PCD16_HUMAN » Protocadherin-16

PCD16_HUMAN » Protocadherin-16
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCD16_HUMAN » Protocadherin-16 » Cadherin-19;Cadherin-25;Fibroblast cadherin-1;Protein dachsous homolog 1;
Hydrophobic Thickness 38.8 ± 1.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -52.1 kcal/mol
ΔGfold -24.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 2935-2960 (2935-2966)
Pathways none
PDB none
OPM none
Complexes none
Interactions

BAK, Complex: PCD16:BAK, PubMed

ESR1, Complex: ESR1:PCD16, PubMed

RYK, Complex: PCD16:RYK, PubMed

TNR5, Complex: TNR5:PCD16, PubMed

Domains

AA: 149-246, PDBID: 4ZPS, Subunit A, Seq Identity:42%, Cadherin domain

AA: 260-353, PDBID: 4ZI8, Subunit B, Seq Identity:40%, Cadherin domain

AA: 372-463, PDBID: 4ZPL, Subunit A, Seq Identity:32%, Cadherin domain

AA: 479-569, PDBID: 4ZPM, Subunit A, Seq Identity:39%, Cadherin domain

AA: 583-675, PDBID: 2YST, Subunit A, Seq Identity:32%, Cadherin domain

AA: 690-781, PDBID: 2YST, Subunit A, Seq Identity:35%, Cadherin domain

AA: 795-885, PDBID: 4ZI9, Subunit B, Seq Identity:34%, Cadherin domain

AA: 900-989, PDBID: 4ZI8, Subunit B, Seq Identity:33%, Cadherin domain

AA: 1005-1096, PDBID: 2YST, Subunit A, Seq Identity:31%, Cadherin domain

AA: 1111-1202, PDBID: 4ZPM, Subunit A, Seq Identity:39%, Cadherin domain

AA: 1222-1312, PDBID: 4ZPL, Subunit A, Seq Identity:36%, Cadherin domain

AA: 1442-1537, PDBID: 2EE0, Subunit A, Seq Identity:31%, Cadherin domain

AA: 1550-1640, PDBID: 4ZPS, Subunit A, Seq Identity:38%, Cadherin domain

AA: 1654-1742, PDBID: 2YST, Subunit A, Seq Identity:41%, Cadherin domain

AA: 1756-1846, PDBID: 4ZI8, Subunit B, Seq Identity:35%, Cadherin domain

AA: 1860-1951, PDBID: 4ZI9, Subunit B, Seq Identity:41%, Cadherin domain

AA: 2073-2162, PDBID: 4ZPS, Subunit A, Seq Identity:33%, Cadherin domain

AA: 2176-2268, PDBID: 2YST, Subunit A, Seq Identity:38%, Cadherin domain

AA: 2282-2367, PDBID: 4ZPL, Subunit A, Seq Identity:32%, Cadherin domain

AA: 2381-2473, PDBID: 3UBH, Subunit A, Seq Identity:34%, Cadherin domain

AA: 2487-2593, PDBID: 4ZI9, Subunit B, Seq Identity:32%, Cadherin domain

AA: 2607-2697, PDBID: 4ZI9, Subunit B, Seq Identity:37%, Cadherin domain

AA: 2711-2804, PDBID: 4ZI9, Subunit B, Seq Identity:36%, Cadherin domain

UniProt annotation for PCD16_HUMAN » Protocadherin-16
FUNCTION: Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation.

SUBUNIT: Heterophilic interaction with FAT4; this interaction affects their respective protein levels.

TISSUE SPECIFICITY: Expressed in fibroblasts but not in melanocytes or keratinocytes.

DISEASE: Van Maldergem syndrome 1 (VMLDS1) OMIM: An autosomal recessive disorder characterized by intellectual disability, typical craniofacial features, auditory malformations resulting in hearing loss, and skeletal and limb malformations. Some patients have renal hypoplasia. Brain MRI typically shows periventricular nodular heterotopia. mutations affecting the gene represented in this entry.

UniProt features for PCD16_HUMAN » Protocadherin-16
SIGNAL 1 42 Potential.
CHAIN 43 3298 Protocadherin-16.
DOMAIN 43 143 Cadherin 1.
DOMAIN 144 255 Cadherin 2.
DOMAIN 256 362 Cadherin 3.
DOMAIN 367 472 Cadherin 4.
DOMAIN 474 578 Cadherin 5.
DOMAIN 579 685 Cadherin 6.
DOMAIN 686 790 Cadherin 7.
DOMAIN 791 894 Cadherin 8.
DOMAIN 895 1000 Cadherin 9.
DOMAIN 1001 1111 Cadherin 10.
DOMAIN 1112 1211 Cadherin 11.
DOMAIN 1218 1324 Cadherin 12.
DOMAIN 1333 1436 Cadherin 13.
DOMAIN 1437 1546 Cadherin 14.
DOMAIN 1547 1649 Cadherin 15.
DOMAIN 1650 1751 Cadherin 16.
DOMAIN 1752 1855 Cadherin 17.
DOMAIN 1856 1960 Cadherin 18.
DOMAIN 1965 2068 Cadherin 19.
DOMAIN 2069 2171 Cadherin 20.
DOMAIN 2172 2277 Cadherin 21.
DOMAIN 2278 2376 Cadherin 22.
DOMAIN 2377 2482 Cadherin 23.
DOMAIN 2483 2602 Cadherin 24.
DOMAIN 2603 2706 Cadherin 25.
DOMAIN 2707 2813 Cadherin 26.
DOMAIN 2814 2933 Cadherin 27.
Amino Acid Sequence for PCD16_HUMAN » Protocadherin-16
MQKELGIVPS CPGMKSPRPH LLLPLLLLLL LLLGAGVPGA WGQAGSLDLQ IDEEQPAGTL IGDISAGLPA GTAAPLMYFI SAQEGSGVGT DLAIDEHSGV VRTARVLDRE QRDRYRFTAV TPDGATVEVT VRVADINDHA PAFPQARAAL QVPEHTAFGT RYPLEPARDA DAGRLGTQGY ALSGDGAGET FRLETRPGPD GTPVPELVVT GELDRENRSH YMLQLEAYDG GSPPRRAQAL LDVTLLDIND HAPAFNQSRY HAVVSESLAP GSPVLQVFAS DADAGVNGAV TYEINRRQSE GDGPFSIDAH TGLLQLERPL DFEQRRVHEL VVQARDGGAH PELGSAFVTV HVRDANDNQP SMTVIFLSAD GSPQVSEAAP PGQLVARISV SDPDDGDFAH VNVSLEGGEG HFALSTQDSV IYLVCVARRL DREERDAYNL RVTATDSGSP PLRAEAAFVL HVTDVNDNAP AFDRQLYRPE PLPEVALPGS FVVRVTARDP DQGTNGQVTY SLAPGAHTHW FSIDPTSGII TTAASLDYEL EPQPQLIVVA TDGGLPPLAS SATVSVALQD VNDNEPQFQR TFYNASLPEG TQPGTCFLQV TATDADSGPF GLLSYSLGAG LGSSGSPPFR IDAHSGDVCT TRTLDRDQGP SSFDFTVTAV DGGGLKSMVY VKVFLSDEND NPPQFYPREY AASISAQSPP GTAVLRLRAH DPDQGSHGRL SYHILAGNSP PLFTLDEQSG LLTVAWPLAR RANSVVQLEI GAEDGGGLQA EPSARVDISI VPGTPTPPIF EQLQYVFSVP EDVAPGTSVG IVQAHNPPGR LAPVTLSLSG GDPRGLFSLD AVSGLLQTLR PLDRELLGPV LELEVRAGSG VPPAFAVARV RVLLDDVNDN SPAFPAPEDT VLLPPNTAPG TPIYTLRALD PDSGVNSRVT FTLLAGGGGA FTVDPTTGHV RLMRPLGPSG GPAHELELEA RDGGSPPRTS HFRLRVVVQD VGTRGLAPRF NSPTYRVDLP SGTTAGTQVL QVQAQAPDGG PITYHLAAEG ASSPFGLEPQ SGWLWVRAAL DREAQELYIL KVMAVSGSKA ELGQQTGTAT VRVSILNQNE HSPRLSEDPT FLAVAENQPP GTSVGRVFAT DRDSGPNGRL TYSLQQLSED SKAFRIHPQT GEVTTLQTLD REQQSSYQLL VQVQDGGSPP RSTTGTVHVA VLDLNDNSPT FLQASGAAGG GLPIQVPDRV PPGTLVTTLQ AKDPDEGENG TILYTLTGPG SELFSLHPHS GELLTAAPLI RAERPHYVLT LSAHDQGSPP RSASLQLLVQ VLPSARLAEP PPDLAERDPA APVPVVLTVT AAEGLRPGSL LGSVAAPEPA GVGALTYTLV GGADPEGTFA LDAASGRLYL ARPLDFEAGP PWRALTVRAE GPGGAGARLL RVQVQVQDEN EHAPAFARDP LALALPENPE PGAALYTFRA SDADGPGPNS DVRYRLLRQE PPVPALRLDA RTGALSAPRG LDRETTPALL LLVEATDRPA NASRRRAARV SARVFVTDEN DNAPVFASPS RVRLPEDQPP GPAALHVVAR DPDLGEAARV SYRLASGGDG HFRLHSSTGA LSVVRPLDRE QRAEHVLTVV ASDHGSPPRS ATQVLTVSVA DVNDEAPTFQ QQEYSVLLRE NNPPGTSLLT LRATDPDVGA NGQVTYGGVS SESFSLDPDT GVLTTLRALD REEQEEINLT VYAQDRGSPP QLTHVTVRVA VEDENDHAPT FGSAHLSLEV PEGQDPQTLT MLRASDPDVG ANGQLQYRIL DGDPSGAFVL DLASGEFGTM RPLDREVEPA FQLRIEARDG GQPALSATLL LTVTVLDAND HAPAFPVPAY SVEVPEDVPA GTLLLQLQAH DPDAGANGHV TYYLGAGTAG AFLLEPSSGE LRTAAALDRE QCPSYTFSVS AVDGAAAGPL STTVSVTITV RDVNDHAPTF PTSPLRLRLP RPGPSFSTPT LALATLRAED RDAGANASIL YRLAGTPPPG TTVDSYTGEI RVARSPVALG PRDRVLFIVA TDLGRPARSA TGVIIVGLQG EAERGPRFPR ASSEATIREN APPGTPIVSP RAVHAGGTNG PITYSILSGN EKGTFSIQPS TGAITVRSAE GLDFEVSPRL RLVLQAESGG AFAFTVLTLT LQDANDNAPR FLRPHYVAFL PESRPLEGPL LQVEADDLDQ GSGGQISYSL AASQPARGLF HVDPTTGTIT TTAILDREIW AETRLVLMAT DRGSPALVGS ATLTVMVIDT NDNRPTIPQP WELRVSEDAL LGSEIAQVTG NDVDSGPVLW YVLSPSGPQD PFSVGRYGGR VSLTGPLDFE QCDRYQLQLL AHDGPHEGRA NLTVLVEDVN DNAPAFSQSL YQVMLLEHTP PGSAILSVSA TDRDSGANGH ISYHLASPAD GFSVDPNNGT LFTIVGTVAL GHDGSGAVDV VLEARDHGAP GRAARATVHV QLQDQNDHAP SFTLSHYRVA VTEDLPPGST LLTLEATDAD GSRSHAAVDY SIISGNWGRV FQLEPRLAEA GESAGPGPRA LGCLVLLEPL DFESLTQYNL TVAAADRGQP PQSSVVPVTV TVLDVNDNPP VFTRASYRVT VPEDTPVGAE LLHVEASDAD PGPHGLVRFT VSSGDPSGLF ELDESSGTLR LAHALDCETQ ARHQLVVQAA DPAGAHFALA PVTIEVQDVN DHGPAFPLNL LSTSVAENQP PGTLVTTLHA IDGDAGAFGR LRYSLLEAGP GPEGREAFAL NSSTGELRAR VPFDYEHTES FRLLVGAADA GNLSASVTVS VLVTGEDEYD PVFLAPAFHF QVPEGARRGH SLGHVQATDE DGGADGLVLY SLATSSPYFG INQTTGALYL RVDSRAPGSG TATSGGGGRT RREAPRELRL EVIARGPLPG SRSATVPVTV DITHTALGLA PDLNLLLVGA VAASLGVVVV LALAALVLGL VRARSRKAEA APGPMSQAAP LASDSLQKLG REPPSPPPSE HLYHQTLPSY GGPGAGGPYP RGGSLDPSHS SGRGSAEAAE DDEIRMINEF PRVASVASSL AARGPDSGIQ QDADGLSDTS CEPPAPDTWY KGRKAGLLLP GAGATLYREE GPPATATAFL GGCGLSPAPT GDYGFPADGK PCVAGALTAI VAGEEELRGS YNWDYLLSWC PQFQPLASVF TEIARLKDEA RPCPPAPRID PPPLITAVAH PGAKSVPPKP ANTAAARAIF PPASHRSPIS HEGSLSSAAM SPSFSPSLSP LAARSPVVSP FGVAQGPSAS ALSAESGLEP PDDTELHI