PCAT1_HUMAN » Lysophosphatidylcholine acyltransferase 1
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Topology in Golgi apparatus membrane
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Topology in Golgi apparatus membrane
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- Type: 1. Transmembrane bitopic proteins (15 classes)
- Class: 1.10. Enzymes, transferases (EC 2.) (29 superfamilies)
- Superfamily: 1.10.04. Phospholipid/glycerol acyltransferase (2 families) PF01553 (Pfam)
- Family: 1.10.04.01. Phospholipid/glycerol acyltransferase (2 proteins) IPR002123 (InterPro)
- Species: Homo sapiens (2303 proteins)
- Localization: Golgi apparatus membrane (150 proteins)
| PCAT1_HUMAN » Lysophosphatidylcholine acyltransferase 1 » LysoPC acyltransferase 1; LPC acyltransferase 1; LPCAT-1; 1-alkylglycerophosphocholine O-acetyltransferase;Acetyl-CoA:lyso-platelet-activating factor acetyltransferase;Acetyl-CoA:lyso-PAF acetyltransferase; Lyso-PAF acetyltransferase; LysoPAFAT; 1-acylgly | |
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| Hydrophobic Thickness | 30.8 ± 3.2 Å |
| Tilt Angle | 30 ± 4° |
| ΔGtransfer | -12.4 kcal/mol |
| Links to PCAT1_HUMAN | UniProtKB, Pfam, iHOP, STRING, PharmGKB, HGNC, Wikipedia, Interpro |
| Topology | Out |
| Domains | AA: 114-236, PDBID: 1k30, Subunit A, Seq Identity:9%, Acyltransferase |
| Transmembrane segments |
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| Segments: 55-81 |
| Uniprot annotation for PCAT1_HUMAN » Lysophosphatidylcholine acyltransferase 1 |
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FUNCTION: Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent. Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology. CATALYTIC ACTIVITY: Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine. CATALYTIC ACTIVITY: Acetyl-CoA + 1-alkyl-sn-glycero-3- phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3- phosphocholine. ENZYME REGULATION: Not activated by inflammatory stimulation. Inhibited by Cu(2+) and Fe(2+). Activity is not affected by Co(2+), Mg(2+) or Mn(2+) (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). DOMAIN: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine (By similarity). DOMAIN: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity). -- Uniprot annotation-- |
| Uniprot features for PCAT1_HUMAN » Lysophosphatidylcholine acyltransferase 1 |
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CHAIN 1 534 Lysophosphatidylcholine acyltransferase 1. DOMAIN 379 414 EF-hand 1. DOMAIN 451 486 EF-hand 2. MOTIF 135 140 HXXXXD motif. MOTIF 531 534 Di-lysine motif. |
