PCD17_HUMAN » Protocadherin-17

PCD17_HUMAN » Protocadherin-17
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCD17_HUMAN » Protocadherin-17 » Protocadherin-68;
Hydrophobic Thickness 34.4 ± 3.0 Å
Tilt Angle 24 ± 9°
ΔGtransfer -24.5 kcal/mol
ΔGfold -20.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 706-730 (706-733)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ZP3, Complex: PCD17:ZP3, PubMed

Domains

AA: 20-112, PDBID: 4ZPM, Subunit B, Seq Identity:36%, Cadherin-like

AA: 137-234, PDBID: 4ZPN, Subunit B, Seq Identity:56%, Cadherin domain

AA: 248-342, PDBID: 4ZPM, Subunit A, Seq Identity:60%, Cadherin domain

AA: 357-463, PDBID: 4ZPL, Subunit A, Seq Identity:31%, Cadherin domain

AA: 477-574, PDBID: 4ZI9, Subunit B, Seq Identity:31%, Cadherin domain

AA: 593-682, PDBID: 3UBH, Subunit A, Seq Identity:32%, Cadherin domain

UniProt annotation for PCD17_HUMAN » Protocadherin-17
FUNCTION: Potential calcium-dependent cell-adhesion protein.

DEVELOPMENTAL STAGE: During midgestation, enriched in the frontal and anterior temporal cortices. Expressed at high levels in the exterior margins of the thalamus, ventromedial striatal neuroepithelium and anterior cingulate.

UniProt features for PCD17_HUMAN » Protocadherin-17
SIGNAL 1 17 Potential.
CHAIN 18 1159 Protocadherin-17.
DOMAIN 18 132 Cadherin 1.
DOMAIN 133 243 Cadherin 2.
DOMAIN 244 351 Cadherin 3.
DOMAIN 353 472 Cadherin 4.
DOMAIN 473 583 Cadherin 5.
DOMAIN 589 695 Cadherin 6.
MOTIF 186 188 Cell attachment site (Potential).
Amino Acid Sequence for PCD17_HUMAN » Protocadherin-17
MYLSICCCFL LWAPALTLKN LNYSVPEEQG AGTVIGNIGR DARLQPGLPP AERGGGGRSK SGSYRVLENS APHLLDVDAD SGLLYTKQRI DRESLCRHNA KCQLSLEVFA NDKEICMIKV EIQDINDNAP SFSSDQIEMD ISENAAPGTR FPLTSAHDPD AGENGLRTYL LTRDDHGLFG LDVKSRGDGT KFPELVIQKA LDREQQNHHT LVLTALDGGE PPRSATVQIN VKVIDSNDNS PVFEAPSYLV ELPENAPLGT VVIDLNATDA DEGPNGEVLY SFSSYVPDRV RELFSIDPKT GLIRVKGNLD YEENGMLEID VQARDLGPNP IPAHCKVTVK LIDRNDNAPS IGFVSVRQGA LSEAAPPGTV IALVRVTDRD SGKNGQLQCR VLGGGGTGGG GGLGGPGGSV PFKLEENYDN FYTVVTDRPL DRETQDEYNV TIVARDGGSP PLNSTKSFAI KILDENDNPP RFTKGLYVLQ VHENNIPGEY LGSVLAQDPD LGQNGTVSYS ILPSHIGDVS IYTYVSVNPT NGAIYALRSF NFEQTKAFEF KVLAKDSGAP AHLESNATVR VTVLDVNDNA PVIVLPTLQN DTAELQVPRN AGLGYLVSTV RALDSDFGES GRLTYEIVDG NDDHLFEIDP SSGEIRTLHP FWEDVTPVVE LVVKVTDHGK PTLSAVAKLI IRSVSGSLPE GVPRVNGEQH HWDMSLPLIV TLSTISIILL AAMITIAVKC KRENKEIRTY NCRIAEYSHP QLGGGKGKKK KINKNDIMLV QSEVEERNAM NVMNVVSSPS LATSPMYFDY QTRLPLSSPR SEVMYLKPAS NNLTVPQGHA GCHTSFTGQG TNASETPATR MSIIQTDNFP AEPNYMGSRQ QFVQSSSTFK DPERASLRDS GHGDSDQADS DQDTNKGSCC DMSVREALKM KTTSTKSQPL EQEPEECVNC TDECRVLGHS DRCWMPQFPA ANQAENADYR TNLFVPTVEA NVETETYETV NPTGKKTFCT FGKDKREHTI LIANVKPYLK AKRALSPLLQ EVPSASSSPT KACIEPCTST KGSLDGCEAK PGALAEASSQ YLPTDSQYLS PSKQPRDPPF MASDQMARVF ADVHSRASRD SSEMGAVLEQ LDHPNRDLGR ESVDAEEVVR EIDKLLQDCR GNDPVAVRK