PCD10_HUMAN » Protocadherin-10

PCD10_HUMAN » Protocadherin-10
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCD10_HUMAN » Protocadherin-10 »
Hydrophobic Thickness 34.4 ± 3.2 Å
Tilt Angle 21 ± 6°
ΔGtransfer -27.3 kcal/mol
ΔGfold -25.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 714-738 (714-744)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 19-101, PDBID: 1WUZ, Subunit A, Seq Identity:48%, Cadherin-like

AA: 127-241, PDBID: 4ZPN, Subunit B, Seq Identity:41%, Cadherin domain

AA: 255-349, PDBID: 4ZPM, Subunit A, Seq Identity:60%, Cadherin domain

AA: 364-454, PDBID: 4ZPL, Subunit A, Seq Identity:35%, Cadherin domain

AA: 468-565, PDBID: 3LND, Subunit B, Seq Identity:32%, Cadherin domain

AA: 589-679, PDBID: 3PPE, Subunit A, Seq Identity:31%, Cadherin domain

AA: 713-838, Cadherin cytoplasmic C-terminal

UniProt annotation for PCD10_HUMAN » Protocadherin-10
FUNCTION: Potential calcium-dependent cell-adhesion protein.

TISSUE SPECIFICITY: Moderately expressed in all regions of the brain examined, as well as in testis and ovary, and low expression in all other tissues tested.

UniProt features for PCD10_HUMAN » Protocadherin-10
SIGNAL 1 18 Potential.
CHAIN 19 1040 Protocadherin-10.
DOMAIN 19 122 Cadherin 1.
DOMAIN 123 250 Cadherin 2.
DOMAIN 251 358 Cadherin 3.
DOMAIN 359 463 Cadherin 4.
DOMAIN 464 574 Cadherin 5.
DOMAIN 582 690 Cadherin 6.
Amino Acid Sequence for PCD10_HUMAN » Protocadherin-10
MIVLLLFALL WMVEGVFSQL HYTVQEEQEH GTFVGNIAED LGLDITKLSA RGFQTVPNSR TPYLDLNLET GVLYVNEKID REQICKQSPS CVLHLEVFLE NPLELFQVEI EVLDINDNPP SFPEPDLTVE ISESATPGTR FPLESAFDPD VGTNSLRDYE ITPNSYFSLD VQTQGDGNRF AELVLEKPLD REQQAVHRYV LTAVDGGGGG GVGEGGGGGG GAGLPPQQQR TGTALLTIRV LDSNDNVPAF DQPVYTVSLP ENSPPGTLVI QLNATDPDEG QNGEVVYSFS SHISPRAREL FGLSPRTGRL EVSGELDYEE SPVYQVYVQA KDLGPNAVPA HCKVLVRVLD ANDNAPEISF STVKEAVSEG AAPGTVVALF SVTDRDSEEN GQVQCELLGD VPFRLKSSFK NYYTIVTEAP LDREAGDSYT LTVVARDRGE PALSTSKSIQ VQVSDVNDNA PRFSQPVYDV YVTENNVPGA YIYAVSATDR DEGANAQLAY SILECQIQGM SVFTYVSINS ENGYLYALRS FDYEQLKDFS FQVEARDAGS PQALAGNATV NILIVDQNDN APAIVAPLPG RNGTPAREVL PRSAEPGYLL TRVAAVDADD GENARLTYSI VRGNEMNLFR MDWRTGELRT ARRVPAKRDP QRPYELVIEV RDHGQPPLSS TATLVVQLVD GAVEPQGGGG SGGGGSGEHQ RPSRSGGGET SLDLTLILII ALGSVSFIFL LAMIVLAVRC QKEKKLNIYT CLASDCCLCC CCCGGGGSTC CGRQARARKK KLSKSDIMLV QSSNVPSNPA QVPIEESGGF GSHHHNQNYC YQVCLTPESA KTDLMFLKPC SPSRSTDTEH NPCGAIVTGY TDQQPDIISN GSILSNETKH QRAELSYLVD RPRRVNSSAF QEADIVSSKD SGHGDSEQGD SDHDATNRAQ SAGMDLFSNC TEECKALGHS DRCWMPSFVP SDGRQAADYR SNLHVPGMDS VPDTEVFETP EAQPGAERSF STFGKEKALH STLERKELDG LLTNTRAPYK PPYLTRKRIC