 576 Cadherin 5.
DOMAIN 582 688 Cadherin 6.
REGION 893 1135 Interaction with DAB1 (By similarity).
Amino Acid Sequence for PCD18_HUMAN » Protocadherin-18
MHQMNAKMHF RFVFALLIVS FNHDVLGKNL KYRIYEEQRV GSVIARLSED VADVLLKLPN PSTVRFRAMQ RGNSPLLVVN EDNGEISIGA TIDREQLCQK NLNCSIEFDV ITLPTEHLQL FHIEVEVLDI NDNSPQFSRS LIPIEISESA AVGTRIPLDS AFDPDVGENS LHTYSLSAND FFNIEVRTRT DGAKYAELIV VRELDRELKS SYELQLTASD MGVPQRSGSS ILKISISDSN DNSPAFEQQS YIIQLLENSP VGTLLLDLNA TDPDEGANGK IVYSFSSHVS PKIMETFKID SERGHLTLFK QVDYEITKSY EIDVQAQDLG PNSIPAHCKI IIKVVDVNDN KPEININLMS PGKEEISYIF EGDPIDTFVA LVRVQDKDSG LNGEIVCKLH GHGHFKLQKT YENNYLILTN ATLDREKRSE YSLTVIAEDR GTPSLSTVKH FTVQINDIND NPPHFQRSRY EFVISENNSP GAYITTVTAT DPDLGENGQV TYTILESFIL GSSITTYVTI DPSNGAIYAL RIFDHEEVSQ ITFVVEARDG GSPKQLVSNT TVVLTIIDEN DNVPVVIGPA LRNNTAEITI PKGAESGFHV TRIRAIDRDS GVNAELSCAI VAGNEENIFI IDPRSCDIHT NVSMDSVPYT EWELSVIIQD KGNPQLHTKV LLKCMIFEYA ESVTSTAMTS VSQASLDVSM IIIISLGAIC AVLLVIMVLF ATRCNREKKD TRSYNCRVAE STYQHHPKRP SRQIHKGDIT LVPTINGTLP IRSHHRSSPS SSPTLERGQM GSRQSHNSHQ SLNSLVTISS NHVPENFSLE LTHATPAVEQ VSQLLSMLHQ GQYQPRPSFR GNKYSRSYRY ALQDMDKFSL KDSGRGDSEA GDSDYDLGRD SPIDRLLGEG FSDLFLTDGR IPAAMRLCTE ECRVLGHSDQ CWMPPLPSPS SDYRSNMFIP GEEFPTQPQQ QHPHQSLEDD AQPADSGEKK KSFSTFGKDS PNDEDTGDTS TSSLLSEMSS VFQRLLPPSL DTYSECSEVD RSNSLERRKG PLPAKTVGYP QGVAAWAAST HFQNPTTNCG PPLGTHSSVQ PSSKWLPAME EIPENYEEDD FDNVLNHLND GKHELMDASE LVAEINKLLQ DVRQS