PCD12_HUMAN » Protocadherin-12

PCD12_HUMAN » Protocadherin-12
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCD12_HUMAN » Protocadherin-12 » Vascular cadherin-2;Vascular endothelial cadherin-2;VE-cad-2; VE-cadherin-2;
Hydrophobic Thickness 32.4 ± 1.8 Å
Tilt Angle 6 ± 5°
ΔGtransfer -45.7 kcal/mol
ΔGfold -25.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 715-743 (714-744)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 31-114, PDBID: 1WYJ, Subunit A, Seq Identity:34%, Cadherin-like

AA: 140-235, PDBID: 4ZPN, Subunit B, Seq Identity:52%, Cadherin domain

AA: 249-343, PDBID: 4ZPM, Subunit A, Seq Identity:44%, Cadherin domain

AA: 360-451, PDBID: 4ZPL, Subunit A, Seq Identity:36%, Cadherin domain

AA: 465-556, PDBID: 4ZPM, Subunit A, Seq Identity:33%, Cadherin domain

AA: 612-694, PDBID: 4ZPN, Subunit B, Seq Identity:28%, Cadherin domain

UniProt annotation for PCD12_HUMAN » Protocadherin-12
FUNCTION: Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity).

TISSUE SPECIFICITY: Expressed in highly vascularized tissues including the heart and placenta, but most tissues contain a low level of expression. Prominent expression in the spleen.

UniProt features for PCD12_HUMAN » Protocadherin-12
SIGNAL 1 24 Potential.
CHAIN 25 1184 Protocadherin-12.
DOMAIN 28 135 Cadherin 1.
DOMAIN 136 244 Cadherin 2.
DOMAIN 245 352 Cadherin 3.
DOMAIN 355 460 Cadherin 4.
DOMAIN 461 565 Cadherin 5.
DOMAIN 600 711 Cadherin 6.
Amino Acid Sequence for PCD12_HUMAN » Protocadherin-12
MMQLLQLLLG LLGPGGYLFL LGDCQEVTTL TVKYQVSEEV PSGTVIGKLS QELGREERRR QAGAAFQVLQ LPQALPIQVD SEEGLLSTGR RLDREQLCRQ WDPCLVSFDV LATGDLALIH VEIQVLDIND HQPRFPKGEQ ELEISESASL RTRIPLDRAL DPDTGPNTLH TYTLSPSEHF ALDVIVGPDE TKHAELIVVK ELDREIHSFF DLVLTAYDNG NPPKSGTSLV KVNVLDSNDN SPAFAESSLA LEIQEDAAPG TLLIKLTATD PDQGPNGEVE FFLSKHMPPE VLDTFSIDAK TGQVILRRPL DYEKNPAYEV DVQARDLGPN PIPAHCKVLI KVLDVNDNIP SIHVTWASQP SLVSEALPKD SFIALVMADD LDSGHNGLVH CWLSQELGHF RLKRTNGNTY MLLTNATLDR EQWPKYTLTL LAQDQGLQPL SAKKQLSIQI SDINDNAPVF EKSRYEVSTR ENNLPSLHLI TIKAHDADLG INGKVSYRIQ DSPVAHLVAI DSNTGEVTAQ RSLNYEEMAG FEFQVIAEDS GQPMLASSVS VWVSLLDAND NAPEVVQPVL SDGKASLSVL VNASTGHLLV PIETPNGLGP AGTDTPPLAT HSSRPFLLTT IVARDADSGA NGEPLYSIRS GNEAHLFILN PHTGQLFVNV TNASSLIGSE WELEIVVEDQ GSPPLQTRAL LRVMFVTSVD HLRDSARKPG ALSMSMLTVI CLAVLLGIFG LILALFMSIC RTEKKDNRAY NCREAESTYR QQPKRPQKHI QKADIHLVPV LRGQAGEPCE VGQSHKDVDK EAMMEAGWDP CLQAPFHLTP TLYRTLRNQG NQGAPAESRE VLQDTVNLLF NHPRQRNASR ENLNLPEPQP ATGQPRSRPL KVAGSPTGRL AGDQGSEEAP QRPPASSATL RRQRHLNGKV SPEKESGPRQ ILRSLVRLSV AAFAERNPVE ELTVDSPPVQ QISQLLSLLH QGQFQPKPNH RGNKYLAKPG GSRSAIPDTD GPSARAGGQT DPEQEEGPLD PEEDLSVKQL LEEELSSLLD PSTGLALDRL SAPDPAWMAR LSLPLTTNYR DNVISPDAAA TEEPRTFQTF GKAEAPELSP TGTRLASTFV SEMSSLLEML LEQRSSMPVE AASEALRRLS VCGRTLSLDL ATSAASGMKV QGDPGGKTGT EGKSRGSSSS SRCL