PC11Y_HUMAN » Protocadherin-11 Y-linked

PC11Y_HUMAN » Protocadherin-11 Y-linked
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PC11Y_HUMAN » Protocadherin-11 Y-linked » Protocadherin-11; Protocadherin on the Y chromosome;PCDH-Y; Protocadherin prostate cancer;Protocadherin-PC; Protocadherin-22;
Hydrophobic Thickness 34.0 ± 2.2 Å
Tilt Angle 2 ± 1°
ΔGtransfer -50.9 kcal/mol
ΔGfold -22.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 842-866 (840-871)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 57-147, PDBID: 1WYJ, Subunit A, Seq Identity:30%, Cadherin-like

AA: 176-272, PDBID: 4ZPS, Subunit A, Seq Identity:43%, Cadherin domain

AA: 286-378, PDBID: 2EE0, Subunit A, Seq Identity:67%, Cadherin domain

AA: 398-489, PDBID: 2WCP, Subunit A, Seq Identity:29%, Cadherin domain

AA: 503-593, PDBID: 2EE0, Subunit A, Seq Identity:41%, Cadherin domain

AA: 607-696, PDBID: 4ZPL, Subunit A, Seq Identity:37%, Cadherin domain

AA: 714-805, PDBID: 2EE0, Subunit A, Seq Identity:33%, Cadherin domain

AA: 807-1030, Protocadherin

UniProt annotation for PC11Y_HUMAN » Protocadherin-11 Y-linked
FUNCTION: Potential calcium-dependent cell-adhesion protein.

SUBUNIT: Interacts with CTNNB1.

TISSUE SPECIFICITY: Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis. Expressed in apoptosis-resistant cells.

DISEASE: Note=A chromosomal aberration involving PCDH11Y is a cause of multiple congenital abnormalities, including severe bilateral vesicoureteral reflux (VUR) with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with ROBO2.

UniProt features for PC11Y_HUMAN » Protocadherin-11 Y-linked
SIGNAL 1 28 Potential.
CHAIN 29 1340 Protocadherin-11 Y-linked.
DOMAIN 58 171 Cadherin 1.
DOMAIN 172 281 Cadherin 2.
DOMAIN 282 387 Cadherin 3.
DOMAIN 394 498 Cadherin 4.
DOMAIN 499 602 Cadherin 5.
DOMAIN 603 705 Cadherin 6.
DOMAIN 709 827 Cadherin 7.
Amino Acid Sequence for PC11Y_HUMAN » Protocadherin-11 Y-linked
MFRVGFLIIS SSSSLSPLLL VSVVRVNTTN CHKCLLSGTY IFAVLLVCVV FHSGAQEKNY TIREEIPENV LIGNLLKDLN LSLIPNKSLT TTMQFKLVYK TGDVPLIRIE EDTGEIFTTG ARIDREKLCA GIPRDEHCFY EVEVAILPDE IFRLVKIRFL IEDINDNAPL FPATVINISI PENSAINSKY TLPAAVDPDV GINGVQNYEL IKSQNIFGLD VIETPEGDKM PQLIVQKELD REEKDTYVMK VKVEDGGFPQ RSSTAILQVS VTDTNDNHPV FKETEIEVSI PENAPVGTSV TQLHATDADI GENAKIHFSF SNLVSNIARR LFHLNATTGL ITIKEPLDRE ETPNHKLLVL ASDGGLMPAR AMVLVNVTDV NDNVPSIDIR YIVNPVNDTV VLSENIPLNT KIALITVTDK DADHNGRVTC FTDHEIPFRL RPVFSNQFLL ENAAYLDYES TKEYAIKLLA ADAGKPPLNQ SAMLFIKVKD ENDNAPVFTQ SFVTVSIPEN NSPGIQLMKV SATDADSGPN AEINYLLGPD APPEFSLDRR TGMLTVVKKL DREKEDKYLF TILAKDNGVP PLTSNVTVFV SIIDQNDNSP VFTHNEYKFY VPENLPRHGT VGLITVTDPD YGDNSAVTLS ILDENDDFTI DSQTGVIRPN ISFDREKQES YTFYVKAEDG GRVSRSSSAK VTINVVDVND NKPVFIVPPY NYSYELVLPS TNPGTVVFQV IAVDNDTGMN AEVRYSIVGG NTRDLFAIDQ ETGNITLMEK CDVTDLGLHR VLVKANDLGQ PDSLFSVVIV NLFVNESVTN ATLINELVRK SIEAPVTPNT EIADVSSPTS DYVKILVAAV AGTITVVVVI FITAVVRCRQ APHLKAAQKN MQNSEWATPN PENRQMIMMK KKKKKKKHSP KNLLLNVVTI EETKADDVDS DGNRVTLDLP IDLEEQTMGK YNWVTTPTTF KPDSPDLARH YKSASPQPAF QIQPETPLNL KHHIIQELPL DNTFVACDSI SNCSSSSSDP YSVSDCGYPV TTFEVPVSVH TRPSQRRVTF HLPEGSQESS SDGGLGDHDA GSLTSTSHGL PLGYPQEEYF DRATPSNRTE GDGNSDPEST FIPGLKKEIT VQPTVEEASD NCTQECLIYG HSDACWMPAS LDHSSSSQAQ ASALCHSPPL SQASTQHHSP PVTQTIVLCH SPPVTQTIAL CHSPPPIQVS ALHHSPPLVQ GTALHHSPPS AQASALCYSP PLAQAAAISH SSSLPQVIAL HRSQAQSSVS LQQGWVQGAN GLCSVDQGVQ GSATSQFYTM SERLHPSDDS IKVIPLTTFA PRQQARPSRG DSPIMETHPL